{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:35:56Z","timestamp":1781534156274,"version":"3.54.5"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Hubei Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["2023AFB668"],"award-info":[{"award-number":["2023AFB668"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Acne vulgaris, a chronic inflammatory skin disorder, represents a pivotal research area in dermatology. Although fucoxanthin, a marine-derived carotenoid, displays potent anti-inflammatory activity, its therapeutic potential in acne pathogenesis remains underexplored.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>This study investigates fucoxanthin\u2019s effects on <jats:italic>Propionibacterium acnes<\/jats:italic> (<jats:italic>P.acnes<\/jats:italic>)-induced auricular inflammation in mice, focusing on its modulation of the I\u03baB\u03b1\/NF-\u03baB signaling axis and inhibition of NF-\u03baB nuclear translocation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Inflammation in the ear of mice was induced using a <jats:italic>P.acnes<\/jats:italic> injection model. The anti-inflammatory effects of fucoxanthin were verified by evaluating the levels of erythema, pathological damage, and inflammatory factors in the mice ear. An in vitro model was constructed to explore the regulatory mechanism of IkappaBalpha (I\u03baB\u03b1)\/nuclear factor-kappaB (NF-\u03baB) pathway by fucoxanthin.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Fucoxanthin alleviated <jats:italic>P. acnes<\/jats:italic>-induced inflammatory pathology, reducing ear erythema. Mechanistically, it preserved I\u03baB\u03b1 stability, suppressed NF-\u03baB nuclear translocation, and decreased proinflammatory cytokine production.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Fucoxanthin exerts anti-acne effects through coordinated inhibition of I\u03baB\u03b1 degradation and NF-\u03baB nuclear translocation, establishing its potential as a targeted therapeutic agent for inflammatory acne.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0322950","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T17:46:52Z","timestamp":1746640012000},"page":"e0322950","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fucoxanthin ameliorates Propionibacterium acnes-induced ear inflammation in mice by modulating the I\u03baB\u03b1\/NF-\u03baB signaling pathway and inhibiting NF-\u03baB nuclear translocation"],"prefix":"10.1371","volume":"20","author":[{"given":"Shan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-5572","authenticated-orcid":true,"given":"Hu","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"issue":"Suppl 1","key":"pone.0322950.ref001","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0924-8579(09)70541-2","article-title":"Skin and soft 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