{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:17:53Z","timestamp":1783372673732,"version":"3.54.6"},"reference-count":101,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec026\">\n<jats:title>Background<\/jats:title>\n<jats:p>Insecure adult attachment has previously been linked to more severe psychopathology and to alterations within neuronal connectivity on a structural as well as functional level. Little is known about the resting state functional connectivity (rs-FC) of the attachment system in patients suffering from poly-drug use disorder (PUD).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec027\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The present study investigated rs-FC at two measuring points (t1: ROI-to-ROI; t2: seed-to-voxel) in a sample of PUD patients (n = 33; Age: M = 30y; SD = 8y; Female = 15%). Adult attachment was measured with the German version of the Experiences in Close Relationships Scale (ECR-RD8). Furthermore, insecure attachment was correlated with depressive symptoms (ADS), trait anxiety (STAI) and general psychopathology (BSI-53).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec028\">\n<jats:title>Results<\/jats:title>\n<jats:p>More insecure attachment was associated with increased trait anxiety, depressive and general psychiatric symptom burden in patients. Furthermore, we observed time-stable links between insecure adult attachment and increased rs-FC between the left lateral parietal default mode network (DMN LP) and bilateral parts of the salience network, as well as decreased rs-FC between DMN LP and medial parts of the DMN.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec029\">\n<jats:title>Discussion<\/jats:title>\n<jats:p>Implications of the present study are highlighting the association between attachment security and brain areas related to affect regulation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0318505","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T18:41:01Z","timestamp":1739385661000},"page":"e0318505","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of insecure attachment on fMRI resting state functional connectivity in poly drug use disorder"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2932-9029","authenticated-orcid":true,"given":"J\u00fcrgen","family":"Fuchshuber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-0498","authenticated-orcid":true,"given":"Karl","family":"Koschutnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Alexopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8785-0435","authenticated-orcid":true,"given":"Henriette","family":"L\u00f6ffler-Stastka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-0214","authenticated-orcid":true,"given":"Human-Friedrich","family":"Unterrainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"pone.0318505.ref001","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3389\/fpsyt.2019.00727","article-title":"Attachment 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