{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:16:49Z","timestamp":1788999409712,"version":"build-2803163510"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This study explored the patterns of comorbidities and their impact on health-related quality of life (HRQoL) among elderly individuals living in rural communities in Vietnam. A cross-sectional study was conducted across four communes in Thai Binh province. The demographic characteristics and comorbidities of the participants were evaluated, along with their Euroqol-5 dimensions-5 levels (EQ-5D-5L), using a structured questionnaire supplemented by clinical examinations. A multivariate Tobit regression model was applied to assess the relationship between comorbidities and HRQoL. Results showed that a minority of participants (9.5%) were free of comorbidities. Cataracts were the most common condition (61.0%), followed by osteoarthritis (55.4%), rheumatoid arthritis (46.1%), and dementia (39.0%). The average EQ-5D index was 0.806 (SD =\u2009 0.184). Pain\/discomfort, difficulties with usual activities, and anxiety\/depression contributed most to the reduction in the EQ-5D-5L index. Participants with rheumatoid arthritis (\u03b2 =\u2009 \u2212\u20090.10; 95% CI =\u2009 \u2212\u20090.13, \u2212\u20090.07) and postural hypotension (\u03b2 =\u2009 \u2212\u20090.08; 95% CI =\u2009 \u2212\u20090.14, \u2212\u20090.02) experienced the greatest decrease in EQ-5D index, followed by those with urinary diseases (\u03b2 =\u2009 \u2212\u20090.05; 95% CI =\u2009 \u2212\u20090.09, \u2212\u20090.02) and stroke (\u03b2 =\u2009 \u2212\u20090.05; 95% CI =\u2009 \u2212\u20090.09, \u2212\u20090.01). This study highlights the high prevalence of comorbidities among the elderly in rural Vietnam, with arthritis, postural hypotension, urinary diseases, and stroke being most strongly associated with reduced HRQoL. Regular screening and monitoring of comorbidities are vital to identify individuals who would benefit most from healthcare interventions to enhance HRQoL.<\/jats:p>","DOI":"10.1371\/journal.pone.0321267","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T23:20:24Z","timestamp":1743636024000},"page":"e0321267","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comorbidities and health-related quality of life among rural older community-dwellers in Vietnam"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3350-3432","authenticated-orcid":true,"given":"Hai Minh","family":"Vu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao Thi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu","family":"Minh Hai (B)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuong Duy","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My Ha","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanh Thi Kieu","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dat Cong","family":"Truong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien Xuan","family":"Luong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"pone.0321267.ref001","volume-title":"Ageing and health: Fact sheets","author":"Organization WH","year":"2022"},{"key":"pone.0321267.ref002","volume-title":"World Social Report 2023: Leaving no one behind in an ageing world. 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Int"},{"issue":"3","key":"pone.0321267.ref009","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/JETS.JETS_62_16","article-title":"Older Age, comorbid illnesses, and injury severity affect immediate outcome in elderly trauma patients","volume":"10","author":"D Kirshenbom","year":"2017","journal-title":"J Emerg Trauma Shock"},{"key":"pone.0321267.ref010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2318-11-45","article-title":"Patterns of comorbidity in community-dwelling older people hospitalised for fall-related injury: a cluster analysis","volume":"11","author":"T Vu","year":"2011","journal-title":"BMC Geriatr"},{"key":"pone.0321267.ref011","first-page":"863473","article-title":"Prevalence and determinants of fall-related injuries among older adults in ecuador","author":"CH Orces","year":"2014","journal-title":"Curr Gerontol Geriatr Res"},{"key":"pone.0321267.ref012","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.archger.2017.08.008","article-title":"The elderly and falls: factors associated with quality of life A cross-sectional study using large-scale national data in Korea","volume":"73","author":"J-W Noh","year":"2017","journal-title":"Arch Gerontol Geriatr"},{"issue":"20","key":"pone.0321267.ref013","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1001\/archinte.162.20.2269","article-title":"Prevalence, expenditures, and complications of multiple chronic conditions in the elderly","volume":"162","author":"JL Wolff","year":"2002","journal-title":"Arch Intern Med"},{"issue":"9836","key":"pone.0321267.ref014","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0140-6736(12)60240-2","article-title":"Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study","volume":"380","author":"K Barnett","year":"2012","journal-title":"Lancet"},{"key":"pone.0321267.ref015","first-page":"i4843","article-title":"Clinical assessment and management of multimorbidity: summary of NICE guidance","volume":"354","author":"C Farmer","year":"2016"},{"issue":"2","key":"pone.0321267.ref016","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s40258-017-0310-5","article-title":"EQ-5D and the EuroQol Group: past, present and future","volume":"15","author":"NJ Devlin","year":"2017","journal-title":"Appl Health Econ Health Policy"},{"key":"pone.0321267.ref017","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12955-015-0372-8","article-title":"A systematic review of instruments for measuring outcomes in economic evaluation within aged care","volume":"13","author":"NB Bulamu","year":"2015","journal-title":"Health Qual Life 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V.","year":"2020"},{"key":"pone.0321267.ref022","volume-title":"Older Adults in Vietnam: An Analysis of the Population Change and Family Planning Survey 2021","author":"Japan Fund for Poverty R.","year":"2021"},{"issue":"7","key":"pone.0321267.ref023","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1017\/S1041610213000458","article-title":"Comorbidity, healthstatus, and quality of life in institutionalized older people with and without dementia","volume":"25","author":"S Mart\u00edn-Garc\u00eda","year":"2013","journal-title":"Int Psychogeriatr"},{"key":"pone.0321267.ref024","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1477-7525-9-53","article-title":"Multimorbidity and health-related quality of life in the older population: results from the German KORA-age study","volume":"9","author":"M Hunger","year":"2011","journal-title":"Health Qual Life 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Valuing health - related quality of life: an EQ-5D-5L value set for Vietnam. 2018."},{"issue":"1","key":"pone.0321267.ref028","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12955-017-0771-0","article-title":"Quality of life profile of general Vietnamese population using EQ-5D-5L","volume":"15","author":"LH Nguyen","year":"2017","journal-title":"Health Qual Life Outcomes"},{"key":"pone.0321267.ref029","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12955-016-0485-8","article-title":"Health status and health service utilization in remote and mountainous areas in Vietnam","volume":"14","author":"BX Tran","year":"2016","journal-title":"Health Qual Life Outcomes"},{"key":"pone.0321267.ref030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1477-7525-10-132","article-title":"Quality of life profile and psychometric properties of the EQ-5D-5L in HIV\/AIDS patients","volume":"10","author":"BX Tran","year":"2012","journal-title":"Health Qual 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Vietnam","volume":"8","author":"CQ Ngo","year":"2019","journal-title":"J Clin Med"},{"issue":"1","key":"pone.0321267.ref034","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/17457300701800118","article-title":"Mortality in elderly injured patients: the role of comorbidities","volume":"15","author":"L Camilloni","year":"2008","journal-title":"Int J Inj Contr Saf Promot"},{"issue":"12","key":"pone.0321267.ref035","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1111\/j.1532-5415.2004.52560.x","article-title":"Epidemiology and short-term outcomes of injured medicare patients","volume":"52","author":"DE Clark","year":"2004","journal-title":"J Am Geriatr Soc"},{"issue":"9","key":"pone.0321267.ref036","doi-asserted-by":"crossref","first-page":"e0138521","DOI":"10.1371\/journal.pone.0138521","article-title":"Prevalence and patterns of chronic disease pairs and multimorbidity among older Chinese adults living in a rural area","volume":"10","author":"R Wang","year":"2015","journal-title":"PLoS One"},{"key":"pone.0321267.ref037","doi-asserted-by":"crossref","first-page":"1186248","DOI":"10.3389\/fpubh.2023.1186248","article-title":"Identification of status quo and association rules for chronic comorbidity among Chinese middle-aged and older adults rural residents","volume":"11","author":"Z Yu","year":"2023","journal-title":"Front Public Health"},{"issue":"8","key":"pone.0321267.ref038","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.18203\/2394-6040.ijcmph20183073","article-title":"Hypertension and other morbidities among a rural geriatric population of North Kerala","volume":"5","author":"SR Jacob","year":"2018","journal-title":"Int J Community Med Public Health"},{"issue":"4","key":"pone.0321267.ref039","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/ijerph16040531","article-title":"Impact of comorbid chronic conditions to quality of life among elderly patients with diabetes mellitus in Vietnam","volume":"16","author":"HV Nguyen","year":"2019","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"pone.0321267.ref040","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00277-015-2541-6","article-title":"The impact of comorbidity on health-related quality of life in elderly patients with chronic myeloid leukemia","volume":"95","author":"F Efficace","year":"2016","journal-title":"Ann Hematol"},{"issue":"3","key":"pone.0321267.ref041","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/ageing\/afy155","article-title":"The impact of co-morbidity on the quality of life of people with dementia: findings from the IDEAL study","volume":"48","author":"SM Nelis","year":"2019","journal-title":"Age Ageing"},{"issue":"12","key":"pone.0321267.ref042","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1007\/s11136-023-03489-9","article-title":"Health-related quality of life and associated factors in elderly individuals with 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