{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:54:04Z","timestamp":1773028444120,"version":"3.50.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec016\">\n<jats:title>Background<\/jats:title>\n<jats:p>The connection between sleep patterns (sleep duration, trouble sleeping and sleep disorders) and benign prostatic hyperplasia, commonly referred to as BPH, is not yet clear. Our aim is to investigate the impact of sleep patterns on BPH risk in US men aged 40 and older.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec017\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We performed an observational analysis using data from NHANES 2005\u20132008 on males aged 40 and up, including a total of 2,555 participants. After accounting for confounding variables, we applied weighted multivariable logistic regression to assess the relationship between sleep patterns and BPH risk according to the complex multi-stage sampling design of NHANES.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec018\">\n<jats:title>Results<\/jats:title>\n<jats:p>In this study, 11.79% of the 2,555 American participants aged over 40 reported to have BPH. after adjusting for confounding variables, multivariable logistic regression analysis showed that short sleep duration, compared to healthy sleep duration (7\u20139 hours), was linked to a significantly higher risk of BPH (OR: 1.92, 95% CI: 1.42\u20132.41). Trouble sleeping and sleep disorder were also strongly associated with BPH. Moreover, there appears to be a stronger association among those with poor sleep patterns (OR: 2.07, 95% CI: 1.46\u20132.91).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec019\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Poor sleep patterns in men over 40 in the U.S. is significantly linked to a higher incidence of benign prostatic hyperplasia.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0319434","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T18:23:36Z","timestamp":1740507816000},"page":"e0319434","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Poor sleep patterns are associated with the prevalence of benign prostatic hyperplasia in US aged 40 and older: A cross-sectional study based on NHANES"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4467-5392","authenticated-orcid":true,"given":"Dingliang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengsen","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"issue":"4","key":"pone.0319434.ref001","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ucl.2009.07.003","article-title":"Etiology, epidemiology, and natural history of benign prostatic hyperplasia","volume":"36","author":"W Bushman","year":"2009","journal-title":"Urol Clin North Am"},{"issue":"11","key":"pone.0319434.ref002","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1016\/S2666-7568(22)00213-6","article-title":"The global, regional, and national burden of benign prostatic hyperplasia in 204 countries and territories from 2000 to 2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"3","author":"GBD 2019 Benign Prostatic Hyperplasia Collaborators","year":"2022","journal-title":"Lancet Healthy Longev"},{"issue":"Suppl 3","key":"pone.0319434.ref003","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1038\/ijir.2008.55","article-title":"Pathology of benign prostatic hyperplasia","volume":"20","author":"C Roehrborn","year":"2008","journal-title":"Int J Impot Res"},{"issue":"3","key":"pone.0319434.ref004","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1056\/NEJMcp1106637","article-title":"Clinical practice. 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