{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T05:19:44Z","timestamp":1739596784269,"version":"3.37.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Cherubism is a rare genetic disorder caused by <jats:italic>SH3BP2<\/jats:italic> mutations. This sterile autoinflammatory disease is characterized by jaw osteolysis, in which bone tissue is replaced by multinucleated giant cells containing fibrous tissue. The cherubism mouse model (<jats:italic>Sh3bp2<\/jats:italic> KI) is characterized by systemic bone loss as well as inflammatory phenotypes induced and maintained by TNF\u03b1. IL-1\u03b2, produced by the NRLP3 inflammasome through recruitment of Caspase-1, is involved in the development of sterile autoinflammatory disease. We previously reported a cherubism patient with elevated serum IL-1\u03b2, and cherubism mice also have elevated serum IL-1\u03b2 levels. Thus, we wanted to disentangle the role of IL-1\u03b2 in cherubism. To that end, we deleted <jats:italic>Caspase-1<\/jats:italic> in <jats:italic>Sh3bp2<\/jats:italic> KI mice to tamp down IL-1\u03b2 production. However, deleting <jats:italic>Caspase-1<\/jats:italic> did not rescue the systemic bone and inflammatory phenotypes.<\/jats:p>","DOI":"10.1371\/journal.pone.0318826","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T18:37:41Z","timestamp":1739558261000},"page":"e0318826","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The bone phenotype associated with cherubism is independent of Caspase-1-dependent inflammasome activation in the mouse"],"prefix":"10.1371","volume":"20","author":[{"given":"Badre-Victor","family":"Rabhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Thomasseau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Decrouy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Cohen-Solal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Deckert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie 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