{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:08:33Z","timestamp":1782425313527,"version":"3.54.5"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Skin lesions, including various abnormalities and potentially fatal skin cancers, require early detection for effective treatment. However, current methods often struggle to identify the precise areas responsible for these abnormalities after model dominance dispersion. To address this, we propose a novel Transfer Learning-based framework that integrates Optimized RegNet Synergy architectures and Attention-Triplet mechanisms\u2014comprising channel attention, squeeze-excitation attention, and soft attention\u2014combined with an advanced Ensemble Learning strategy. A significant gap in current research is the lack of techniques for optimal weight allocation in model predictions. Our study fills this gap by introducing the <jats:inline-formula id=\"pone.0321803.e001\"><jats:alternatives><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"pone.0321803.e001g\" mimetype=\"image\" position=\"anchor\" xlink:href=\"info:doi\/10.1371\/journal.pone.0321803.e001\" xlink:type=\"simple\"\/><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" id=\"M1\"><mml:mrow><mml:msup><mml:mtext mathvariant=\"italic\">Chi<\/mml:mtext><mml:mn>2<\/mml:mn><\/mml:msup><\/mml:mrow><\/mml:math><\/jats:alternatives><\/jats:inline-formula> Weighted Ensemble (CWE) method, which is further enhanced into a Multi-Layer <jats:inline-formula id=\"pone.0321803.e002\"><jats:alternatives><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"pone.0321803.e002g\" mimetype=\"image\" position=\"anchor\" xlink:href=\"info:doi\/10.1371\/journal.pone.0321803.e002\" xlink:type=\"simple\"\/><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" id=\"M2\"><mml:mrow><mml:msup><mml:mtext mathvariant=\"italic\">Chi<\/mml:mtext><mml:mn>2<\/mml:mn><\/mml:msup><\/mml:mrow><\/mml:math><\/jats:alternatives><\/jats:inline-formula> Weighted Ensemble (ML-CWE) to improve model aggregation across multiple layers. Evaluation on the HAM1000 dataset demonstrates that our ML-CWE approach achieves an impressive accuracy of 94.08%, outperforming existing state-of-the-art methods. To enhance model interpretability, we employ Gradient Class Activation Maps (Grad-CAM) to highlight critical regions of interest, improving both transparency and reliability. This work not only boosts accuracy but also facilitates early diagnosis, addressing challenges related to time, accessibility, and cost in skin lesion detection, and offering valuable insights for practical applications in dermatology.<\/jats:p>","DOI":"10.1371\/journal.pone.0321803","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T17:24:08Z","timestamp":1747761848000},"page":"e0321803","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Chi2 weighted ensemble: A multi-layer ensemble approach for skin lesion classification using a novel framework - optimized RegNet synergy with Attention-Triplet"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7999-1512","authenticated-orcid":true,"given":"Anwar Hossain","family":"Efat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"issue":"19","key":"pone.0321803.ref001","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.3390\/diagnostics13193063","article-title":"MSRNet: Multiclass skin lesion recognition using additional residual block based fine-tuned deep models information fusion and best feature selection","volume":"13","author":"S Bibi","year":"2023","journal-title":"Diagnostics"},{"key":"pone.0321803.ref002","doi-asserted-by":"crossref","unstructured":"Dillshad V, Khan M, Nazir M, Saidani O, Alturki N, Kadry S. 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