{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T05:29:36Z","timestamp":1740115776933,"version":"3.37.3"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Call for Research Projects \u2013 Psychoactive Substances and Addictive Behaviours","award":["SPAV1-23-001-2023-201"],"award-info":[{"award-number":["SPAV1-23-001-2023-201"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Tobacco use is one of the leading causes of preventable disease and death worldwide. Despite the availability of evidence-based pharmacological treatments, only a small number of individuals with tobacco use disorder achieve long-term abstinence after smoking cessation. This highlights the need to enhance existing interventions. In this protocol, we describe our single-center mixed-method trial, HowToMind, conducted in Dijon, France. This trial aims to investigate the usability and acceptability of a digital mindfulness-based intervention designed to complement standard smoking cessation treatment to potentiate its effects.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We will include 60 adults seeking treatment for tobacco use disorder, as defined by DSM-5 criteria, who wish to quit smoking and own a smartphone. All participants will receive a combination of transdermal and oral nicotine replacement therapy and will be introduced to an eHealth app that provides a digital equivalent of an 8-week mindfulness training program. The acceptability of the initial version of our app will be assessed based on usage frequency, and usability will be evaluated using the Mobile App Rating Scale (French version). A participatory approach will be employed through focus groups conducted at the end of the 8 weeks of app use, aimed at co-constructing the final version of the app based on participant feedback.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Discussion<\/jats:title>\n<jats:p>Our pilot mixed-method trial seeks to explore the usability and acceptability of our app, making necessary adjustments to its content and functionality based on participant feedback before its implementation in a large randomized controlled trial assessing the app\u2019s potential to enhance the effects of standard treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>ClinicalTrials.gov, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT06500117\" xlink:type=\"simple\">NCT06500117<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0318686","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T18:26:16Z","timestamp":1740075976000},"page":"e0318686","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Usability of a digital mindfulness training program for smoking cessation: A mixed-method single-center pilot study protocol (HowToMind)"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-6618","authenticated-orcid":true,"given":"Anastasia","family":"Demina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Soudry-Faure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6670-7920","authenticated-orcid":true,"given":"Benjamin","family":"Petit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Meunier-Beillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Trojak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"pone.0318686.ref001","unstructured":"National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. 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