{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:48:46Z","timestamp":1767772126831,"version":"3.40.1"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001063","name":"Crohn's and Colitis Foundation of America","doi-asserted-by":"publisher","award":["1167823"],"award-info":[{"award-number":["1167823"]}],"id":[{"id":"10.13039\/100001063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Crohn\u2019s disease (CD) is a long-term inflammatory gastrointestinal disorder, often adversely affecting physical, emotional, and psychological well-being. Pharmaceutical management is habitually adopted; although medicinal therapies require continuous administration, and\u00a0are often\u00a0associated with significant side effects and low adherence rates. Whole body vibration (WBV) represents a non-invasive technique, that provides vibration stimulation to the entire body. As WBV appears to target the physiological pathways and symptoms pertinent to CD epidemiology, it may have significant potential as a novel non-pharmaceutical intervention therapy in CD. This paper presents the study protocol for a randomised controlled trial investigating the impact of WBV on health outcomes in individuals with CD. This 6-week, parallel randomised controlled trial will recruit 168 individuals, assigned to receive WBV and lifestyle education 3 times per week compared to control, receiving lifestyle education only. The primary outcome of the trial will be the difference from baseline to post-intervention in health-related quality of life between the groups, assessed with the Inflammatory Bowel Disease Quality of Life Questionnaire. Secondary outcomes will include between-group differences in other questionnaires assessing fatigue, anxiety and pain, measures of physical fitness, and biological markers for disease activity and inflammation. Statistical analyses will follow an intention-to-treat approach, using linear mixed-effects models to compare changes between time points and both trial groups. Ethical approval was granted by the Nottingham Research Ethics Committee <jats:italic>(REC: 24\/EM\/0106)<\/jats:italic> and the study has been registered prospectively as a clinical trial (NTC06211400).<\/jats:p>","DOI":"10.1371\/journal.pone.0319685","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T18:35:46Z","timestamp":1742409346000},"page":"e0319685","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vibrational exercise for Crohn\u2019s to observe response (VECTOR): Protocol for a randomized controlled trial"],"prefix":"10.1371","volume":"20","author":[{"given":"Jonathan","family":"Sinclair","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Brooks-Warburton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-4448","authenticated-orcid":true,"given":"Amit N.","family":"Pujari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Jewiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-3764","authenticated-orcid":true,"given":"Lindsay","family":"Bottoms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"issue":"1","key":"pone.0319685.ref001","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1136\/flgastro-2013-100339","article-title":"Inflammatory bowel disease and exercise: results of a Crohn\u2019s and Colitis UK survey","volume":"5","author":"D Chan","year":"2013","journal-title":"Frontline Gastroenterol"},{"issue":"4","key":"pone.0319685.ref002","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/MOG.0b013e32836229fb","article-title":"Inflammatory bowel disease epidemiology","volume":"29","author":"J Burisch","year":"2013","journal-title":"Current Opinion in Gastroenterology"},{"key":"pone.0319685.ref003","first-page":"51","article-title":"Report: economic implications of inflammatory bowel disease and its management","volume":"22","author":"F Mehta","year":"2016","journal-title":"American Journal of Managed Care"},{"key":"pone.0319685.ref004","article-title":"Genetics of inflammatory bowel disease from multifactorial to monogenic forms","author":"AM Bianco","year":"2015","journal-title":"World J Gastroenterol"},{"key":"pone.0319685.ref005","article-title":"Inflammatory bowel disease: clinical aspects and treatments","author":"M Fakhoury","year":"2014","journal-title":"J Inflamm Res"},{"key":"pone.0319685.ref006","article-title":"The role of physical exercise in inflammatory bowel disease","author":"J Bilski","year":"2014","journal-title":"Biomed Res Int"},{"key":"pone.0319685.ref007","article-title":"A comprehensive review and update on Crohn\u2019s disease","author":"M Gajendran","year":"2018","journal-title":"Dis Mon"},{"key":"pone.0319685.ref008","article-title":"Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds","author":"AA Chumanevich","year":"2017","journal-title":"Oncotarget"},{"key":"pone.0319685.ref009","article-title":"Exercise in patients with inflammatory bowel diseases: current perspectives","author":"M Engels","year":"2017","journal-title":"Clin Exp Gastroenterol"},{"key":"pone.0319685.ref010","doi-asserted-by":"crossref","first-page":"575231","DOI":"10.3389\/fmed.2020.00517","article-title":"Personalizing treatment in IBD: hype or reality in 2020? 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