{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T05:32:38Z","timestamp":1740547958303,"version":"3.38.0"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["20210060159"],"award-info":[{"award-number":["20210060159"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["20220060087"],"award-info":[{"award-number":["20220060087"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec041\">\n<jats:title>Background<\/jats:title>\n<jats:p>Traumatic cerebral contusion (CC) is a severe type of injury among traumatic brain injury (TBI) patients. Individuals with traumatic CC typically exhibit rapid deterioration in their condition, leading to increased mortality rates. Despite this, there is a gap in evidence-based research. This study aims to identify the risk factors associated with adverse outcomes in patients with traumatic CC, with a particular focus on relevant biomarkers. Mortality will be the primary outcome, while the Glasgow Coma Scale (GCS) score will be considered as a secondary outcome.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec042\">\n<jats:title>Methods and analysis<\/jats:title>\n<jats:p>We intend to conduct a comprehensive search through multiple Chinese and English repositories, covering the duration from the establishment of these databases up to the current era, in order to pinpoint appropriate studies. Additionally, a manual search of the references within the included literature and other pertinent works will be undertaken. The primary endpoint of this study will be the survival status of patients with traumatic brain contusion. Meta-analysis will be executed using STATA 16.0 (Stata Corporation, College Station, TX). Article selection and data extraction will be performed independently by two reviewers. The assessment of bias risks will be conducted via the Cochrane Collaboration\u2019s tool. Depending on the heterogeneity evaluation, either a fixed-effect model or a random-effects model will be applied. Subgroup and sensitivity analyses will be conducted as needed. The examination of publication bias will be carried out, and the quality of evidence for the primary outcomes will be graded.<\/jats:p>\n<jats:p><jats:bold>Trial registration number:<\/jats:bold> CRD42023389456<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0319146","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T18:32:37Z","timestamp":1740508357000},"page":"e0319146","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors affecting prognosis in traumatic cerebral contusions: A protocol for a systematic review and meta-analysis"],"prefix":"10.1371","volume":"20","author":[{"given":"Chao","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyin","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1981-3603","authenticated-orcid":true,"given":"Kun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"issue":"3","key":"pone.0319146.ref001","first-page":"508","article-title":"Early progression of traumatic cerebral contusions: characterization and risk factors","volume":"67","author":"CL White","year":"2009","journal-title":"J Trauma"},{"issue":"7","key":"pone.0319146.ref002","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1007\/s10072-022-05954-8","article-title":"Initial ct-based radiomics nomogram for predicting in-hospital mortality in patients with traumatic brain injury: a multicenter development and validation study","volume":"43","author":"RZ Zheng","year":"2022","journal-title":"Neurol Sci"},{"issue":"8","key":"pone.0319146.ref003","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S1474-4422(20)30182-4","article-title":"Clinical characteristics and outcomes in patients with traumatic brain injury in china: a prospective, multicentre, longitudinal, observational study","volume":"19","author":"China CENTER-TBI Registry Participants","year":"2020","journal-title":"Lancet Neurol"},{"key":"pone.0319146.ref004","first-page":"11","article-title":"Chinese admission warning strategy for predicting the hospital discharge outcome in patients with traumatic brain injury","author":"R Zheng","year":"2022","journal-title":"J Clin Med"},{"issue":"4","key":"pone.0319146.ref005","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1474-4422(12)70038-8","article-title":"Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the ct-angiography spot sign (predict): a prospective observational study","volume":"11","author":"PREDICT\/Sunnybrook ICH CTA study group","year":"2012","journal-title":"Lancet Neurol"},{"issue":"8","key":"pone.0319146.ref006","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S1474-4422(17)30197-7","article-title":"Coagulopathy and haemorrhagic progression in traumatic brain injury: advances in mechanisms, diagnosis, and management","volume":"16","author":"M Maegele","year":"2017","journal-title":"Lancet Neurol"},{"key":"pone.0319146.ref007","doi-asserted-by":"crossref","first-page":"e470","DOI":"10.1016\/j.wneu.2020.02.004","article-title":"Nomogram model for predicting hematoma expansion in spontaneous intracerebral hemorrhage: multicenter retrospective study","volume":"137","author":"M Yang","year":"2020","journal-title":"World Neurosurg"},{"key":"pone.0319146.ref008","doi-asserted-by":"crossref","first-page":"e465","DOI":"10.1016\/j.wneu.2018.11.189","article-title":"Establishment and verification of the hematoma expansion prediction score of intracerebral hemorrhage in the qinghai-tibetan plateau","volume":"123","author":"CN Du","year":"2019","journal-title":"World Neurosurg"},{"issue":"4","key":"pone.0319146.ref009","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jclinepi.2010.09.012","article-title":"Grade guidelines: 2. Framing the question and deciding on important outcomes","volume":"64","author":"GH Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"pone.0319146.ref010","doi-asserted-by":"crossref","first-page":"h1225","DOI":"10.1136\/bmj.h1225","article-title":"Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials","volume":"350","author":"GC Machado","year":"2015","journal-title":"BMJ"},{"key":"pone.0319146.ref011","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.thromres.2022.02.024","article-title":"Risk of vte associated with ports and piccs in cancer patients: a systematic review and meta-analysis","volume":"213","author":"P Wang","year":"2022","journal-title":"Thromb Res"},{"key":"pone.0319146.ref012","first-page":"201","article-title":"Incidence rates of hospitalization related to traumatic brain injury--12 states, 2002","volume":"55","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"5","key":"pone.0319146.ref013","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/RCT.0000000000001343","article-title":"Prognostic value of different computed tomography scoring systems in patients with severe traumatic brain injury undergoing decompressive craniectomy","volume":"46","author":"ZJ Zhao","year":"2022","journal-title":"J Comput Assist Tomogr"},{"issue":"2","key":"pone.0319146.ref014","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pmr.2016.12.001","article-title":"Pathophysiology of traumatic brain injury","volume":"28","author":"KJ Dixon","year":"2017","journal-title":"Phys Med Rehabil Clin N Am"},{"issue":"1","key":"pone.0319146.ref015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1186\/s12883-021-02482-4","article-title":"Establishment and validation of prognosis model for patients with cerebral contusion","volume":"21","author":"Y Zhu","year":"2021","journal-title":"BMC Neurol"},{"issue":"1","key":"pone.0319146.ref016","doi-asserted-by":"crossref","first-page":"20574","DOI":"10.1038\/s41598-022-24824-z","article-title":"Establishment and validation of pte prediction model in patients with cerebral contusion","volume":"12","author":"S Lin","year":"2022","journal-title":"Sci Rep"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0319146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T18:32:42Z","timestamp":1740508362000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0319146"}},"subtitle":[],"editor":[{"given":"Pengpeng","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0319146","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]}}}