{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:35:59Z","timestamp":1776980159203,"version":"3.51.4"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nBackground<\/jats:title>\nBreast cancer poses a significant health challenge in Pakistan, with a disproportionately high number of cases diagnosed at advanced stages. Despite the rising incidence, preventative measures like regular screening remain not commonly practiced among Pakistani women. While extensive research exists on breast cancer globally, there is a critical gap in studies specifically designed and evaluated to enhance breast self-examination practices within the Pakistani context.<\/jats:p>\n<\/jats:sec>\n\nMethodology<\/jats:title>\nThe primary goal of this study is to design and implement an educational intervention on breast self-examination and evaluate its effectiveness among college teachers in Pakistan. This protocol outlines a single-blind, parallel cluster randomized controlled trial (CRCT) with an intervention period of three months. Clusters will be randomly assigned to either the control or intervention groups,and baseline data will be gathered from both groups. An intervention based on the health belief model will be executed for the intervention group to improve women\u2019s knowledge and behaviors about breast self-examination (BSE). Data will be collected at two follow-up intervals for both groups post-intervention. The modified questionnaires include constructs such as breast cancer symptoms, risk factors, detection techniques, frequency and practices of breast self-examination, and perceptions of breast cancer. The control group will get the intervention once the trial concludes. The primary outcome of this study is breast self-examination (BSE) practice, whereas secondary outcomes encompass knowledge and beliefs related to breast cancer and BSE.<\/jats:p>\n<\/jats:sec>\n\nDiscussion<\/jats:title>\nThis cluster randomized controlled trial is aimed to improve the efficacy and legitimacy of theory-based intervention by increasing women\u2019s knowledge of breast self-examination and breast cancer and changing their attitudes to encourage early breast cancer detection by practicing breast self-examination. This might significantly allow an improved detection rate; therefore, earlier treatment can be offered. Therefore, lower the death rate from breast cancer and guide health promotion initiatives in other comparable settings. Furthermore, less aggressive therapies are frequently possible with early detection, which enhances healthcare cost-effectiveness while also improving patient outcomes and treatment burdens.<\/jats:p>\n<\/jats:sec>\n\nTrial registration<\/jats:title>\nThis study protocol is registered with the Thai Clinical Trial Registry (TCTR), TCTR20240703005<\/jats:ext-link> (https:\/\/www.thaiclinicaltrials.org\/show\/TCTR20240703005<\/jats:underline><\/jats:ext-link>). The following study protocol complied with the Standard Protocol Items Recommendations for Interventional Trials (SPIRIT) checklist. 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