{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:59:55Z","timestamp":1783396795367,"version":"3.54.6"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J01543"],"award-info":[{"award-number":["2023J01543"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Startup Project for High-level Talents of Fujian Medical University","award":["XRCZX2020016"],"award-info":[{"award-number":["XRCZX2020016"]}]},{"DOI":"10.13039\/501100001809","name":"the National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["82402662"],"award-info":[{"award-number":["82402662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Fujian Medical University Qihang Fund","award":["2021QH1005"],"award-info":[{"award-number":["2021QH1005"]}]},{"name":"the Education and Scientific Research Project for Young and Middle-aged Teachers in Fujian Province","award":["JAT210116"],"award-info":[{"award-number":["JAT210116"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Dengue fever, transmitted by <jats:italic>Aedes albopictus<\/jats:italic> in China, is a major public health issue. The emergence of <jats:italic>kdr<\/jats:italic> gene mutations in <jats:italic>Ae. albopictus<\/jats:italic> has reduced the efficacy of insecticide-based control. We investigated the genetic structure of eight <jats:italic>Ae. albopictus<\/jats:italic> populations from China\u2019s southeastern coastal region, analyzing genetic diversity, population structure, and the prevalence of <jats:italic>kdr<\/jats:italic> mutations in relation to dengue fever incidence. Allelic diversity was moderate, with the number of alleles ranging from 2 to 6 and effective number of alleles from 1.52 to 5.00. Genetic clustering revealed four groups with 0.71% to 1.81% variation, indicating moderate differentiation. The coefficient of genetic differentiation value was 0.07 to 0.18, and Nm values 1.13 to 3.25. Except for Foshan and Sanming, four populations showed deltamethrin resistance, 4.31 to 18.87-fold. The <jats:italic>voltage-gated sodium channel (<\/jats:italic>VGSC) gene analysis identified non-synonymous mutations, with I1532 mutations absent in Sanming and F1534 present in all. Four populations showed resistance to deltamethrin, with resistance levels varying significantly. The VGSC gene analysis revealed multiple non-synonymous mutations associated with resistance, particularly at positions I1532 and F1534. No significant correlation was found between dengue fever incidence, <jats:italic>kdr<\/jats:italic> mutations, and genetic indicators, indicating a consistent potential for disease transmission. However, populations with higher genetic diversity had lower frequencies of F1534 and higher frequencies of I1532I mutations. The findings underscore the significant influence of <jats:italic>kdr<\/jats:italic> mutations on the effectiveness of mosquito control strategies. The presence of these mutations necessitates the implementation of alternative insecticides and integrated pest management approaches to sustainably reduce <jats:italic>Ae. albopictus<\/jats:italic> populations and mitigate the spread of dengue fever.<\/jats:p>","DOI":"10.1371\/journal.pone.0320200","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T21:14:41Z","timestamp":1743023681000},"page":"e0320200","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic structure and knockdown resistance (kdr) mutations in Aedes albopictus (Skuse) (Diptera: Culicidae): Implications for dengue fever transmission in southeastern China"],"prefix":"10.1371","volume":"20","author":[{"given":"Shi-Yuan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ling","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-009X","authenticated-orcid":true,"given":"Li-Hua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"issue":"6","key":"pone.0320200.ref001","doi-asserted-by":"crossref","first-page":"e2021055522","DOI":"10.1542\/peds.2021-055522","article-title":"Dengue: A Growing Problem With New Interventions","volume":"149","author":"JM Wong","year":"2022","journal-title":"Pediatrics"},{"issue":"9","key":"pone.0320200.ref002","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1016\/j.sjbs.2021.05.023","article-title":"Dengue and human health: A global scenario of its occurrence, diagnosis and therapeutics","volume":"28","author":"MJ Sabir","year":"2021","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"pone.0320200.ref003","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40249-023-01096-x","article-title":"Genetic structure of Aedes albopictus (Diptera: Culicidae) populations in China and relationship with the knockdown resistance mutations","volume":"12","author":"W Shan","year":"2023","journal-title":"Infect Dis Poverty"},{"issue":"8","key":"pone.0320200.ref004","first-page":"914","article-title":"Population genetic diversity analysis of the dengue vector Aedes albopictus in China %","volume":"24","author":"Y Zhang","year":"2024","journal-title":"J China Tropical Medicine"},{"key":"pone.0320200.ref005","doi-asserted-by":"crossref","unstructured":"Wei Y. 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