{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:45:51Z","timestamp":1783464351661,"version":"3.55.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\nBackground<\/jats:title>\nVenous thromboembolism (VTE) is a significant and avoidable complication that may occur after total hip arthroplasty (THA). Various mechanical and chemical prophylactic measures may mitigate this elevated risk of death and functional impairment. Consequently, early prevention of VTE is essential via the identification of related risk factors.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nA search was performed using the databases of PubMed, ScienceDirect, PEDro, and Cochrane Library to get papers from 2004 to 2024 in accordance with PRISMA guidelines. Only randomized controlled trials (RCTs) published in English that included at least one group undergoing intermittent pneumatic compression (IPC) treatment as a prophylactic intervention after total hip arthroplasty (THA) were included. This systematic review has been registered in PROSPERO. The quality evaluation of the included studies was conducted using the PEDro scale and the Cochrane risk of bias instrument.<\/jats:p>\n<\/jats:sec>\n\nResult<\/jats:title>\nWe selected 12 studies from a total of 733 based on predetermined criteria. A total of 2,352 patients of both genders underwent total hip arthroplasty, comprising 1,294 patients in the experimental group and 1,058 patients in the control group across the included studies. The results indicate that the combination of IPC and pharmaceutical agents was the most effective treatment for reducing VTE risk in patients who underwent THA.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nIPC therapy is very effective in avoiding VTE, particularly when used in combination with pharmacological therapies after THA surgery. The best ways to lower the risk of VTE are to use both IPC and anticoagulants together. However, IPC alone may lower the risk of VTE compared to not using any prevention at all. In general, IPC is a crucial component of comprehensive VTE prevention strategies in THA.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0318954","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T17:42:09Z","timestamp":1749058929000},"page":"e0318954","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intermittent pneumatic compression therapy as a preventive measure for venous thromboembolism after total hip arthroplasty: A systematic review"],"prefix":"10.1371","volume":"20","author":[{"given":"Vishal","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arushi","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeksha","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umang","family":"Singal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najeeb","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-1855","authenticated-orcid":true,"given":"Mohammad Jahirul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Amran","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Saifur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-9841","authenticated-orcid":true,"given":"Sohel","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"issue":"4","key":"pone.0318954.ref001","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3889\/oamjms.2019.088","article-title":"Templating Hip Arthroplasty","volume":"7","author":"A Alnahhal","year":"2019","journal-title":"Open Access Maced J Med Sci"},{"issue":"9","key":"pone.0318954.ref002","first-page":"455","article-title":"Total hip arthroplasty: techniques and results","volume":"52","author":"RS Burnett","year":"2010","journal-title":"BC Med J"},{"issue":"1","key":"pone.0318954.ref003","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13018-023-04443-8","article-title":"Incidence and risk factors of perioperative deep vein thrombosis in patients undergoing primary hip arthroplasty via the direct anterior approach","volume":"19","author":"Z Zhuang","year":"2024","journal-title":"J Orthop Surg Res"},{"issue":"2","key":"pone.0318954.ref004","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11999-015-4341-7","article-title":"Complications of Total Hip Arthroplasty: Standardized List, Definitions, and Stratification Developed by The Hip Society","volume":"474","author":"WL Healy","year":"2016","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"pone.0318954.ref005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5371\/hp.2014.26.4.207","article-title":"Experience of Complications of Hip Arthroplasty","volume":"26","author":"SK Hwang","year":"2014","journal-title":"Hip Pelvis"},{"issue":"12","key":"pone.0318954.ref006","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.3390\/jcm12124164","article-title":"Pneumatic Compression Combined with Standard Treatment after Total Hip Arthroplasty and Its Effects on Edema of the Operated Limb and on Physical Outcomes: A Pilot Clinical Randomized Controlled Study","volume":"12","author":"V Carnevale Pellino","year":"2023","journal-title":"J Clin Med"},{"issue":"1","key":"pone.0318954.ref007","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4055\/cios.2017.9.1.37","article-title":"Intermittent Pneumatic Compression for the Prevention of Venous Thromboembolism after Total Hip Arthroplasty","volume":"9","author":"HS Kwak","year":"2017","journal-title":"Clin Orthop Surg"},{"key":"pone.0318954.ref008","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12891-015-0470-0","article-title":"Risk factors for venous thromboembolism of total hip arthroplasty and total knee arthroplasty: a systematic review of evidences in ten years","volume":"16","author":"Z Zhang","year":"2015","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"pone.0318954.ref009","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.artd.2018.02.014","article-title":"What are the incidence and risk factors of in-hospital mortality after venous thromboembolism events in total hip and knee arthroplasty patients?","volume":"4","author":"A Shahi","year":"2018","journal-title":"Arthroplast Today"},{"key":"pone.0318954.ref010","first-page":"109","article-title":"Efficacy and safety of Aspirin plus intermittent pneumatic compression device as thromboprophylaxis after total hip arthroplasty: prospective randomized control trial","volume":"85","author":"S Paudel","year":"2019","journal-title":"Acta Orthop Belg"},{"issue":"8","key":"pone.0318954.ref011","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.3346\/jkms.2016.31.8.1319","article-title":"Preventing Venous Thromboembolism with Use of Intermittent Pneumatic Compression after Total Hip Arthroplasty in Korean Patients","volume":"31","author":"W-L Jo","year":"2016","journal-title":"J Korean Med Sci"},{"issue":"3","key":"pone.0318954.ref012","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/03091900601015147","article-title":"Intermittent pneumatic compression - 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