{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:01:22Z","timestamp":1773158482400,"version":"3.50.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Henan Province medical science and technology research plan joint construction project","award":["LHGJ20210315"],"award-info":[{"award-number":["LHGJ20210315"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>\nObjective\n<\/jats:title>\n<jats:p>To investigate the epidemiological trends,etiological profiles and disease burden metrics related to postoperative pneumonia following isolated coronary artery bypass grafting (CABG).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>\nMethods\n<\/jats:title>\n<jats:p>A retrospective analysis was conducted on data from 518 patients who developed postoperative pneumonia following isolated CABG between January 1, 2020, and November 30, 2023.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>\nResults\n<\/jats:title>\n<jats:p>Postoperative pneumonia occurred at a rate of 11.34% among the cohort (518\/4569),which fluctuated by year (P\u2009&lt;\u20090.001). Patients aged 60\u201380 and over 80 years exhibited significantly higher incidence rates compared to those under 60 years (all P &lt; 0.05) A total of 416 strains were identified, with Gram-negative bacteria accounting for 86.5%, primarily represented by <jats:italic>Klebsiella pneumoniae<\/jats:italic> (31.0%), while <jats:italic>pseudomonas aeruginosa<\/jats:italic> (21.4%) and <jats:italic>stenotrophomonas maltophilia<\/jats:italic> (5.3%) demonstrated an increasing trend in the period of 2022\u20132023 (both P\u2009&lt;\u20090.05). The proportion of <jats:italic>Staphylococcus aureus<\/jats:italic> in the fourth quarter was significant lower than that in the first quarter (4.8% vs 14.4%, P\u2009&lt;\u20090.05). The overall detection rate of multi-drug resistant organisms (MDRO) was 57.7%,with 53.9% for Gram-negative bacteria and 82.1% for Gram-positive bacteria.Late-onset postoperative pneumonia was significantly associated with a higher detection rate of MDRO (63.8% vs 50.3%, P &lt; 0.01). Postoperative pneumonia prolonged median length of postoperative hospital[20.00 (13.00,31.25) days vs 15.50(10.25,19.75) days, P\u2009&lt;\u20090.001] and ICU [9.00(5.00,14.00)days vs 4.00(3.00,11.75) days, P\u2009=\u20090.002] stay, thereby increasing hospitalization costs[\uffe5255592.15 (193384.29, 336337.53) vs \uffe5180501.02 (154493.58, 220501.03),P &lt; 0.001]. The incidence of severe pneumonia significantly increased in patients infected with MDRO (19.30% vs. 5.51%, P &lt; 0.001) or co-infected (40.00% vs. 9.52%, P &lt; 0.001), leading to marked differences in postoperative hospital stay and hospitalization costs (all P &lt; 0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>\nConclusion\n<\/jats:title>\n<jats:p>The etiological patterns of postoperative pneumonia following isolated CABG showed temporal variations by year and quarter. MDRO infection and co-infections could significantly exacerbate the disease burden on patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0319017","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:36:13Z","timestamp":1741714573000},"page":"e0319017","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Postoperative pneumonia in isolated coronary artery bypass grafting: A comprehensive study of epidemiology, etiology, and disease burden from China 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