{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:01:27Z","timestamp":1782230487794,"version":"3.54.5"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Qaff Africa Foundation"},{"name":"National Tuberculosis and Leprosy Programme"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Tuberculosis (TB) is still a major public health challenge globally and Uganda is one among the top 30 high TB burden countries. One of the key factors determining TB treatment success rates and thereby Cure Rates is the adherence to TB treatment, which is still a major challenge globally. WHO DOTS (Directly Observed Treatment Short course) strategy has several limitations and WHO End TB Strategy 2017 suggests a suite of new interventions to improve adherence.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objectives of the study<\/jats:title>\n<jats:p><jats:list list-type=\"simple\">\n<jats:list-item><jats:p>a. To present the development and design of ZMQ\u2019s Active Care and Treatment Strategy (ACTS) Model.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>b. To present the results of a pilot study done using the ACTS Model.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>c. To compare Treatment Adherence Rates between DOTS and Video Observed Treatment (VOT) in the four districts of Uganda.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>Includes presenting the ACTS Model, a pilot study to assess the AGB and ACF by way of a pre-post (Quasi-experimental) study (n = 1000) to assess the impact of AGB exercises, Focus Group Discussions (FGD) to get insights into factors contributing to treatment non-adherence and a comparison between VOT (n = 800) vs. DOTS for treatment adherence.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>There was a significant improvement (<jats:italic>p<\/jats:italic>&lt;0.01) in knowledge and awareness levels of community members post the AGB exercises which included creating awareness using digital storytelling, house visits and more. TB treatment adherence rates among TB patients using VOT was significantly better (<jats:italic>p<\/jats:italic>&lt;0.01) than those using DOTS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>AGB and ACF play a significant role in creating more awareness amongst the community members and identifying more number of cases. It helps in better treatment seeking behaviour, improved treatment rates and treatment adherence rates and in turn better cure rates. VOT is far more superior to DOTS, as a strategy for TB treatment adherence and VOT decreases the resources required in terms of human resource, time and money and is also a more sustainable mode of treatment adherence.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0318174","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:30:49Z","timestamp":1739903449000},"page":"e0318174","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["A community based, bottom-up, multi-pronged, technology integrated approach to enhance tuberculosis related awareness and treatment adherence in Uganda: The ACTS model"],"prefix":"10.1371","volume":"20","author":[{"given":"Stavia","family":"Turyahabwe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2392-5530","authenticated-orcid":true,"given":"Srikrishna Sulgodu","family":"Ramachandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhi","family":"Quraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilmana","family":"Fasih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmi","family":"Quraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palavardhan","family":"Peddapalegani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"issue":"9","key":"pone.0318174.ref001","doi-asserted-by":"crossref","first-page":"e0274112","DOI":"10.1371\/journal.pone.0274112","article-title":"Design, development and testing of a voice-text mobile health application to support Tuberculosis medication adherence in Uganda","volume":"17","author":"KK Katende","year":"2022","journal-title":"PLoS ONE"},{"key":"pone.0318174.ref002","unstructured":"World Health Organization, Geneva (2017). 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