{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:26:36Z","timestamp":1791822396879,"version":"4.3.4"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Development Plan of Jilin Province","award":["No. 20210204119YY"],"award-info":[{"award-number":["No. 20210204119YY"]}]},{"name":"Research Fund of Changzhou Medical Center","award":["NO. CZKY102RC202303"],"award-info":[{"award-number":["NO. CZKY102RC202303"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec018\">\n<jats:title>Background<\/jats:title>\n<jats:p>The aim of this study is to examine the critical variables that impact the long-term prognosis of patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) and to create a multidimensional predictive risk assessment model that can serve as a theoretical basis for accurate cardiac rehabilitation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec019\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The study involved ACS patients who received PCI at the First Hospital of Jilin University from June 2020 to March 2021. Participants were categorized into two groups: acute myocardial infarction (AMI) and unstable angina (UA), according to clinical data and angiographic findings. Hospitalization data, physical performance, exercise tolerance prior to discharge, average daily steps, major adverse cardiac events (MACE), and a follow-up period of 36 months were documented. The dates for accessing data for research purposes are February 10, 2022 (10\/2\/2022) to December 10, 2023 (10\/12\/2023).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec020\">\n<jats:title>Results<\/jats:title>\n<jats:p>We observed substantial increases in weight, fasting plasma glucose (FPG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), white blood cell (WBC) count, neutrophil granulocyte count, monocyte count, hemoglobin (Hb) levels, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels in the acute myocardial infarction (AMI) cohort relative to the unstable angina (UA) cohort. We found white blood cell count (WBC) (OR: 4.110) and the effective average number of daily steps (ANS) (OR: 2.689) as independent prognostic risk factors for acute myocardial infarction (AMI). The independent risk factors for unstable angina prognosis were white blood cell count (OR: 6.257), VO2 at anaerobic threshold (OR: 4.294), and effective autonomic nervous system function (OR: 4.097). The whole prognostic risk assessment score for acute myocardial infarction (AMI) is 5 points, with 0 points signifying low risk, 2\u20133 points representing intermediate risk, and 5 points indicating high risk. The overall prognostic risk assessment score for UA is 7 points, with 0\u20133 classified as low risk, 4\u20135 as intermediate risk, and 6\u20137 as high risk.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec021\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study developed a multimodal predictive model that integrates the inflammatory response after onset, physical performance and exercise tolerance before discharge, and daily activity after discharge to predict the long-term prognosis of patients with ACS. The multidimensional model is more effective than the single-factor model for assessing risk in ACS patients. This work also establishes a theoretical basis for improving the prognosis of potentially high-risk individuals with accurate and reasonable exercise prescriptions.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0318445","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T17:41:14Z","timestamp":1746639674000},"page":"e0318445","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of a multidimensional prediction model for long-term prognostic risk in patients with acute coronary syndromes after percutaneous coronary intervention: A retrospective observational cohort study"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3935-3448","authenticated-orcid":true,"given":"Bojian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-5159","authenticated-orcid":true,"given":"Pengyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangshu","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"issue":"5","key":"pone.0318445.ref001","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1056\/NEJMra1607714","article-title":"Management of Antithrombotic Therapy after Acute Coronary Syndromes","volume":"384","author":"F Rodriguez","year":"2021","journal-title":"N Engl J Med"},{"issue":"22","key":"pone.0318445.ref002","first-page":"e368","article-title":"2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"144","author":"M Gulati","year":"2021","journal-title":"Circulation"},{"key":"pone.0318445.ref003","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.jacc.2018.06.033","article-title":"Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease","volume":"72","author":"CM Cook","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"pone.0318445.ref004","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1161\/CIRCULATIONAHA.117.030798","article-title":"Acute Myocardial Infarction: Changes in Patient Characteristics, Management, and 6-Month Outcomes Over a Period of 20 Years in the FAST-MI Program (French Registry of Acute ST-Elevation or Non-ST-Elevation Myocardial Infarction) 1995 to 2015","volume":"136","author":"E Puymirat","year":"2017","journal-title":"Circulation"},{"issue":"22","key":"pone.0318445.ref005","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1093\/eurheartj\/ehq326","article-title":"Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK-Belgian Study)","volume":"31","author":"KAA Fox","year":"2010","journal-title":"Eur Heart J"},{"issue":"6","key":"pone.0318445.ref006","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/medicina57060529","article-title":"Cardiac Rehabilitation and Complementary Physical Training in Elderly Patients after Acute Coronary Syndrome: A Pilot Study","volume":"57","author":"A Beigien\u0117","year":"2021","journal-title":"Medicina (Kaunas)"},{"issue":"21","key":"pone.0318445.ref007","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1136\/heartjnl-2019-316349","article-title":"Exercise intervention improves quality of life in older adults after myocardial infarction: randomised clinical trial","volume":"106","author":"G Campo","year":"2020","journal-title":"Heart"},{"issue":"8","key":"pone.0318445.ref008","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.jamda.2020.09.038","article-title":"The Short Physical Performance Battery (SPPB): A Quick and Useful Tool for Fall Risk Stratification Among Older Primary Care Patients","volume":"22","author":"SA Welch","year":"2021","journal-title":"J Am Med Dir Assoc"},{"issue":"23","key":"pone.0318445.ref009","doi-asserted-by":"crossref","first-page":"16319","DOI":"10.3390\/ijerph192316319","article-title":"Associations of the Short Physical Performance Battery (SPPB) with Adverse Health Outcomes in Older Adults: A 14-Year Follow-Up from the English Longitudinal Study of Ageing (ELSA)","volume":"19","author":"MJ Western","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"pone.0318445.ref010","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2217\/fca.10.21","article-title":"The future of aerobic exercise testing in clinical practice: is it the ultimate vital sign?","volume":"6","author":"R Arena","year":"2010","journal-title":"Future Cardiol"},{"issue":"5","key":"pone.0318445.ref011","first-page":"432","article-title":"Chinese expert consensus on standardized clinical application of 6-minute walk test","volume":"50","author":"Chinese Society of Cardiology, Chinese Medical Association, Professional Committee of Cardiopulmonary Prevention and Rehabilitation of Chinese Rehabilitation Medical Association, Editorial Board of Chinese Journal of Cardiology","year":"2022","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"issue":"10","key":"pone.0318445.ref012","first-page":"973","article-title":"Chinese expert consensus on standardized clinical application of cardiopulmonary exercise testing","volume":"50","author":"Chinese Society of Cardiology, Chinese Medical Association, Professional Committee of Cardiopulmonary Prevention and Rehabilitation of Chinese Rehabilitation Medical Association, Editorial Board of Chinese Journal of Cardiology","year":"2022","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"issue":"1","key":"pone.0318445.ref013","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12872-019-1189-x","article-title":"Effect of pre-discharge cardiopulmonary fitness on outcomes in patients with ST-elevation myocardial infarction after percutaneous coronary intervention","volume":"19","author":"H Cai","year":"2019","journal-title":"BMC Cardiovasc Disord"},{"key":"pone.0318445.ref014","doi-asserted-by":"crossref","first-page":"1126413","DOI":"10.3389\/fpubh.2023.1126413","article-title":"Daily exercise improves the long-term prognosis of patients with acute coronary syndrome","volume":"11","author":"Q Hu","year":"2023","journal-title":"Front Public Health"},{"issue":"11","key":"pone.0318445.ref015","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1001\/jamainternmed.2022.4000","article-title":"Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality","volume":"182","author":"B Del Pozo Cruz","year":"2022","journal-title":"JAMA Intern Med"},{"issue":"3","key":"pone.0318445.ref016","doi-asserted-by":"crossref","first-page":"e235174","DOI":"10.1001\/jamanetworkopen.2023.5174","article-title":"Association of Daily Step Patterns with Mortality in US Adults","volume":"6","author":"K Inoue","year":"2023","journal-title":"JAMA Netw Open"},{"key":"pone.0318445.ref017","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.jacc.2023.07.029","article-title":"Relationship of Daily Step Counts to All-Cause Mortality and Cardiovascular Events","volume":"82","author":"NA Stens","year":"2023","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"pone.0318445.ref018","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12933-020-01054-z","article-title":"Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome","volume":"19","author":"L Wang","year":"2020","journal-title":"Cardiovasc Diabetol"},{"issue":"7","key":"pone.0318445.ref019","doi-asserted-by":"crossref","first-page":"666","DOI":"10.5603\/KP.a2017.0068","article-title":"The prognostic value of the platelet-to-lymphocyte ratio in acute coronary syndrome: a systematic review and meta-analysis","volume":"75","author":"H Li","year":"2017","journal-title":"Kardiol Pol"},{"issue":"8","key":"pone.0318445.ref020","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1177\/2048872617719638","article-title":"Predicting two-year mortality from discharge after acute coronary syndrome: An internationally-based risk score","volume":"8","author":"SJ Pocock","year":"2019","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"pone.0318445.ref021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2018.09.080","article-title":"Factors associated with objectively measured exercise participation after hospitalization for acute coronary syndrome","volume":"275","author":"AM Goodwin","year":"2019","journal-title":"Int J Cardiol"},{"issue":"1","key":"pone.0318445.ref022","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12872-016-0356-6","article-title":"SMARTphone-based, early cardiac REHABilitation in patients with acute coronary syndromes [SMART-REHAB Trial]: a randomized controlled trial protocol","volume":"16","author":"MB Yudi","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"pone.0318445.ref023","volume-title":"Registry. C-CCT: impact of environmental factors on the incidence of acute myocardial infarction. ChiCTR-ID: ChiCTR2100053140"},{"issue":"14","key":"pone.0318445.ref024","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"J-P Collet","year":"2021","journal-title":"Eur Heart J"},{"issue":"1","key":"pone.0318445.ref025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS statement: guidelines for the six-minute walk test","volume":"166","author":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"pone.0318445.ref026","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/eurheartj\/ehy462","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"40","author":"K Thygesen","year":"2019","journal-title":"Eur Heart J"},{"issue":"38","key":"pone.0318445.ref027","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"RA Byrne","year":"2023","journal-title":"Eur Heart J"},{"issue":"10","key":"pone.0318445.ref028","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jacc.2004.07.056","article-title":"Leukocyte count and coronary heart disease: implications for risk assessment","volume":"44","author":"M Madjid","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"pone.0318445.ref029","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/s-0035-1544178","article-title":"Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction","volume":"24","author":"S Dharma","year":"2015","journal-title":"Int J Angiol"},{"issue":"1","key":"pone.0318445.ref030","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12933-023-01904-6","article-title":"Impact of the SGLT2-inhibitor empagliflozin on inflammatory biomarkers after acute myocardial infarction - a post-hoc analysis of the EMMY trial","volume":"22","author":"M Benedikt","year":"2023","journal-title":"Cardiovasc Diabetol"},{"issue":"2","key":"pone.0318445.ref031","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ijcard.2014.09.002","article-title":"Serum transaminase determined in the emergency room predicts outcomes in patients with acute ST-segment elevation myocardial infarction who undergo primary percutaneous coronary intervention","volume":"177","author":"J Moon","year":"2014","journal-title":"Int J Cardiol"},{"issue":"1","key":"pone.0318445.ref032","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3390\/jcm12010310","article-title":"Markedly Elevated Aspartate Aminotransferase from Non-Hepatic Causes","volume":"12","author":"J-H Han","year":"2022","journal-title":"J Clin Med"},{"issue":"9","key":"pone.0318445.ref033","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/ehjacc\/zuad059","article-title":"Sex- and age-related differences in outcomes of patients with acute myocardial infarction: MINOCA vs. MIOCA","volume":"12","author":"L Canton","year":"2023","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"pone.0318445.ref034","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fcvm.2020.00130","article-title":"Prediction Factors of 6-Month Poor Prognosis in Acute Myocardial Infarction Patients","volume":"7","author":"J Yao","year":"2020","journal-title":"Front Cardiovasc Med"},{"issue":"8","key":"pone.0318445.ref035","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1177\/2047487319826398","article-title":"Predictive value of in-hospital white blood cell count in Chinese patients with triple-vessel coronary disease","volume":"26","author":"X Zhao","year":"2019","journal-title":"Eur J Prev Cardiol"},{"issue":"12","key":"pone.0318445.ref036","first-page":"2090","article-title":"Long-Term Predictors of Hospitalized Reinfarction after an Incident Acute Myocardial Infarction","volume":"12","author":"T Schmitz","year":"2022","journal-title":"Life (Basel)"},{"issue":"3","key":"pone.0318445.ref037","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/2048872614528858","article-title":"Prognostic impact of admission blood glucose for all-cause mortality in patients with acute coronary syndromes: added value on top of GRACE risk score","volume":"3","author":"AT Tim\u00f3teo","year":"2014","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"4","key":"pone.0318445.ref038","doi-asserted-by":"crossref","first-page":"e181079","DOI":"10.1001\/jamanetworkopen.2018.1079","article-title":"Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction","volume":"1","author":"Y Wang","year":"2018","journal-title":"JAMA Netw Open"},{"issue":"1125","key":"pone.0318445.ref039","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/postgradmedj-2018-136334","article-title":"Evaluation of acute myocardial infarction patients with mid-range ejection fraction after emergency percutaneous coronary intervention","volume":"95","author":"Y Jiang","year":"2019","journal-title":"Postgrad Med J"},{"issue":"8","key":"pone.0318445.ref040","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1080\/00015385.2021.1963564","article-title":"Neutrophil-to-lymphocyte ratio predicts coronary artery lesion severity and long-term cardiovascular mortality in patients with unstable angina pectoris","volume":"77","author":"S Li","year":"2022","journal-title":"Acta Cardiol"},{"key":"pone.0318445.ref041","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.ijcard.2016.11.148","article-title":"Clinical characteristics and prognosis of acute coronary syndrome in young women and men: A systematic review and meta-analysis of prospective studies","volume":"228","author":"Q Ma","year":"2017","journal-title":"Int J Cardiol"},{"issue":"10","key":"pone.0318445.ref042","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s10554-021-02252-w","article-title":"Relationship among clinical characteristics, morphological culprit plaque features, and long-term prognosis in patients with acute coronary syndrome","volume":"37","author":"A Nagasawa","year":"2021","journal-title":"Int J Cardiovasc Imaging"},{"issue":"1","key":"pone.0318445.ref043","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12933-019-0946-6","article-title":"Diabetes and baseline glucose are associated with inflammation, left ventricular function and short- and long-term outcome in acute coronary syndromes: role of the novel biomarker Cyr 61","volume":"18","author":"P Winzap","year":"2019","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"pone.0318445.ref044","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ehf2.14201","article-title":"Long-term mortality after acute coronary syndromes among patients with normal, mildly reduced, or reduced ejection fraction","volume":"10","author":"RHM Furtado","year":"2023","journal-title":"ESC Heart Fail"},{"issue":"23","key":"pone.0318445.ref045","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.jacc.2009.09.009","article-title":"Inflammation in atherosclerosis: from pathophysiology to practice","volume":"54","author":"Leducq Transatlantic Network on Atherothrombosis","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"pone.0318445.ref046","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pharmthera.2018.01.001","article-title":"Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities","volume":"186","author":"S-B Ong","year":"2018","journal-title":"Pharmacol Ther"},{"issue":"2","key":"pone.0318445.ref047","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/1076029614531449","article-title":"White blood cell counts, leukocyte ratios, and eosinophils as inflammatory markers in patients with coronary artery disease","volume":"21","author":"NG Kounis","year":"2015","journal-title":"Clin Appl Thromb Hemost"},{"issue":"5","key":"pone.0318445.ref048","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/01.STR.0000124122.71702.64","article-title":"Leukocyte count as an independent predictor of recurrent ischemic events","volume":"35","author":"AJ Grau","year":"2004","journal-title":"Stroke"},{"issue":"10","key":"pone.0318445.ref049","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/heart.89.10.1200","article-title":"Impact of preprocedural white blood cell count on long term mortality after percutaneous coronary intervention: insights from the EPIC, EPILOG, and EPISTENT trials","volume":"89","author":"HS Gurm","year":"2003","journal-title":"Heart"},{"key":"pone.0318445.ref050","first-page":"775","article-title":"The baseline leucocyte count is a strong and independent predictor of mortality in patients undergoing Percutaneous Coronary artery Interventions Implications of arterial inflammation","volume":"104","author":"HS Gurm","year":"2001","journal-title":"Circulation"},{"issue":"24","key":"pone.0318445.ref051","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1161\/CIR.0000000000000461","article-title":"Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign: A Scientific Statement From the American Heart Association","volume":"134","author":"R Ross","year":"2016","journal-title":"Circulation"},{"issue":"6","key":"pone.0318445.ref052","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCHEARTFAILURE.109.881326","article-title":"Six-minute walk test and cardiopulmonary exercise testing in patients with chronic heart failure: a comparative analysis on clinical and prognostic insights","volume":"2","author":"M Guazzi","year":"2009","journal-title":"Circ Heart Fail"},{"issue":"8","key":"pone.0318445.ref053","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.21037\/jtd-23-554","article-title":"Development of a prediction model for exercise tolerance decline in the exercise assessment of patients with acute myocardial infarction undergoing percutaneous coronary intervention revascularization in the acute phase","volume":"15","author":"M Du","year":"2023","journal-title":"J Thorac Dis"},{"key":"pone.0318445.ref054","doi-asserted-by":"crossref","first-page":"798446","DOI":"10.3389\/fcvm.2022.798446","article-title":"Development and Validation of a Prediction Model for Cardiovascular Events in Exercise Assessment of Coronary Heart Disease Patients After Percutaneous Coronary Intervention","volume":"9","author":"T Shen","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"pone.0318445.ref055","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1590\/1414-431x20144235","article-title":"Intensity and physiological responses to the 6-minute walk test in middle-aged and older adults: a comparison with cardiopulmonary exercise testing","volume":"48","author":"EF Sperandio","year":"2015","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"pone.0318445.ref056","doi-asserted-by":"crossref","first-page":"20458940211059055","DOI":"10.1177\/20458940211059055","article-title":"The association of six-minute walk work and other clinical measures to cardiopulmonary exercise test parameters in pulmonary vascular disease","volume":"11","author":"L C Robertson","year":"2021","journal-title":"Pulm Circ"},{"issue":"1","key":"pone.0318445.ref057","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.amjcard.2005.07.129","article-title":"Cardiopulmonary exercise testing and six-minute walk correlations in pulmonary arterial hypertension","volume":"97","author":"RJ Oudiz","year":"2006","journal-title":"Am J Cardiol"},{"issue":"2","key":"pone.0318445.ref058","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1253\/circj.72.299","article-title":"Target step count for the secondary prevention of cardiovascular disease","volume":"72","author":"M Ayabe","year":"2008","journal-title":"Circ J"},{"issue":"8","key":"pone.0318445.ref059","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1007\/s00380-020-01576-2","article-title":"Reduced exercise capacity and clinical outcomes following acute myocardial infarction","volume":"35","author":"H Tashiro","year":"2020","journal-title":"Heart Vessels"},{"issue":"41","key":"pone.0318445.ref060","doi-asserted-by":"crossref","first-page":"e35636","DOI":"10.1097\/MD.0000000000035636","article-title":"The relationship of the hemoglobin to serum creatinine ratio with long-term mortality in patients with acute coronary syndrome: A retrospective study","volume":"102","author":"M Demir","year":"2023","journal-title":"Medicine (Baltimore)"},{"issue":"Supplement_1","key":"pone.0318445.ref061","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehae666.1571","article-title":"Hemoglobin\/creatinine ratio as long- term prognostic marker in acute coronary syndromes: a praise registry study","volume":"45","author":"L Spadafora","year":"2024","journal-title":"European Heart Journal"},{"key":"pone.0318445.ref062","doi-asserted-by":"crossref","first-page":"132663","DOI":"10.1016\/j.ijcard.2024.132663","article-title":"Triglyceride-glucose index (TyG) as a novel biomarker in the era of cardiometabolic medicine","volume":"418","author":"A Avagimyan","year":"2025","journal-title":"Int J Cardiol"},{"issue":"4","key":"pone.0318445.ref063","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1001\/jamaneurol.2023.0044","article-title":"Stepping Closer to Precision Rehabilitation","volume":"80","author":"DJ Lin","year":"2023","journal-title":"JAMA Neurol"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0318445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T17:41:31Z","timestamp":1746639691000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0318445"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"And\u00f2","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":63,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0318445","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,7]]}}}