{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:11:38Z","timestamp":1750219898188,"version":"3.41.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Projects of the State Key Laboratory of Radiation Medicine and Radiation Protection","award":["GZK12023015"],"award-info":[{"award-number":["GZK12023015"]}]},{"name":"Suzhou Basic Research Program-Medical Application Basic Research- New Diagnosis and Treatment Technology Research","award":["SKY2023073"],"award-info":[{"award-number":["SKY2023073"]}]},{"name":"Jiangsu Provincial Department of Science and Technology- Key Research and Development Program Social Development","award":["BE2023718"],"award-info":[{"award-number":["BE2023718"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec019\">\n<jats:title>Objective<\/jats:title>\n<jats:p>China is a country with a high burden of tuberculosis (TB). It is vital to reduce the number of new cases of TB in China. We aimed to examine and investigate the distribution and affecting factors of the latent tuberculosis infection (LTBI) detection rate in hospitalized patients in Suzhou, Jiangsu Province.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec020\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We analyzed the link between LTBI and patients\u2019 information, disease diagnosis, and blood routine indices of hospitalized patients at the Fifth People\u2019s Hospital in Suzhou from January 1, 2018, to March 31, 2024.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec021\">\n<jats:title>Results<\/jats:title>\n<jats:p>Results indicated that of the 6692 patients included in the study, 39.05% of them were diagnosed with LTBI. Multivariate analysis revealed that sex, AIDS status, testing time, age, lymphocyte count, and neutrophil count were influencing factors for the detection of LTBI (\u2009p &lt;\u20090.05). However, hepatitis B, diabetes, hypertension, silicosis and monocyte count did not significantly influence LTBI detection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec022\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Sex, AIDS status, testing time, age, lymphocyte count, and neutrophil count were influencing factors for the detection of LTBI.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0322913","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T17:29:20Z","timestamp":1750181360000},"page":"e0322913","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The characteristics of latent tuberculosis infection and its influencing factors in hospitalized patients in Suzhou, Jiangsu, 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Deng","year":"1996","journal-title":"Nature"},{"issue":"1","key":"pone.0322913.ref034","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev.micro.50.1.825","article-title":"Immunopathogenesis of HIV infection","volume":"50","author":"G Pantaleo","year":"1996","journal-title":"Annu Rev Microbiol"},{"issue":"10","key":"pone.0322913.ref035","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/cells12101351","article-title":"HIV-host cell interactions","volume":"12","author":"SK Masenga","year":"2023","journal-title":"Cells"},{"issue":"5","key":"pone.0322913.ref036","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jinf.2020.02.009","article-title":"Effect of HIV-infection on QuantiFERON-plus accuracy in patients with active tuberculosis and latent infection","volume":"80","author":"E Petruccioli","year":"2020","journal-title":"J 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