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Forty volunteers were randomly assigned to two groups: the tACS and the control. The experiment was divided into three distinct stages: pre-stimulation, stimulation, and post-stimulation. The Stroop Color-Word Task (SCWT) was employed as a validated stress-inducing paradigm to assess pre- and post-stimulation changes. During the initial phase, the participants completed the SCWT. This was followed by either tACS or sham. In the third session, the individuals solved the task again. The anode and cathode for the transcranial tACS were placed on the dorsolateral prefrontal cortex (DLPFC). tACS, was applied with current intensity of 1.5 mA at 16 Hz over the dorsolateral prefrontal cortex (DLPFC), aimed to modulate cortical activation and mitigate stress. Sham included 5-second ramp periods. Physiological data using alpha amylase and the NASA Task Load Index (NASA-TLX) were utilized. The results revealed significant hemodynamic changes and reduced stress levels in the tACS group compared to the sham group (<jats:italic>p<\/jats:italic> &lt;\u2009 0.001). The connectivity network changed significantly (<jats:italic>p<\/jats:italic> &lt;\u2009 0.001) following tACS. In addition, the NASA-TLX results showed a statistically significant difference between the pre-and post-tACS sessions. In contrary, no statistical significance was noticed for the sham control group. An increase in the blood flow in the prefrontal cortex region of the brain was observed, demonstrating the potential of tACS as a non-invasive neuromodulation technique for stress mitigation.<\/jats:p>","DOI":"10.1371\/journal.pone.0319702","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T19:49:19Z","timestamp":1743018559000},"page":"e0319702","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of transcranial alternating current stimulation on psychological stress: A functional near-infrared spectroscopy study"],"prefix":"10.1371","volume":"20","author":[{"given":"M. N. Afzal","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara","family":"Badr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8725-7487","authenticated-orcid":true,"given":"Sandra 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