{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:29:42Z","timestamp":1739510982070,"version":"3.37.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 82170595 and 81970070 to X-JZ"],"award-info":[{"award-number":["Grant No. 82170595 and 81970070 to X-JZ"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001857","name":"Sisters of Charity Foundation of South Carolina","doi-asserted-by":"publisher","award":["Grant No. GDXZ2022008 to XZ, GDXZ2022009 to WJ"],"award-info":[{"award-number":["Grant No. GDXZ2022008 to XZ, GDXZ2022009 to WJ"]}],"id":[{"id":"10.13039\/100001857","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Huazhong Agricultural University-Agricultural Genomics Institute at Shenzhen, Cooperation Fund","award":["No. SZYJY2022008 to ZQ"],"award-info":[{"award-number":["No. SZYJY2022008 to ZQ"]}]},{"name":"National special fund for research and development","award":["No. YFD051009 to M-XD"],"award-info":[{"award-number":["No. YFD051009 to M-XD"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec030\">\n<jats:title>\nObjective\n<\/jats:title>\n<jats:p>To investigate the role of quercetin-added pancreatic prescription food in regulating metabolic homeostasis in dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec031\">\n<jats:title>\nMethods\n<\/jats:title>\n<jats:p>The experimental dogs were divided into a control diet group and a prescription diet group. The control group was fed regular food, while the prescription group was fed pancreatic prescription food (3.9\u2009g of quercetin was added in per 1\u2009kg of food) for 8 weeks. Canine physical examination, complete blood count, and serum biochemical tests were conducted at 0 w, 4 w, and 8 w. Non-targeted metabolomics tests were performed using plasma samples at 0 w and 8 w.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec032\">\n<jats:title>\nResults\n<\/jats:title>\n<jats:p>Dogs that received a quercetin-added pancreatic diet supplemented with quercetin showed no changes in the body weight, fasting blood glucose, body condition score, the indexes of whole blood program of red blood cells, white blood cells and platelets, and most blood biochemical indexes, but increased lipase levels in plasma at 8 w. Quercetin significant improved in metabolic homeostasis, especially in fatty acid, amino acid, and bile acid metabolism. Untargeted metabolomics analysis revealed that quercetin activates ABC transport and arginine\/proline pathways, suggesting potential benefits for pancreatitis in large animals, while maintaining comparable safety parameters.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec033\">\n<jats:title>\nConclusions\n<\/jats:title>\n<jats:p>Quercetin-added prescription food enhances fatty acid and amino acid metabolism, demonstrating its potential to promote pancreatic function and sustain metabolic homeostasis.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0318159","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T18:48:22Z","timestamp":1739472502000},"page":"e0318159","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the effects of quercetin-added pancreatic diet on metabolic homeostasis in dogs via 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