{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:44:52Z","timestamp":1754145892545,"version":"3.41.2"},"reference-count":163,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>In multidisciplinary research interpreting interactions between diverse data sources requires a Complexity approach. A Complex Adaptive Systems (CAS) framework allows the relationships of multiple factors to be explored and may provide a more holistic and nuanced understanding. This study is innovative in explaining the potential benefits in a CAS approach to combining bioarchaeological and historical data when examining a rare archaeological skeletal sample of early migrants to South Australia (SA). Macroscopic, radiographic and micro-CT methods were used for the analysis of the skeletal remains of a group of 19<jats:sup>th<\/jats:sup> century migrants buried in an unmarked area of St Mary\u2019s Anglican Church Cemetery. The relevant historical records explored were from British emigrant ships to SA (1836\u20131885 CE) and the Church burial records (1847\u20131885 CE). Evidence of poor oral and general health was present in the skeletal material. Dental developmental defects indicated health insults in early life. Pathological manifestations in bone were compatible with joint and infectious diseases, and metabolic deficiencies. Historical documents recorded that the voyages to SA were challenging, with some ships experiencing a high death rate. Diseases, e.g., measles and scarlet fever, and diarrhoea were frequently recorded as causes of death at sea for both non-adults and adults. In the Colony, burial records showed similar causes of death for non-adults, but for adults, accidents and tuberculosis were often reported. The CAS approach provided insights beyond those from analysis of the individual sources. It increased understanding of emergent, non-predicted outcomes that resulted from interactions between multiple factors, the impact of fluctuating economy, political instability and ideological pressures, on the health of migrants. The CAS framework is a valuable methodology for interpreting health patterns and can be further developed including for a range of historical and contemporary health contexts.<\/jats:p>","DOI":"10.1371\/journal.pone.0320268","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T17:49:58Z","timestamp":1752774598000},"page":"e0320268","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complex traces: Examining morbidity and mortality among 19th Century migrants to South Australia using a Complex Adaptive Systems framework"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-9130","authenticated-orcid":true,"given":"Angela","family":"Gurr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Brook 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Blackman","year":"2019"},{"key":"pone.0320268.ref015","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781139225731","volume-title":"Reforming ideas in Britain: politics and language in the shadow of the French Revolution, 1789\u20131815","author":"M Philp","year":"2013"},{"issue":"3","key":"pone.0320268.ref016","first-page":"335","article-title":"The impact of the revolutionary and Napoleonic wars, 1793-1815, on the long-run growth of the British economy","volume":"12","author":"PK O\u2019Brien","year":"1989","journal-title":"Review - Fernand Braudel Center for the Study of Economies, Historical Systems, and Civilizations"},{"key":"pone.0320268.ref017","doi-asserted-by":"crossref","DOI":"10.1515\/9781782043188","volume-title":"British expeditionary warfare and the defeat of Napoleon, 1793\u20131815","author":"RK Sutcliffe","year":"2016"},{"key":"pone.0320268.ref018","volume-title":"Commemorating Peterloo: Violence, Resilience and Claim-making during the Romantic Era","author":"M Demson","year":"2019"},{"issue":"1","key":"pone.0320268.ref019","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/02665438808725652","article-title":"Systematic colonization and town planning in Australia and New Zealand","volume":"3","author":"R Bunker","year":"1988","journal-title":"Planning Perspectives"},{"key":"pone.0320268.ref020","volume-title":"Founders & pioneers of South Australia: life studies of Edward Gibbon Wakefield, Charles Sturt, George Fife Angas, Sir John Hindmarsh, William Light, George Gawler, David McLaren, Augustus Kavell, and Francis Cadell","author":"AG Price","year":"1929"},{"key":"pone.0320268.ref021","volume-title":"A letter from Sydney, the principal town of Australasia","author":"EG Wakefield","year":"1829"},{"issue":"1","key":"pone.0320268.ref022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0022050705050011","article-title":"Rural-Urban Migration and Socioeconomic Mobility in Victorian Britain","volume":"65","author":"J Long","year":"2005","journal-title":"J Econ Hist"},{"issue":"4","key":"pone.0320268.ref023","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2307\/2137377","article-title":"Economic Growth, Disruption, Deprivation, Disease, and Death: On the Importance of the Politics of Public Health for Development","volume":"23","author":"S Szreter","year":"1997","journal-title":"Population and Development Review"},{"key":"pone.0320268.ref024","first-page":"165","article-title":"Urbanization, mortality, and the standard of living debate: New estimates of the expectation of life at birth in nineteenth-century British cities","volume-title":"United States","author":"S Szreter","year":"2005"},{"issue":"12","key":"pone.0320268.ref025","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/0004-6981(77)90091-9","article-title":"London air pollution, 1500-1900","volume":"11","author":"P Brimblecombe","year":"1977","journal-title":"Atmos 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Perschbacher","year":"2014"},{"issue":"1","key":"pone.0320268.ref067","first-page":"21","article-title":"Is root exposure a good marker of periodontal disease?","volume":"15","author":"A Riga","year":"2021","journal-title":"Bulletin of the International Association of Paleodontology"},{"key":"pone.0320268.ref068","first-page":"59","author":"AH Brook","year":"2001","journal-title":"The development of a new index to measure enamel defects. 12th International Symposium on Dental Morphology 20012001"},{"key":"pone.0320268.ref069","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0722.2006.00294.x","article-title":"The new Enamel Defects Index: testing and expansion","volume":"114","author":"C Elcock","year":"2006","journal-title":"European Journal of Oral Sciences"},{"issue":"2","key":"pone.0320268.ref070","first-page":"159","article-title":"An epidemiological index of developmental defects of dental enamel (DDE Index). Commission on Oral Health, Research and Epidemiology","volume":"32","year":"1982","journal-title":"Int Dent J"},{"issue":"6","key":"pone.0320268.ref071","first-page":"411","article-title":"A review of the developmental defects of enamel index (DDE Index). Commission on Oral Health, Research & Epidemiology. Report of an FDI Working Group","volume":"42","year":"1992","journal-title":"International dental journal"},{"key":"pone.0320268.ref072","first-page":"390","article-title":"Micro-computed tomography of teeth as an alternative way to detect and analyse vitamin D deficiency","volume":"23","author":"A Colombo","year":"2019","journal-title":"Journal of Archaeological Science: Reports"},{"issue":"1","key":"pone.0320268.ref073","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/ajpa.23819","article-title":"Micro-CT assessment of dental mineralization defects indicative of vitamin D deficiency in two 17th-19th century Dutch communities","volume":"169","author":"B Veselka","year":"2019","journal-title":"Am J Phys Anthropol"},{"key":"pone.0320268.ref074","volume-title":"Human osteology: a laboratory and field manual","author":"WM Bass","year":"1995"},{"key":"pone.0320268.ref075","volume-title":"Standards for data collection from human skeletal remains: proceedings of a seminar at the Field Museum of Natural History","author":"JE Buikstra","year":"1994"},{"key":"pone.0320268.ref076","volume-title":"Developmental Juvenile Osteology","author":"L Scheuer","year":"2000"},{"key":"pone.0320268.ref077","first-page":"719","article-title":"Chapter 20 - Joint Disease","volume-title":"Third Edition","author":"T Waldron","year":"2019"},{"key":"pone.0320268.ref078","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijpp.2019.12.004","article-title":"Back to the beginning: Identifying lesions of diffuse idiopathic skeletal hyperostosis prior to vertebral ankylosis","volume":"28","author":"L Castells Navarro","year":"2020","journal-title":"Int J Paleopathol"},{"issue":"6","key":"pone.0320268.ref079","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/oa.794","article-title":"Skeletal manifestations of vitamin D deficiency osteomalacia in documented historical collections","volume":"15","author":"M Brickley","year":"2005","journal-title":"Int J Osteoarchaeol"},{"issue":"4","key":"pone.0320268.ref080","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/ajpa.23701","article-title":"Cribra orbitalia and porotic hyperostosis: A biological approach to diagnosis","volume":"167","author":"MB Brickley","year":"2018","journal-title":"Am J Phys Anthropol"},{"key":"pone.0320268.ref081","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-08-101020-4.00002-1","volume-title":"The Bioarchaeology of Metabolic Bone Disease","author":"MB Brickley","year":"2020"},{"key":"pone.0320268.ref082","first-page":"531","article-title":"Metabolic Disease","volume-title":"Third Edition","author":"MB Brickley","year":"2019"},{"key":"pone.0320268.ref083","doi-asserted-by":"crossref","DOI":"10.1002\/9781444345940.ch22","volume-title":"Metabolic and Endocrine Diseases","author":"T Koz\u0142owski","year":"2011"},{"issue":"3","key":"pone.0320268.ref084","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/(SICI)1099-1212(199705)7:3<212::AID-OA346>3.0.CO;2-5","article-title":"Bone changes in the human skull probably resulting from scurvy in infancy and childhood","volume":"7","author":"DJ Ortner","year":"1997","journal-title":"Int J Osteoarchaeol"},{"issue":"3","key":"pone.0320268.ref085","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/(SICI)1096-8644(199903)108:3<321::AID-AJPA7>3.0.CO;2-7","article-title":"Probable evidence of scurvy in subadults from archeological sites in Peru","volume":"108","author":"DJ Ortner","year":"1999","journal-title":"Am J Phys Anthropol"},{"issue":"1","key":"pone.0320268.ref086","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/(SICI)1099-1212(199801\/02)8:1<45::AID-OA405>3.0.CO;2-D","article-title":"Dry-bone manifestations of rickets in infancy and early childhood","volume":"8","author":"DJ Ortner","year":"1998","journal-title":"Int J Osteoarchaeol"},{"issue":"4","key":"pone.0320268.ref087","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/ajpa.23699","article-title":"Macroscopic features of scurvy in human skeletal remains: A literature synthesis and diagnostic guide","volume":"167","author":"AME Snoddy","year":"2018","journal-title":"Am J Phys Anthropol"},{"key":"pone.0320268.ref088","first-page":"101","article-title":"Anaemia in Roman Britain: Poundbury Camp.","volume-title":"Health in Past Societies: Biocultural Interpretations of Human Skeletal Remains in Archaeological Contexts","author":"P. Stuart-Macadam","year":"1991"},{"key":"pone.0320268.ref089","first-page":"285","article-title":"Chapter 10 - Infectious Disease: Introduction, Periostosis, Periostitis, Osteomyelitis, and Septic Arthritis","volume-title":"Third Edition","author":"CA Roberts","year":"2019"},{"key":"pone.0320268.ref090","first-page":"321","article-title":"Bacterial Infections","volume-title":"Third Edition","author":"CA Roberts","year":"2019"},{"key":"pone.0320268.ref091","author":"S Ioannou","year":"2017"},{"issue":"4","key":"pone.0320268.ref092","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1515\/anre-2017-0032","article-title":"Dental signs attributed to congenital syphilis and its treatments in the Hamann-Todd Skeletal Collection","volume":"80","author":"S Ioannou","year":"2017","journal-title":"AR"},{"issue":"4","key":"pone.0320268.ref093","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/ajpa.22924","article-title":"Diagnosing congenital syphilis using Hutchinson\u2019s method: Differentiating between syphilitic, mercurial, and syphilitic-mercurial dental defects","volume":"159","author":"S Ioannou","year":"2016","journal-title":"Am J Phys Anthropol"},{"key":"pone.0320268.ref094","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/103842","article-title":"Diagnosis of Mercurial Teeth in a Possible Case of Congenital Syphilis and Tuberculosis in a 19th Century Child Skeleton","volume":"2015","author":"S Ioannou","year":"2015","journal-title":"Journal of Anthropology"},{"key":"pone.0320268.ref095","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.archoralbio.2017.10.017","article-title":"Presence of dental signs of congenital syphilis in pre-modern specimens","volume":"85","author":"S Ioannou","year":"2018","journal-title":"Arch Oral Biol"},{"key":"pone.0320268.ref096","first-page":"211","article-title":"Trauma","volume-title":"Third Edition","author":"R Redfern","year":"2019"},{"key":"pone.0320268.ref097","first-page":"337","article-title":"Trauma in biocultural perspective: Past, present and future work in Britain.","volume-title":"Human osteology in archaeology and forensic science","author":"C. Roberts","year":"2000"},{"issue":"4","key":"pone.0320268.ref098","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10814-015-9084-1","article-title":"The Osteological Paradox 20 Years Later: Past Perspectives, Future Directions","volume":"23","author":"SN DeWitte","year":"2015","journal-title":"J Archaeol Res"},{"issue":"4","key":"pone.0320268.ref099","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1086\/204084","article-title":"The Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples [and Comments and Reply]","volume":"33","author":"JW Wood","year":"1992","journal-title":"Current Anthropology"},{"key":"pone.0320268.ref100","first-page":"34","article-title":"Deaths On-board Immigrant Ships 1849-1865","volume-title":"South Australia","author":"GoSA A-G","year":"2016"},{"key":"pone.0320268.ref101","year":"2022"},{"key":"pone.0320268.ref102","author":"D Cummings","year":"2017"},{"key":"pone.0320268.ref103","author":"Government of South Australia","year":"1866"},{"key":"pone.0320268.ref104","author":"British Parliament","year":"1847"},{"key":"pone.0320268.ref105","article-title":"Man questioned over St Mary\u2019s church fire","author":"News T","year":"1953","journal-title":"The News"},{"key":"pone.0320268.ref106","article-title":"Fire Badly Damages Old Church","year":"1953","journal-title":"The Advertiser"},{"issue":"6","key":"pone.0320268.ref107","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/oa.902","article-title":"Pathogenesis of apical periodontal cysts: guidelines for diagnosis in palaeopathology","volume":"17","author":"GJ Dias","year":"2007","journal-title":"Intl J of Osteoarchaeology"},{"issue":"1","key":"pone.0320268.ref108","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/jech-2015-206745","article-title":"Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60\u2005174 participants in a large dental school in the Netherlands","volume":"71","author":"NGFM Beukers","year":"2017","journal-title":"J Epidemiol Community Health"},{"issue":"1","key":"pone.0320268.ref109","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3233\/JAD-200064","article-title":"Clinical and Bacterial Markers of Periodontitis and Their Association with Incident All-Cause and Alzheimer\u2019s Disease Dementia in a Large National Survey","volume":"75","author":"MA Beydoun","year":"2020","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"pone.0320268.ref110","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/jcpe.13341","article-title":"Association between periodontal disease, tooth loss and liver diseases risk","volume":"47","author":"Y Chen","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"9","key":"pone.0320268.ref111","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1161\/01.STR.0000085086.50957.22","article-title":"Relationship between periodontal disease, tooth loss, and carotid artery plaque: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)","volume":"34","author":"M Desvarieux","year":"2003","journal-title":"Stroke"},{"issue":"1","key":"pone.0320268.ref112","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/prd.12430","article-title":"Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications","volume":"89","author":"G Hajishengallis","year":"2022","journal-title":"Periodontol 2000"},{"key":"pone.0320268.ref113","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1600-0501.2007.01436.x","article-title":"What dentition assures oral function?","author":"K Gotfredsen","year":"2007","journal-title":"Clin Oral Implants Res"},{"key":"pone.0320268.ref114","doi-asserted-by":"crossref","DOI":"10.1016\/S0002-9343(97)00334-3","article-title":"Effects of gastroesophageal reflux on the oral cavity","volume":"103","author":"DA Lazarchik","year":"1997","journal-title":"Am J Med"},{"issue":"6","key":"pone.0320268.ref115","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jdent.2004.03.004","article-title":"Dental erosion, gastro-oesophageal reflux disease and saliva: how are they related?","volume":"32","author":"R Moazzez","year":"2004","journal-title":"J Dent"},{"issue":"1","key":"pone.0320268.ref116","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1440-1746.2011.06945.x","article-title":"Oral manifestations of gastroesophageal reflux disease","volume":"27","author":"S Ranjitkar","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"pone.0320268.ref117","volume-title":"Merriam-Webster\u2019s medical dictionary","year":"2016"},{"issue":"3932","key":"pone.0320268.ref118","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(01)78998-2","article-title":"\u201cWhat is tabes mesenterica in infants?\u201d","volume":"153","year":"1899","journal-title":"The Lancet"},{"issue":"3","key":"pone.0320268.ref119","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1001\/archpedi.1912.04100150039003","article-title":"Atrophy of infants","author":"AD Czerny","year":"1912","journal-title":"Arch Pediatr Adolesc Med"},{"key":"pone.0320268.ref120","volume-title":"A history of the Royal Adelaide Hospital","author":"JE Hughes","year":"1982"},{"issue":"2","key":"pone.0320268.ref121","doi-asserted-by":"crossref","first-page":"104","DOI":"10.7196\/SAMJ.5243","article-title":"Management guidelines for acute infective diarrhoea \/ gastroenteritis in infants","volume":"102","author":"DF Wittenberg","year":"2012","journal-title":"S Afr Med J"},{"issue":"4","key":"pone.0320268.ref122","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/NOR.0000000000000775","article-title":"Spina Bifida Occulta","volume":"40","author":"P Graham","year":"2021","journal-title":"Orthop Nurs"},{"key":"pone.0320268.ref123","volume-title":"Rations, residence, resources: a history of social welfare in South Australia since 1836","author":"B. Dickey","year":"1986"},{"key":"pone.0320268.ref124","volume-title":"Paradise of dissent: South Australia 1829-1857","author":"D Pike","year":"1957"},{"key":"pone.0320268.ref125","volume-title":"Diary of Dr George Mayo","author":"G Mayo","year":"1839"},{"key":"pone.0320268.ref126","volume-title":"Royal South Australian almanack for 1839. Containing a daily calendar\u2026and all useful information regarding the province of South Australia","year":"1969"},{"key":"pone.0320268.ref127","unstructured":"Cummings D. Bound for South Australia. Collections. https:\/\/bound-for-south-australia.collections.slsa.sa.gov.au\/1849Elgin.htm. 2017. 2024 February 10."},{"key":"pone.0320268.ref128","doi-asserted-by":"crossref","DOI":"10.1057\/9780230248427","volume-title":"Doctors at sea: emigrant voyages to colonial Australia","author":"R Haines","year":"2005"},{"key":"pone.0320268.ref129","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195135442.001.0001","volume-title":"Cholera, chloroform, and the science of medicine: a life of John Snow","author":"P Vinten-Johansen","year":"2003"},{"key":"pone.0320268.ref130","article-title":"The cholera","year":"1851","journal-title":"Adelaide Observer"},{"key":"pone.0320268.ref131","article-title":"The James Fernie","year":"1854","journal-title":"Adelaide Times"},{"key":"pone.0320268.ref132","article-title":"The Lord of the Isles","year":"1854","journal-title":"South Australian Register"},{"key":"pone.0320268.ref133","article-title":"The Star Queen","year":"1855","journal-title":"South Australian Register"},{"key":"pone.0320268.ref134","first-page":"43","article-title":"The wreck of the Nashwauk, Moana, SA 1855","volume":"32","author":"JH Callen","year":"2004","journal-title":"Journal of the Historical Society of South Australia"},{"key":"pone.0320268.ref135","author":"South Australian Government","year":"1866"},{"issue":"2","key":"pone.0320268.ref136","first-page":"29","article-title":"History of tuberculosis. Part 1 - phthisis, consumption and the white plague","volume":"22","author":"J Frith","year":"2014","journal-title":"Journal of Military and Veterans\u2019 Health"},{"issue":"2","key":"pone.0320268.ref137","first-page":"129","article-title":"The intrauterine origins of cardiovascular and obstructive lung disease in adult life. The Marc Daniels Lecture 1990","volume":"25","author":"DJ Barker","year":"1991","journal-title":"J R Coll Physicians Lond"},{"issue":"4","key":"pone.0320268.ref138","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1471-0528.1992.tb13719.x","article-title":"Fetal growth and adult disease","volume":"99","author":"DJ Barker","year":"1992","journal-title":"Br J Obstet Gynaecol"},{"key":"pone.0320268.ref139","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/bmb\/60.1.5","article-title":"The thrifty phenotype hypothesis","volume":"60","author":"CN Hales","year":"2001","journal-title":"Br Med Bull"},{"issue":"3","key":"pone.0320268.ref140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/(SICI)1096-9136(199703)14:3<189::AID-DIA325>3.0.CO;2-3","article-title":"The Thrifty Phenotype Hypothesis: How Does it Look After 5 Years?","volume":"14","author":"CN Hales","year":"1997","journal-title":"Diabet Med"},{"issue":"1","key":"pone.0320268.ref141","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/humupd\/dmt043","article-title":"Transgenerational developmental programming","volume":"20","author":"CE Aiken","year":"2014","journal-title":"Hum Reprod Update"},{"issue":"1449","key":"pone.0320268.ref142","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1098\/rstb.2004.1518","article-title":"The developmental origins of well-being","volume":"359","author":"DJP Barker","year":"2004","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"2","key":"pone.0320268.ref143","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000273066","article-title":"Developmental origins of adult disease","volume":"19","author":"SC Langley-Evans","year":"2010","journal-title":"Med Princ Pract"},{"key":"pone.0320268.ref144","volume-title":"Developmental origins of health and disease","author":"L Poston","year":"2023"},{"issue":"2","key":"pone.0320268.ref145","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1017\/mdh.2018.3","article-title":"\u201cCleanse or Die\u201d: British Naval Hygiene in the Age of Steam, 1840-1900","volume":"62","author":"EJ Smith","year":"2018","journal-title":"Med Hist"},{"issue":"4","key":"pone.0320268.ref146","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1080\/00253359.2005.10656970","article-title":"Watering the fleet and the introduction of distillation","volume":"91","author":"EM Diamond","year":"2005","journal-title":"The Mariner\u2019s Mirror"},{"key":"pone.0320268.ref147","volume-title":"The Statutes of the United Kingdom of Great Britain and Ireland 18 & 19 Victoria","author":"HoC Parliament of Great Britain","year":"1854"},{"key":"pone.0320268.ref148","volume-title":"Prices, wages, and welfare in early colonial South Australia, 1836-1850","author":"S La C","year":"2019"},{"key":"pone.0320268.ref149","volume-title":"The South Australian Gazette: Average Daily Returns of Unemployed Immigrants, Destitute Poor and Sick, Supported by Government","author":"Government of South Australia","year":"1858"},{"key":"pone.0320268.ref150","volume-title":"Irish women in the Antipodes: foregrounded","author":"S Arthure","year":"2024"},{"key":"pone.0320268.ref151","author":"CW Parkin","year":"1964"},{"key":"pone.0320268.ref152","volume-title":"Servants depots in colonial South Australia","author":"MA Steiner","year":"2008"},{"key":"pone.0320268.ref153","volume-title":"Behind the wall: the women of the destitute asylum Adelaide, 1852-1918","author":"M Geyer","year":"1994"},{"issue":"45","key":"pone.0320268.ref154","first-page":"63","article-title":"Accommodating the destitute. An historical and archaeological consideration of the destitute asylum of Adelaide","author":"S Piddock","year":"1997","journal-title":"Australian archaeology"},{"issue":"1","key":"pone.0320268.ref155","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1023\/A:1009597226492","article-title":"\u201cAn irregular and inconvenient pile of buildings\u201d: the destitute asylum of Adelaide, South Australia and the English workhouse","volume":"5","author":"S Piddock","year":"2001","journal-title":"Int J Hist Archaeol"},{"issue":"2","key":"pone.0320268.ref156","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/j.1039-8562.2004.02089.x","article-title":"Possibilities and realities: South Australia\u2019s asylums in the 19th century","volume":"12","author":"S Piddock","year":"2004","journal-title":"Australas Psychiatry"},{"key":"pone.0320268.ref157","author":"Destitute Board of South Australia SroSA","year":"2021"},{"key":"pone.0320268.ref158","volume-title":"Lawmakers and wayward whigs: government and law in South Australia, 1836-1986","author":"AC Castles","year":"1987"},{"key":"pone.0320268.ref159","volume-title":"The Flinders history of South Australia. 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Population tables, ages of the people, civil or conjugal relations, birth place, occupation, religion, &c., &c","author":"Government of South Australia","year":"1860"},{"key":"pone.0320268.ref163","first-page":"109","author":"Government of South Australia","year":"1866"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0320268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T17:50:19Z","timestamp":1752774619000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0320268"}},"subtitle":[],"editor":[{"given":"Gwen","family":"Robbins Schug","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":163,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0320268","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]}}}