{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:40:56Z","timestamp":1785231656322,"version":"3.55.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec025\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>The optimal intravenous fluid for kidney transplantation (KT) is still controversial. This meta-analysis aimed to compare the efficacy and safety of plasma-lyte solution (PL) versus saline (NS) in kidney transplantation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec026\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>A comprehensive search was conducted across four databases (PubMed, Embase, Web of Science, and the Cochrane Library) to identify relevant randomized controlled trials (RCTs) comparing plasma-lyte and saline in kidney transplantation. Risk of bias was assessed using the Cochrane RoB 2.0 tool. Meta-analyses of delayed graft function (DGF), creatinine levels, urine output, blood pH, bicarbonate, base excess, electrolytes, serum chloride, potassium and sodium immediately post-surgery were performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec027\">\n<jats:title>Results<\/jats:title>\n<jats:p>Totally six randomized controlled studies with 1197 patients were included. In comparison to the NS group, the PL group exhibited a significantly lower incidence of DGF (OR: 0.66, 95% CI: 0.51 to 0.86, P =\u2009 0.002) and reduced serum chloride (MD: -8.87, 95% CI: -13.50 to -4.25, P\u2009=\u20090.0002) as well as serum sodium(MD: -1.08, 95% CI: -1.54 to -0.61, P &lt;\u2009 0.00001), while blood pH(MD: 0.05, 95% CI: 0.03 to 0.07, P &lt;\u2009 0.00001), bicarbonate (MD: 2.09, 95% CI: 1.21 to 2.97, P\u2009=\u20090.005), and base excess levels (MD: 2.42, 95% CI: 0.72 to 4.11, P &lt;\u2009 0.00001) were significantly elevated. No statistically significant differences were observed in creatinine, urine output, or potassium concentrations between two groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec028\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This meta-analysis compared the efficacy and safety between plasma-lyte and saline in kidney transplantation. Plasma-lyte reduced delayed graft function in kidney transplant compared to saline.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec029\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>PROSPERO (CRD42024588701).<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0320082","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T17:35:55Z","timestamp":1744220155000},"page":"e0320082","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma-lyte solution versus saline in kidney transplantation: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1371","volume":"20","author":[{"given":"Yucai","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijian","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6847-2545","authenticated-orcid":true,"given":"Jian","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"issue":"10041","key":"pone.0320082.ref001","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0140-6736(16)30448-2","article-title":"Factors 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