{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:24:06Z","timestamp":1787315046907,"version":"build-2736575974"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Autonomous Province of Bolzano-South Tyrol Department of Innovation, Research, University and Museums and supported by the European Regional Development Fund","award":["FESR1157"],"award-info":[{"award-number":["FESR1157"]}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["860977"],"award-info":[{"award-number":["860977"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Chronic kidney disease (CKD) is a complex disease affecting &gt;10% of the global population, with large between- and within-continent variability reflecting major environmental determinants. To identify molecular targets for treatment and prevention, genome-wide association study meta-analyses (GWAMAs) of CKD-defining traits have identified hundreds of genetic loci in aggregated population samples. However, while GWAMAs estimate the average allelic effect across studies, single population studies may be relevant to unravel specific mechanisms. To assess whether a study sample from a specific population could extend existing knowledge on kidney function genetics, we selected 147 kidney function relevant loci identified by a large GWAMA, assessing their association with the glomerular filtration rate estimated from serum creatinine (eGFRcrea) in 10,146 participants to the Cooperative Health Research In South Tyrol (CHRIS) study, conducted in an Alpine region where thyroid dysfunction is common. We identified associations with single nucleotide polymorphisms (SNPs) at 11 loci, showing up-to-5.4 times larger effect sizes than in the corresponding GWAMA, not explainable by allele frequency differences. Systematic mediation analysis across 70 quantitative traits identified serum magnesium and the activated partial thromboplastin time as partial mediators of the eGFRcrea associations at\n                    <jats:italic>SHROOM3<\/jats:italic>\n                    and\n                    <jats:italic>SLC34A1<\/jats:italic>\n                    , respectively. Given that free triiodothyronine and thyroxine acted as effect modifiers across all loci, we conducted SNP-by-thyroid stimulating hormone (TSH) interaction analyses, identifying significant interactions at\n                    <jats:italic>STC1<\/jats:italic>\n                    : SNPs had larger effects on eGFRcrea at higher TSH levels, possibly reflecting stanniocalcin-1 autocrine and paracrine role. Individual population studies can help characterize genetic associations. The interplay between phenotypes at\n                    <jats:italic>SHROOM3<\/jats:italic>\n                    and\n                    <jats:italic>SLC34A1<\/jats:italic>\n                    and the role of thyroid function as a genetic effect modifier warrant further investigations.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0323057","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:48:27Z","timestamp":1750772907000},"page":"e0323057","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systematic mediation and interaction analyses of kidney function genetic loci in a general population study"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4043-815X","authenticated-orcid":true,"given":"Dariush","family":"Ghasemi-Semeskandeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8149-1072","authenticated-orcid":true,"given":"David","family":"Emmert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Foco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4785-4348","authenticated-orcid":true,"given":"Martin","family":"G\u00f6gele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0904-976X","authenticated-orcid":true,"given":"Mohamed S.","family":"Sarhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8139-4686","authenticated-orcid":true,"given":"Laura","family":"Barin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fuchsberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorien J. M.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Pramstaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Pattaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"issue":"9887","key":"pone.0323057.ref001","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0140-6736(13)60439-0","article-title":"Evolving importance of kidney disease: from subspecialty to global health burden","volume":"382","author":"K-U Eckardt","year":"2013","journal-title":"Lancet"},{"issue":"10159","key":"pone.0323057.ref002","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","article-title":"Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories","volume":"392","author":"KJ Foreman","year":"2018","journal-title":"Lancet"},{"issue":"10225","key":"pone.0323057.ref003","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","year":"2020","journal-title":"Lancet"},{"issue":"20","key":"pone.0323057.ref004","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1001\/jama.2014.15063","article-title":"Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans","volume":"312","author":"RP Naik","year":"2014","journal-title":"JAMA"},{"issue":"7","key":"pone.0323057.ref005","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1681\/ASN.2015050542","article-title":"CKD Prevalence Varies across the European General Population","volume":"27","author":"K Br\u00fcck","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"pone.0323057.ref006","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.kint.2019.10.027","article-title":"The CKDGen Consortium: ten years of insights into the genetic basis of kidney function","volume":"97","author":"A K\u00f6ttgen","year":"2020","journal-title":"Kidney Int"},{"issue":"6734","key":"pone.0323057.ref007","article-title":"Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants","volume":"387","author":"H Liu","year":"2025","journal-title":"Science"},{"issue":"2","key":"pone.0323057.ref008","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ajhg.2015.06.009","article-title":"The genetic basis of mendelian phenotypes: discoveries, challenges, and opportunities","volume":"97","author":"JX Chong","year":"2015","journal-title":"The American Journal of Human Genetics"},{"issue":"6572","key":"pone.0323057.ref009","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1126\/science.abe0348","article-title":"Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen","volume":"374","author":"ME Montasser","year":"2021","journal-title":"Science"},{"key":"pone.0323057.ref010","article-title":"PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study","author":"P Hamet","year":"2017","journal-title":"J Hypertens"},{"key":"pone.0323057.ref011","article-title":"Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population","author":"EM Humphries","year":"2023","journal-title":"Mol Psychiatry"},{"key":"pone.0323057.ref012","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s12967-015-0704-9","article-title":"The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results","volume":"13","author":"C Pattaro","year":"2015","journal-title":"J Transl Med"},{"issue":"3","key":"pone.0323057.ref013","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ki.2009.135","article-title":"Genome-wide linkage analysis of serum creatinine in three isolated European populations","volume":"76","author":"C Pattaro","year":"2009","journal-title":"Kidney Int"},{"key":"pone.0323057.ref014","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2350-11-41","article-title":"A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level","volume":"11","author":"C Pattaro","year":"2010","journal-title":"BMC Med Genet"},{"issue":"5","key":"pone.0323057.ref015","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1017\/S0021932009003423","article-title":"Fertility pattern and family structure in three Alpine settlements in South Tyrol (italy): marriage cohorts from 1750 to 1949","volume":"41","author":"M G\u00f6gele","year":"2009","journal-title":"J Biosoc Sci"},{"key":"pone.0323057.ref016","volume-title":"Prevalence of the Chronic Diseases","author":"AotPo Bolzano","year":"2019"},{"issue":"6","key":"pone.0323057.ref017","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41588-019-0407-x","article-title":"A catalog of genetic loci associated with kidney function from analyses of a million individuals","volume":"51","author":"M Wuttke","year":"2019","journal-title":"Nat Genet"},{"issue":"6","key":"pone.0323057.ref018","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00439-017-1785-8","article-title":"Sequential recruitment of study participants may inflate genetic heritability estimates","volume":"136","author":"D Noce","year":"2017","journal-title":"Hum Genet"},{"issue":"1","key":"pone.0323057.ref019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting Linear Mixed-Effects Models Using lme4","volume":"67","author":"D Bates","year":"2015","journal-title":"Journal of Statistical Software"},{"issue":"9","key":"pone.0323057.ref020","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"AS Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"pone.0323057.ref021","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000351043","article-title":"Estimating the glomerular filtration rate in the general population using different equations: effects on classification and association","volume":"123","author":"C Pattaro","year":"2013","journal-title":"Nephron Clin Pract"},{"issue":"4","key":"pone.0323057.ref022","article-title":"A general approach for haplotype phasing across the full spectrum of relatedness","volume":"10","author":"J O\u2019Connell","year":"2014","journal-title":"PLoS Genet"},{"issue":"10","key":"pone.0323057.ref023","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"S Das","year":"2016","journal-title":"Nat Genet"},{"issue":"1","key":"pone.0323057.ref024","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"J Yang","year":"2011","journal-title":"Am J Hum Genet"},{"issue":"4","key":"pone.0323057.ref025","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng.548","article-title":"Variance component model to account for sample structure in genome-wide association studies","volume":"42","author":"HM Kang","year":"2010","journal-title":"Nat Genet"},{"issue":"4","key":"pone.0323057.ref026","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"B Devlin","year":"1999","journal-title":"Biometrics"},{"issue":"16","key":"pone.0323057.ref027","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1093\/bioinformatics\/btaa570","article-title":"Metasubtract: an R-package to analytically produce leave-one-out meta-analysis GWAS summary statistics","volume":"36","author":"IM Nolte","year":"2020","journal-title":"Bioinformatics"},{"issue":"7","key":"pone.0323057.ref028","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/bioinformatics\/btt730","article-title":"CrossMap: a versatile tool for coordinate conversion between genome assemblies","volume":"30","author":"H Zhao","year":"2014","journal-title":"Bioinformatics"},{"issue":"8","key":"pone.0323057.ref029","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/aje\/kwr385","article-title":"Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence","volume":"175","author":"M G\u00f6gele","year":"2012","journal-title":"Am J Epidemiol"},{"issue":"1","key":"pone.0323057.ref030","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/bioinformatics\/bty547","article-title":"emeraLD: rapid linkage disequilibrium estimation with massive datasets","volume":"35","author":"C Quick","year":"2019","journal-title":"Bioinformatics"},{"issue":"22","key":"pone.0323057.ref031","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1093\/bioinformatics\/btz469","article-title":"PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations","volume":"35","author":"MA Kamat","year":"2019","journal-title":"Bioinformatics"},{"key":"pone.0323057.ref032","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac1010","article-title":"The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource","volume":"51","author":"E Sollis","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"pone.0323057.ref033","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1038\/s41467-018-06356-1","article-title":"Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation","volume":"9","author":"A Teumer","year":"2018","journal-title":"Nat Commun"},{"issue":"7","key":"pone.0323057.ref034","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41588-022-01097-w","article-title":"Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease","volume":"54","author":"H Liu","year":"2022","journal-title":"Nat Genet"},{"issue":"7982","key":"pone.0323057.ref035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"BB Sun","year":"2023","journal-title":"Nature"},{"issue":"12","key":"pone.0323057.ref036","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","article-title":"Large-scale integration of the plasma proteome with genetics and disease","volume":"53","author":"E Ferkingstad","year":"2021","journal-title":"Nat Genet"},{"issue":"6","key":"pone.0323057.ref037","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ng.377","article-title":"Multiple loci associated with indices of renal function and chronic kidney disease","volume":"41","author":"A K\u00f6ttgen","year":"2009","journal-title":"Nat Genet"},{"issue":"5","key":"pone.0323057.ref038","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng.568","article-title":"New loci associated with kidney function and chronic kidney disease","volume":"42","author":"A K\u00f6ttgen","year":"2010","journal-title":"Nat Genet"},{"issue":"1","key":"pone.0323057.ref039","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ajhg.2012.05.009","article-title":"Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease","volume":"91","author":"W Tang","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"8","key":"pone.0323057.ref040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001045","article-title":"Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels","volume":"6","author":"TE Meyer","year":"2010","journal-title":"PLoS Genet"},{"issue":"1","key":"pone.0323057.ref041","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1101\/gr.182881.114","article-title":"Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity","volume":"25","author":"NC Yeo","year":"2015","journal-title":"Genome Res"},{"issue":"10","key":"pone.0323057.ref042","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1681\/ASN.2015060621","article-title":"Developmental Origins for Kidney Disease Due to Shroom3 Deficiency","volume":"27","author":"H Khalili","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"pone.0323057.ref043","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ekir.2025.02.018","article-title":"Clinical and metabolic signatures of FAM47E-SHROOM3 haplotypes in a general population sample.","volume":"10","author":"D Ghasemi-Semeskandeh","year":"2025","journal-title":"Kidney Int Rep"},{"issue":"8","key":"pone.0323057.ref044","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/jmg.2010.088583","article-title":"Linkage and association analysis of hyperthyrotropinaemia in an Alpine population reveal two novel loci on chromosomes 3q28-29 and 6q26-27","volume":"48","author":"CB Volpato","year":"2011","journal-title":"J Med Genet"},{"key":"pone.0323057.ref045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2350-8-29","article-title":"The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectives","volume":"8","author":"C Pattaro","year":"2007","journal-title":"BMC Med Genet"},{"issue":"1","key":"pone.0323057.ref046","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/gerona\/glq163","article-title":"Heritability analysis of life span in a semi-isolated population followed across four centuries reveals the presence of pleiotropy between life span and reproduction","volume":"66","author":"M G\u00f6gele","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"5","key":"pone.0323057.ref047","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1017\/S0021932007002568","article-title":"Isolation and marriage patterns in four South Tyrolean villages (Italy) during the nineteenth century","volume":"40","author":"A Riegler","year":"2008","journal-title":"J Biosoc Sci"},{"issue":"5","key":"pone.0323057.ref048","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1681\/ASN.2017080856","article-title":"Characterization of coding\/noncoding variants for SHROOM3 in patients with CKD","volume":"29","author":"JW Prokop","year":"2018","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"pone.0323057.ref049","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31447","article-title":"CCDC158: A novel regulator in renal proximal tubular endocytosis unveiled through exome sequencing and interactome analysis","volume":"239","author":"T Bondue","year":"2024","journal-title":"J Cell Physiol"},{"issue":"8","key":"pone.0323057.ref050","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1242\/dev.044610","article-title":"Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut","volume":"137","author":"M-I Chung","year":"2010","journal-title":"Development"},{"issue":"2","key":"pone.0323057.ref051","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1684\/mrh.2012.0309","article-title":"Serum magnesium: a biomarker of cardiovascular risk revisited?","volume":"25","author":"LC Del Gobbo","year":"2012","journal-title":"Magnes Res"},{"issue":"4","key":"pone.0323057.ref052","first-page":"394","article-title":"Understanding renal phosphate handling: unfinished business","volume":"32","author":"E Lederer","year":"2023","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"12","key":"pone.0323057.ref053","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1056\/NEJMoa0905647","article-title":"A loss-of-function mutation in NaPi-IIa and renal Fanconi\u2019s syndrome","volume":"362","author":"D Magen","year":"2010","journal-title":"N Engl J Med"},{"key":"pone.0323057.ref054","volume-title":"Diagnosis of hemophilia and other bleeding disorders","author":"S Kitchen","year":"2010"},{"issue":"6390","key":"pone.0323057.ref055","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1126\/science.aar2131","article-title":"Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease","volume":"360","author":"J Park","year":"2018","journal-title":"Science"},{"key":"pone.0323057.ref056","article-title":"Adaptations to water stress and pastoralism in the Turkana of northwest Kenya","author":"AJ Lea","year":"2023","journal-title":"bioRxiv"},{"issue":"14","key":"pone.0323057.ref057","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1111\/jcmm.15348","article-title":"Expression, function and clinical application of stanniocalcin-1 in cancer","volume":"24","author":"F Zhao","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"3","key":"pone.0323057.ref058","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002584","article-title":"Genome-wide association and functional follow-up reveals new loci for kidney function","volume":"8","author":"C Pattaro","year":"2012","journal-title":"PLoS Genet"},{"issue":"1","key":"pone.0323057.ref059","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1038\/ncomms10023","article-title":"Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function","volume":"7","author":"C Pattaro","year":"2016","journal-title":"Nature Communications"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0323057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:48:39Z","timestamp":1750772919000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0323057"}},"subtitle":[],"editor":[{"given":"Andrew J.","family":"Mallett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":59,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0323057","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.04.15.23288540","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}