{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:54:50Z","timestamp":1787507690880,"version":"build-2736575974"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AO from Regional Research Council Mid Sweden.","award":["357901 SEK"],"award-info":[{"award-number":["357901 SEK"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Home phototherapy is recommended as an alternative to hospital-based therapy for neonatal jaundice in otherwise healthy full-term infants. With a reliable device for transcutaneous bilirubin (TcB) measurement, bilirubin values could be monitored at home during treatment. This study aimed to examine the accuracy of TcB measurement of bilirubin levels before, during, and after home phototherapy. Patients requiring phototherapy were assigned to home (intervention) or hospital-based phototherapy (control). Transcutaneous bilirubin measurement was made at the sternum (uncovered skin) and at sacrum (covered by the diaper during treatment). Simultaneously, total serum bilirubin (TSB) level was collected through a blood sample. The agreement between TcB and TSB before, during, and after phototherapy was assessed using Bland-Altman plots. Altogether 141 patients and 856 paired bilirubin values were included. The results show that TcB measurements underestimate TSB levels. Before phototherapy, the mean difference between TcB and TSB was 75\u2009\u00b1\u200936 \u03bcmol\/L at the sternum and 135\u2009\u00b1\u200939 \u03bcmol\/L at sacrum, with no difference between study groups. During phototherapy, the mean difference at the sternum was larger in the control group, 105\u2009\u00b1\u200973 \u03bcmol\/L, than in the intervention group, 50\u2009\u00b1\u200941 \u03bcmol\/L; at sacrum, the mean difference was 125\u2009\u00b1\u200944 \u03bcmol\/L, comparable in both study groups. After phototherapy, the TcB\u2013TSB agreement improved, with a mean difference of 29\u2009\u00b1\u200933 \u03bcmol\/L (sternum) and 87\u2009\u00b1\u200935 \u03bcmol\/L (sacrum), and no difference between study groups. In conclusion this study shows that full-term infants who qualified for phototherapy show poor agreement between TcB measurement and TSB, suggesting that TcB measurements cannot replace measurement of TSB level before, during, or after home phototherapy.<\/jats:p>","DOI":"10.1371\/journal.pone.0320067","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T15:23:58Z","timestamp":1742916238000},"page":"e0320067","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcutaneous bilirubin in newborns before, during, and after home phototherapy\u2014Results from a secondary analysis of a randomized controlled trial"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2995-0280","authenticated-orcid":true,"given":"Felicia","family":"Erlandsson 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