{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:14:52Z","timestamp":1773116092349,"version":"3.50.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008374","name":"Center for AIDS Research, Emory University","doi-asserted-by":"publisher","award":["P30AI050409"],"award-info":[{"award-number":["P30AI050409"]}],"id":[{"id":"10.13039\/100008374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01NR020437"],"award-info":[{"award-number":["R01NR020437"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["P30MH136919"],"award-info":[{"award-number":["P30MH136919"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec012\">\n<jats:title>Background<\/jats:title>\n<jats:p>There remains limited information concerning US transfeminine persons preferences across varying PrEP options. We examined PrEP option willingness, preferences, and associated factors among a US nationwide sample of transfeminine persons.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec013\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Sexually active transfeminine persons age 15\u2009+ were recruited online between June 2022-October 2023 through social media advertisements. Transfeminine persons not diagnosed with HIV were asked about willingness to initiate, and ranked preference, of three PrEP options\u2013 daily oral (DO), on-demand, and long-acting injectable (LA-PrEP). Log-binomial models were used to examine PrEP modality willingness and associated sociodemographic and behavioral characteristics.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec014\">\n<jats:title>Results<\/jats:title>\n<jats:p>Among 2657 transfeminine persons not currently using PrEP, 51% reported willingness to start at least one PrEP option. The highest willingness was reported for on-demand PrEP (42.6%), followed by DO (38.1%) and LA PrEP (27.1%). LA PrEP was ranked the most preferred PrEP option among transfeminine persons who reported willingness to start multiple PrEP options (43%, 277\/651). Willingness to start on-demand PrEP was higher among participants who were 15-24 years, resided in the South, did not have health insurance, had more than one sex partners and reported prior awareness of on-demand PrEP. Willingness to use DO and LA PrEP was higher among those who had both private and public insurance, reported condomless anal sex, had more than one sex partners and had used non-injection illicit drugs. Additional factors for DO and LA PrEP willingness was residing in the South and prior awareness of LA PrEP, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec015\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Among transfeminine persons, the highest willingness was reported for on-demand PrEP; and LA PrEP was ranked the most preferred option among those who reported willingness to try multiple options. Offering a variety of PrEP options, informed by an understanding of individual preferences and socio-demographic and behavioral differences, can increase overall PrEP uptake and help meet diverse needs of the transfeminine community.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0320961","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T21:14:36Z","timestamp":1743542076000},"page":"e0320961","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preferences and willingness for starting daily, on-demand, and long-acting injectable HIV pre-exposure prophylaxis among transfeminine persons in the US, 2022\u20132023"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-2320","authenticated-orcid":true,"given":"Duygu","family":"Islek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Baral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna A.","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Glick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Friedman","family":"Nestadt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeb","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iaah L.","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemiek","family":"de Ruiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick S","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariah","family":"Valentine-Graves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savannah","family":"Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vani","family":"Vannappagari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"pone.0320961.ref001","author":"Centers for Disease Control and Prevention","year":"2021"},{"key":"pone.0320961.ref002","volume-title":"National HIV\/AIDS Strategy for the United States 2022\u20132025","author":"The White House","year":"2021"},{"issue":"12","key":"pone.0320961.ref003","doi-asserted-by":"crossref","first-page":"e512","DOI":"10.1016\/S2352-3018(15)00206-4","article-title":"HIV pre-exposure prophylaxis in transgender women: a subgroup analysis of the iPrEx trial","volume":"2","author":"MB Deutsch","year":"2015","journal-title":"Lancet HIV"},{"issue":"20","key":"pone.0320961.ref004","doi-asserted-by":"crossref","first-page":"673","DOI":"10.15585\/mmwr.mm7120a1","article-title":"Factors associated with use of HIV prevention and health care among transgender women - seven urban areas, 2019-2020","volume":"71","author":"K Lee","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"pone.0320961.ref005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.15585\/mmwr.su7301a2","article-title":"Characteristics associated with pre-exposure prophylaxis discussion and use among transgender women without HIV infection - national HIV behavioral surveillance among transgender women, seven urban areas, United States, 2019-2020","volume":"73","author":"National HIV Behavioral Surveillance Among Transgender Women Study Group","year":"2024","journal-title":"MMWR Suppl"},{"issue":"12","key":"pone.0320961.ref006","doi-asserted-by":"crossref","first-page":"e26199","DOI":"10.1002\/jia2.26199","article-title":"PrEP initiation and discontinuation among transgender women in the United States: a longitudinal, mixed methods cohort study","volume":"26","author":"EE Cooney","year":"2023","journal-title":"J Int AIDS Soc"},{"issue":"11","key":"pone.0320961.ref007","doi-asserted-by":"crossref","first-page":"e0241340","DOI":"10.1371\/journal.pone.0241340","article-title":"PrEP discontinuation among Latino\/a and Black MSM and transgender women: A need for PrEP support services","volume":"15","author":"O Nieto","year":"2020","journal-title":"PLoS One"},{"key":"pone.0320961.ref008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.annepidem.2022.03.016","article-title":"Prevention-effective adherence trajectories among transgender women indicated for PrEP in the United States: a prospective cohort study","volume":"70","author":"EE Cooney","year":"2022","journal-title":"Ann Epidemiol"},{"issue":"12","key":"pone.0320961.ref009","doi-asserted-by":"crossref","first-page":"e767","DOI":"10.1016\/S2352-3018(23)00261-8","article-title":"Efficacy and safety of long-acting cabotegravir compared with daily oral tenofovir disoproxil fumarate plus emtricitabine to prevent HIV infection in cisgender men and transgender women who have sex with men 1 year after study unblinding: a secondary analysis of the phase 2b and 3 HPTN 083 randomised controlled trial","volume":"10","author":"RJ Landovitz","year":"2023","journal-title":"Lancet HIV"},{"issue":"11","key":"pone.0320961.ref010","doi-asserted-by":"crossref","first-page":"e703","DOI":"10.1016\/S2352-3018(23)00200-X","article-title":"Efficacy, safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir for HIV pre-exposure prophylaxis in transgender women: a secondary analysis of the HPTN 083 trial","volume":"10","author":"MA Marzinke","year":"2023","journal-title":"Lancet HIV"},{"key":"pone.0320961.ref011"},{"issue":"9","key":"pone.0320961.ref012","doi-asserted-by":"crossref","first-page":"e402","DOI":"10.1016\/S2352-3018(17)30089-9","article-title":"Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study","volume":"4","author":"J-M Molina","year":"2017","journal-title":"Lancet HIV"},{"issue":"5","key":"pone.0320961.ref013","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/09564624231152781","article-title":"Barriers to uptake of PrEP across the continuum among transgender women: A global scoping review","volume":"34","author":"F Teng","year":"2023","journal-title":"Int J STD AIDS"},{"issue":"5","key":"pone.0320961.ref014","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/09540121.2019.1659912","article-title":"\u201cSome of us, we don\u2019t know where we\u2019re going to be tomorrow.\u201d Contextual factors affecting PrEP use and adherence among a diverse sample of transgender women in San Francisco","volume":"32","author":"SR Cahill","year":"2020","journal-title":"AIDS Care"},{"issue":"4","key":"pone.0320961.ref015","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s10461-021-03482-8","article-title":"PrEP use and adherence among transgender patients","volume":"26","author":"J Downing","year":"2022","journal-title":"AIDS Behav"},{"issue":"Suppl 3","key":"pone.0320961.ref016","doi-asserted-by":"crossref","first-page":"e25539","DOI":"10.1002\/jia2.25539","article-title":"Disparities in the PrEP continuum for trans women compared to MSM in San Francisco, California: results from population-based cross-sectional behavioural surveillance studies","author":"EC Wilson","year":"2020","journal-title":"J Int AIDS Soc"},{"issue":"5","key":"pone.0320961.ref017","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1089\/trgh.2020.0071","article-title":"Transgender women\u2019s internet survey and testing: protocol and key indicators report","volume":"6","author":"M Zlotorzynska","year":"2021","journal-title":"Transgend Health"},{"issue":"9","key":"pone.0320961.ref018","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1007\/s10461-023-04028-w","article-title":"Intersecting sexual behavior and gender identity stigmas among transgender women in the united states: burden and associations with sexual health","volume":"27","author":"JM Wiginton","year":"2023","journal-title":"AIDS Behav"},{"key":"pone.0320961.ref019","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.annepidem.2020.07.020","article-title":"Gender identity and sexual behavior stigmas, severe psychological distress, and suicidality in an online sample of transgender women in the United States","volume":"52","author":"JL Maksut","year":"2020","journal-title":"Ann Epidemiol"},{"issue":"1","key":"pone.0320961.ref020","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.2196\/publichealth.5476","article-title":"The Annual American Men\u2019s internet survey of behaviors of men who have sex with men in the United States: 2014 key indicators report","volume":"2","author":"T Sanchez","year":"2016","journal-title":"JMIR Public Health Surveill"},{"issue":"166","key":"pone.0320961.ref021","first-page":"1","article-title":"2013 NCHS urban-rural classification scheme for counties","author":"DD Ingram","year":"2014","journal-title":"Vital Health Stat 2"},{"key":"pone.0320961.ref022"},{"issue":"7","key":"pone.0320961.ref023","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1007\/s10461-015-1182-z","article-title":"Correlates of PrEP indication in a multi-site cohort of young HIV-uninfected transgender women","volume":"20","author":"LM Kuhns","year":"2016","journal-title":"AIDS Behav"},{"issue":"2","key":"pone.0320961.ref024","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/QAI.0000000000002112","article-title":"A gap between willingness and uptake: findings from mixed methods research on HIV prevention among black and latina transgender women","volume":"82","author":"T Poteat","year":"2019","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"1","key":"pone.0320961.ref025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.15585\/mmwr.su7301a6","article-title":"Prevalence of discrimination and the association between employment discrimination and health care access and use - National HIV behavioral surveillance among transgender women, seven urban areas, United States, 2019-2020","volume":"73","author":"AR Baugher","year":"2024","journal-title":"MMWR Suppl"},{"issue":"4","key":"pone.0320961.ref026","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s10461-020-03064-0","article-title":"PrEP uptake and discontinuation among a U.S. national sample of transgender men and women","volume":"25","author":"M Zarwell","year":"2021","journal-title":"AIDS Behav"},{"issue":"2","key":"pone.0320961.ref027","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s10461-021-03417-3","article-title":"Improved PrEP awareness and use among trans women in San Francisco, California","volume":"26","author":"EC Wilson","year":"2022","journal-title":"AIDS Behav"},{"key":"pone.0320961.ref028","author":"Centers for Disease Control and Prevention","year":"2021"},{"issue":"3","key":"pone.0320961.ref029","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s10461-010-9795-8","article-title":"Unprotected sexual behavior and HIV risk in the context of primary partnerships for transgender women","volume":"15","author":"D Operario","year":"2011","journal-title":"AIDS Behav"},{"issue":"6","key":"pone.0320961.ref030","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1080\/09540120413331269567","article-title":"Social context of HIV risk behaviours among male-to-female transgenders of colour","volume":"16","author":"T Nemoto","year":"2004","journal-title":"AIDS Care"},{"issue":"7\u20138","key":"pone.0320961.ref031","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1080\/17441692.2016.1154085","article-title":"\u201cI am not a man\u201d: Trans-specific barriers and facilitators to PrEP acceptability among transgender women","volume":"11","author":"JM Sevelius","year":"2016","journal-title":"Glob Public Health"},{"issue":"6","key":"pone.0320961.ref032","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1089\/apc.2021.0236","article-title":"Barriers and facilitators to HIV pre-exposure prophylaxis uptake, adherence, and persistence among transgender populations in the United States: a systematic review","volume":"36","author":"M Dang","year":"2022","journal-title":"AIDS Patient Care STDS"},{"issue":"11","key":"pone.0320961.ref033","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1007\/s10461-018-2102-9","article-title":"Barriers and facilitators to oral PrEP use among transgender women in New York City","volume":"22","author":"CT Rael","year":"2018","journal-title":"AIDS Behav"},{"issue":"1","key":"pone.0320961.ref034","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12889-021-12425-w","article-title":"Exploring barriers and facilitators to PrEP use among transgender women in two urban areas: implications for messaging and communication","volume":"22","author":"SB Bass","year":"2022","journal-title":"BMC Public Health"},{"issue":"7","key":"pone.0320961.ref035","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s10461-021-03159-2","article-title":"Multilevel Barriers to HIV PrEP Uptake and Adherence Among Black and Hispanic\/Latinx Transgender Women in Southern California","volume":"25","author":"A Ogunbajo","year":"2021","journal-title":"AIDS Behav"},{"issue":"1","key":"pone.0320961.ref036","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1186\/s12879-024-09456-0","article-title":"Perceived risk for HIV acquisition and sexual HIV exposure among sexual and gender minorities: a systematic review","volume":"24","author":"H Vega-Ramirez","year":"2024","journal-title":"BMC Infect Dis"},{"issue":"4","key":"pone.0320961.ref037","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3758\/s13428-014-0533-4","article-title":"Disclosure of sensitive behaviors across self-administered survey modes: a meta-analysis","volume":"47","author":"T Gnambs","year":"2015","journal-title":"Behav Res Methods"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0320961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T21:15:32Z","timestamp":1743542132000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0320961"}},"subtitle":[],"editor":[{"given":"Adedotun","family":"Ogunbajo","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0320961","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]}}}