{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:11:07Z","timestamp":1787325067007,"version":"build-2736575974"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec016\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The predictive value of serum uric acid (SUA) for clinical outcomes in patients with sepsis-associated acute kidney injury (SA-AKI) remained unclear. Therefore, this study aimed to evaluate the clinical significance of SUA in predicting all-cause mortality among critically ill patients diagnosed with SA-AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec017\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study examined 483 patients with SA-AKI at the Affiliated Hospital of Jiangsu University from January 2015 to July 2023. The primary outcome evaluated in this study was in hospital all-cause mortality. To assess the prognostic value of SUA, we employed receiver operating characteristic curves, restricted cubic splines, Cox regression models, and Kaplan-Meier survival analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec018\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The hospital mortality and intensive care unit (ICU) mortality reached 43.3% and 42.2%, respectively. Kaplan-Meier analysis showed that the risk of 30-day mortality (log-rank test, P\u2009&lt;\u20090.001) and 60-day mortality (log-rank test, P\u2009=\u20090.001) was significantly higher in patients with hyperuricemia (HUA). Multivariate Cox proportional hazards analysis showed that elevated SUA levels were significantly related to all-cause mortality. After accounting for potential confounding factors, patients with HUA maintained a significant correlation with both hospital mortality [HR (95%CI): 1.462 (1.094-1.952); P\u2009=\u20090.010] and ICU mortality [HR (95%CI): 1.474 (1.096-1.983); P\u2009=\u20090.010]. Further examination using restricted cubic splines revealed a progressively increasing risk of all-cause mortality with rising SUA levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec019\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher levels of SUA were associated with an increased risk of both hospital mortality and ICU mortality in critically ill patients with SA-AKI. These findings suggested that SUA may serve as an independent prognostic marker for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0321576","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T13:29:44Z","timestamp":1746624584000},"page":"e0321576","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum uric acid level as a prognostic biomarker in critically ill patients with sepsis-associated acute kidney injury: A retrospective single-center study"],"prefix":"10.1371","volume":"20","author":[{"given":"Zhenkui","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-2752","authenticated-orcid":true,"given":"Jinhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"issue":"9887","key":"pone.0321576.ref001","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(13)60647-9","article-title":"Acute kidney injury: an increasing global concern","volume":"382","author":"NH Lameire","year":"2013","journal-title":"Lancet"},{"issue":"1","key":"pone.0321576.ref002","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semnephrol.2015.01.002","article-title":"Sepsis-associated acute kidney injury","volume":"35","author":"R Alobaidi","year":"2015","journal-title":"Semin Nephrol"},{"issue":"3","key":"pone.0321576.ref003","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1053\/j.ajkd.2019.10.010","article-title":"Critical Care Nephrology: Core Curriculum 2020","volume":"75","author":"BR Griffin","year":"2020","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"pone.0321576.ref004","doi-asserted-by":"crossref","first-page":"859","DOI":"10.33549\/physiolres.931936","article-title":"New developments in septic acute kidney injury","volume":"59","author":"J Chvojka","year":"2010","journal-title":"Physiol Res"},{"issue":"4","key":"pone.0321576.ref005","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/01.ASN.0000059863.48590.E9","article-title":"Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome","volume":"14","author":"EAJ Hoste","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"pone.0321576.ref006","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/oxfordjournals.ndt.a027256","article-title":"Prognostic factors in acute renal failure due to sepsis. 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