{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:51:21Z","timestamp":1789051881301,"version":"build-2803163510"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Developing Center of Shenkang Hospital","award":["SHDC22020209"],"award-info":[{"award-number":["SHDC22020209"]}]},{"name":"Shanghai Municipal Key Clinical Specialty","award":["shslczdzk06302"],"award-info":[{"award-number":["shslczdzk06302"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Genetic testing is widely recommended in the diagnosis and management of breast cancer. This study aimed to investigate the knowledge, attitude, and practice (KAP) toward genetic testing in Chinese patients with breast cancer. This multicenter cross-sectional study enrolled breast cancer patients in seven public hospitals in Shanghai, China, between November 2022 and January 2023. A self-administered web-based questionnaire was used to collect the participants\u2019 demographic information and their KAP regarding genetic testing. A total of 592 valid questionnaires were collected in this study; 145 (24.49%) patients underwent genetic testing, and 20.61% of the patients never learned about genetic testing. The knowledge, attitude, and practice scores were 4.59\u2009\u00b1\u20094.49 (22.95%, possible range: 0\u201320), 16.72\u2009\u00b1\u20092.92 (83.60%, possible range: 0\u201320), and 23.67\u2009\u00b1\u20095.18 (73.97%, possible range: 0\u201332), respectively. Multivariable logistic regression showed that knowledge (OR\u2009=\u20091.21, 95%CI: 1.51\u20131.28, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), attitude (OR\u2009=\u20091.10, 95%CI: 1.01\u20131.19, <jats:italic>P<\/jats:italic>\u2009=\u20090.027), Jiangsu Province (OR\u2009=\u20090.40, 95%CI: 0.19\u20130.84, <jats:italic>P<\/jats:italic>\u2009=\u20090.016), monthly income of 5000\u201310,000 CNY (OR\u2009=\u20090.46, 95%CI: 0.25\u20130.86, <jats:italic>P<\/jats:italic>\u2009=\u20090.015), disease duration of 5\u201310 years (OR\u2009=\u20090.50, 95%CI: 0.27\u20130.94, <jats:italic>P<\/jats:italic>\u2009=\u20090.030) and disease duration of\u2009\u2265\u200910 years (OR\u2009=\u20090.26, 95%CI: 0.11\u20130.60, <jats:italic>P<\/jats:italic>\u2009=\u20090.002), triple-negative subtype (OR\u2009=\u20093.45, 95%CI: 1.51\u20137.85, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) were independently associated with patients\u2019 behavior of undergoing genetic testing. The structural equation modeling showed that knowledge directly positively influenced attitude (\u03b2\u2009=\u20090.343, P\u2009&lt;\u20090.001), while attitude directly positively influenced practice (\u03b2\u2009=\u20090.942, P\u2009&lt;\u20090.001). Chinese patients with breast cancer demonstrated poor knowledge, positive attitude, and suboptimal practice toward genetic testing. More education and counseling on genetic testing for patients are necessary.<\/jats:p>","DOI":"10.1371\/journal.pone.0322526","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T17:27:38Z","timestamp":1746725258000},"page":"e0322526","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Knowledge, attitude, and practice toward genetic testing in breast cancer patients in China"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-345X","authenticated-orcid":true,"given":"Xin","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"issue":"3","key":"pone.0322526.ref001","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"pone.0322526.ref002","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/cac2.12207","article-title":"Global patterns of breast cancer incidence and mortality: a population-based cancer registry data analysis from 2000 to 2020","volume":"41","author":"S Lei","year":"2021","journal-title":"Cancer Commun (Lond)"},{"key":"pone.0322526.ref003","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.7150\/ijbs.60631","article-title":"Progress of breast cancer basic research in China","volume":"17","author":"X Wang","year":"2021","journal-title":"Int J Biol Sci"},{"key":"pone.0322526.ref004","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1016\/S0140-6736(21)00684-X","article-title":"The lancet women and cardiovascular disease commission: reducing the global burden by 2030","volume":"397","author":"B Vogel","year":"2021","journal-title":"Lancet"},{"key":"pone.0322526.ref005","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1200\/JCO.21.01426","article-title":"Genetic counseling and testing in African American patients with breast cancer: a nationwide survey of US breast oncologists","volume":"39","author":"FO Ademuyiwa","year":"2021","journal-title":"J Clin Oncol"},{"key":"pone.0322526.ref006","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s10897-017-0194-4","article-title":"Breast cancer genetics knowledge and testing intentions among Nigerian professional women","volume":"27","author":"SO Ngene","year":"2018","journal-title":"J Genet Couns"},{"key":"pone.0322526.ref007","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41586-019-1382-1","article-title":"Tumour lineage shapes BRCA-mediated phenotypes","volume":"571","author":"P Jonsson","year":"2019","journal-title":"Nature"},{"key":"pone.0322526.ref008","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1056\/NEJMoa1913948","article-title":"Breast cancer risk genes \u2013 association analysis in more than 113,000 women","volume":"384","author":"L Dorling","year":"2021","journal-title":"N Engl J Med"},{"key":"pone.0322526.ref009","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/s41467-022-29335-z","article-title":"Modification of BRCA1-associated breast cancer risk by HMMR overexpression","volume":"13","author":"F Mateo","year":"2022","journal-title":"Nat Commun"},{"key":"pone.0322526.ref010","article-title":"Genetic\/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic. 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