{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:57:06Z","timestamp":1772503026783,"version":"3.50.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Periodontitis is considered an inflammatory disease that affects the tooth\u2019s supporting structures, resulting in its progressive destruction, which can lead to several problems, such as loss of teeth, bone reabsorption, and even exacerbation of chronic systemic diseases. Periodontitis is a common periodontal condition in the adult dentate population, affecting approximately 6 in 10 individuals. Among those affected, approximately 25% develop the most severe form of the disease. The prevalence of periodontitis in adolescents is not well established. Therefore, this study protocol of a systematic review that aims to answer the following research question: \u201cWhat is the prevalence of periodontitis in adolescents?\u201d. This systematic review will include observational studies reporting the prevalence of periodontitis in individuals aged from 13 to 18 years without comorbidities. A search will be conducted in the following databases: EMBASE, LILACS (via BVS), MEDLINE (via PubMed), and Web of Science. The gray literature will be consulted through Google Scholar and ProQuest. No language or time of publication restrictions will be applied. To determine which studies will be included, two independent reviewers will select the articles through a two-phase process. In the first phase, reviewers will assess the titles and abstracts, and, in the second phase, they will read the full texts using predefined eligibility criteria. Data collected will include author, study design, year of publication, country, sample size, sex, age, diagnostic methods, definition of periodontitis, reliability of criteria, examination protocol, case classification and prevalence rates. The risk of bias will be assessed according to the JBI Critical Appraisal Checklist for Studies Reporting Prevalence Data. Results will be synthesized into a narrative description and, if possible, a meta-analysis will be conducted. The systematic review methodology will enable a comprehensive and accurate analysis of the available evidence. Moreover, this approach may contribute to clinical decision-making, promoting the use of more appropriate and preventive treatments.<\/jats:p>","DOI":"10.1371\/journal.pone.0321993","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T17:48:04Z","timestamp":1746467284000},"page":"e0321993","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of periodontitis in adolescents: A systematic review protocol"],"prefix":"10.1371","volume":"20","author":[{"given":"Ana Beatriz","family":"de Oliveira Monteiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia Rosana","family":"Honnef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia Meller","family":"Dias de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1762-7059","authenticated-orcid":true,"given":"Patr\u00edcia","family":"Pauletto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Massignan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristine Miron","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-8994","authenticated-orcid":true,"given":"Glaucia Santos","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziela De Luca","family":"Canto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"pone.0321993.ref001","first-page":"S173","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-Implant diseases and conditions","volume":"89 Suppl 1","author":"PN Papapanou","year":"2018","journal-title":"J Periodontol"},{"issue":"6","key":"pone.0321993.ref002","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"T Kwon","year":"2021","journal-title":"Int Dent J"},{"key":"pone.0321993.ref003","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0757.1998.tb00113.x","article-title":"Epidemiology of periodontal disease among older adults: a review","volume":"16","author":"D Locker","year":"1998","journal-title":"Periodontol 2000"},{"issue":"10","key":"pone.0321993.ref004","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/JPER.21-0469","article-title":"Global, regional, and national burden of periodontitis from 1990 to 2019: results from the global burden of Disease study 2019","volume":"93","author":"L Wu","year":"2022","journal-title":"J Periodontol"},{"issue":"5","key":"pone.0321993.ref005","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/jre.13337","article-title":"Burden of severe periodontitis and edentulism in 2021, with projections up to 2050: the global burden of Disease 2021 study","volume":"59","author":"GG Nascimento","year":"2024","journal-title":"J Periodontal Res"},{"issue":"6","key":"pone.0321993.ref006","doi-asserted-by":"crossref","first-page":"784","DOI":"10.4103\/0972-124X.124507","article-title":"Prevalence of periodontitis among the adolescents aged 15-18 years in Mangalore City: an epidemiological and microbiological study","volume":"17","author":"KP Nanaiah","year":"2013","journal-title":"J Indian Soc Periodontol"},{"issue":"1","key":"pone.0321993.ref007","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s10266-023-00817-w","article-title":"Periodontal diseases in Thai schoolchildren. Clinical and microbiological observations","volume":"112","author":"S Piwat","year":"2024","journal-title":"Odontology"},{"key":"pone.0321993.ref008","doi-asserted-by":"crossref","first-page":"2146160","DOI":"10.1155\/2020\/2146160","article-title":"Global prevalence of periodontal disease and lack of its surveillance","volume":"2020","author":"M Nazir","year":"2020","journal-title":"Scientificworldjournal"},{"issue":"20","key":"pone.0321993.ref009","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12206442","article-title":"Factors associated with periodontitis in younger individuals: a scoping review","volume":"12","author":"M Hung","year":"2023","journal-title":"J Clin Med"},{"issue":"3","key":"pone.0321993.ref010","first-page":"195","article-title":"Prevalence of periodontitis in young populations: a systematic review","volume":"17","author":"RQ Catunda","year":"2019","journal-title":"Oral Health Prev Dent"},{"key":"pone.0321993.ref011","author":"Research NIFHAC","year":"2023"},{"key":"pone.0321993.ref012","first-page":"175","article-title":"Systematic reviews of prevalence and incidence.","volume-title":"JBI manual for evidence synthesis","author":"Z Munn","year":"2020"},{"key":"pone.0321993.ref013","volume-title":"Risco de vi\u00e9s em revis\u00f5es sistem\u00e1ticas: guia Pr\u00e1tico","author":"G De Luca Canto","year":"2021"},{"key":"pone.0321993.ref014","first-page":"1","article-title":"Risk-of-bias visualization (robvis): an r package and shiny web app for visualizing risk-of-bias assessments","author":"LA McGuinness","year":"2020","journal-title":"Res syn meth"},{"key":"pone.0321993.ref015","volume-title":"Handbook of epidemiology","author":"W Ahrens","year":"2013"},{"issue":"5","key":"pone.0321993.ref016","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3758\/s13428-020-01373-9","article-title":"The application of meta-analytic (multi-level) models with multiple random effects: a systematic review","volume":"52","author":"B Fern\u00e1ndez-Castilla","year":"2020","journal-title":"Behav Res Methods"},{"issue":"5","key":"pone.0321993.ref017","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/jcpe.12392","article-title":"Standards for reporting chronic periodontitis prevalence and severity in epidemiologic studies: proposed standards from the Joint EU\/USA Periodontal Epidemiology Working Group","volume":"42","author":"B Holtfreter","year":"2015","journal-title":"J Clin Periodontol"},{"issue":"1","key":"pone.0321993.ref018","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/cvr\/cvz201","article-title":"Periodontitis is associated with hypertension: a systematic review and meta-analysis","volume":"116","author":"E Mu\u00f1oz Aguilera","year":"2020","journal-title":"Cardiovasc Res"},{"key":"pone.0321993.ref019","first-page":"S159","article-title":"Staging and grading of periodontitis: framework and proposal of a new classification and case definition","volume":"89 Suppl 1","author":"MS Tonetti","year":"2018","journal-title":"J Periodontol"},{"issue":"5","key":"pone.0321993.ref020","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1902\/jop.2015.140520","article-title":"Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012","volume":"86","author":"PI Eke","year":"2015","journal-title":"J periodontol"},{"key":"pone.0321993.ref021","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1902\/jop.2007.060264","article-title":"Case definitions for use in population-based surveillance of periodontitis","volume":"78","author":"RC Page","year":"2007","journal-title":"J Periodontol"},{"issue":"11","key":"pone.0321993.ref022","first-page":"594","article-title":"The periodontal disease classification system of the American Academy of Periodontology--an update","volume":"66","author":"CB Wiebe","year":"2000","journal-title":"J Can Dent Assoc"},{"issue":"1","key":"pone.0321993.ref023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"GC Armitage","year":"1999","journal-title":"Ann Periodontol"},{"key":"pone.0321993.ref024","first-page":"97","article-title":"Condi\u00e7\u00f5es periodontais.","volume-title":"Epidemiologia da sa\u00fade bucal","author":"MV Vettore","year":"2013"},{"issue":"7109","key":"pone.0321993.ref025","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"BMJ"},{"key":"pone.0321993.ref026","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jclinepi.2023.05.010","article-title":"The development methods of official GRADE articles and requirements for claiming the use of GRADE - a statement by the GRADE guidance group","volume":"159","author":"HJ Sch\u00fcnemann","year":"2023","journal-title":"J Clin Epidemiol"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0321993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T17:48:14Z","timestamp":1746467294000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0321993"}},"subtitle":[],"editor":[{"given":"Andrej M","family":"Kielbassa","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,5,5]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0321993","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,5]]}}}