{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:59:15Z","timestamp":1780567155237,"version":"3.54.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nBackground<\/jats:title>\nPharmacological advances have improved pediatric dilated cardiomyopathy (DCM) prognosis, which manifests as left ventricular reverse remodeling (LVRR). However, significant inter-individual variability exists in therapeutic response. Identifying predictors is critical for individualizing management to inform device and transplant timing.<\/jats:p>\n<\/jats:sec>\n\nAim<\/jats:title>\nTo develop a nomogram for predicting LVRR in pediatric DCM.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nA retrospective analysis of 146 children hospitalized for DCM from January 2012 to June 2023. 55 exhibited LVRR. A nomogram predicting pediatric DCM-LVRR was developed using univariate analysis and logistic regression to select predictors. The nomogram was validated via bootstrapping and receiver operating characteristic curves for discrimination. Calibration was assessed with the Hosmer-Lemeshow test. Decision curve analysis evaluated performance and utility.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nAge, left ventricular end-diastolic dimension Z-score, and QRS interval were associated with the occurrence of LVRR. Discrimination was high (C-index 0.903) and internally validated on bootstrapping with 1000 repetitions (Adjusted C-index 0.895). The Hosmer-Lemeshow test revealed no significant deviation between nomogram predictions and outcomes (\u03c72 =\u2009 10.883; P =\u2009 0.207). DCA revealed that the model was clinically useful at threshold probabilities >\u20094%.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nWe developed and internally validated a nomogram predicting LVRR for pediatric DCM patients, exhibiting high sensitivity, specificity and clinical utility.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0321126","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T21:28:39Z","timestamp":1743542919000},"page":"e0321126","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["A predictive model for left ventricular reverse remodeling after pharmacological therapy in children with recent-onset dilated cardiomyopathy"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1194-5340","authenticated-orcid":true,"given":"Yong","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-1664","authenticated-orcid":true,"given":"Yusheng","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"issue":"5","key":"pone.0321126.ref001","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.CIR.93.5.841","article-title":"Report of the 1995 World Health Organization\/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies","volume":"93","author":"P Richardson","year":"1996","journal-title":"Circulation"},{"issue":"7","key":"pone.0321126.ref002","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.healun.2015.01.980","article-title":"Management of children with dilated cardiomyopathy in The Netherlands: Implications of a low early transplantation rate","volume":"34","author":"SL den Boer","year":"2015","journal-title":"J Heart Lung Transplant"},{"issue":"18","key":"pone.0321126.ref003","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1161\/CIRCULATIONAHA.113.002767","article-title":"Long-term outcomes of dilated cardiomyopathy diagnosed during childhood: results from a national population-based study of childhood cardiomyopathy","volume":"128","author":"PMA Alexander","year":"2013","journal-title":"Circulation"},{"issue":"2","key":"pone.0321126.ref004","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ehf2.12082","article-title":"Heart failure from heart muscle disease in childhood: a 5-10 year follow-up study in the UK and Ireland","volume":"3","author":"RE Andrews","year":"2016","journal-title":"ESC Heart Fail"},{"issue":"4","key":"pone.0321126.ref005","first-page":"253","article-title":"How the natural history of dilated cardiomyopathy has changed. 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