{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:16:59Z","timestamp":1780575419216,"version":"3.54.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030692","name":"Intramural Research Program, National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R34DA054870"],"award-info":[{"award-number":["R34DA054870"]}],"id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Black sexual minority men (SMM) are disproportionately affected by HIV. Pre-exposure prophylaxis (PrEP) is a medication that reduces HIV acquisition. There is a gap in our understanding of the acceptability of and preference for on-demand and long-acting injectable (LAI)-PrEP among PrEP-eligible Black SMM. This study aimed to explore preference for on-demand and LAI-PrEP and reasons for those preferences among HIV-negative Black SMM of different PrEP use profiles (current PrEP users, current non-PrEP users, and PrEP discontinuers).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Between March 2022 and April 2023, we conducted 17 focus group discussions (FGDs) with a total of 58 HIV-negative (current PrEP users, non-PrEP users, and PrEP discontinuers) Black SMM residing in the Washington D.C.\u00a0metropolitan area. We explored acceptability and interest in on-demand and LAI-PrEP and anticipated barriers and facilitators to uptake.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Two key themes emerged around interest and preferences for on-demand PrEP and LAI-PrEP: 1) lack of interest in on-demand PrEP, and 2) high acceptability of LAI-PrEP. The reasons for lack of interest in on-demand PrEP were: 1) inability to accurately anticipate and plan for sexual activity in advance, 2) uncertainty about effectiveness of on-demand PrEP, and 3) potential for unnecessary medication use, especially when anticipated sexual activity doesn\u2019t occur. Most participants finding LAI-PrEP to be highly acceptable can be attributable to: 1) LAI-PrEP being convenient, and 2) LAI-PrEP being a potential solution to suboptimal adherence to daily oral PrEP due to forgetfulness.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Discussion<\/jats:title>\n<jats:p>While daily oral PrEP is the most utilized PrEP modality, some SMM\u2014who might not be acceptable to oral PrEP\u2014are capable of accurately identifying specific periods and circumstances for HIV infection. It is important that healthcare providers present on-demand PrEP as an option to individuals who fall into these categories. Programs to increase awareness and knowledge of LAI-PrEP among Black SMM and HCP that serve them are needed. Additionally, it is imperative that HCP who provide PrEP services receive proper training on the administration of LAI-PrEP and that there is dedicated staff to help clients navigate the insurance coverage process.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0323212","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T17:25:56Z","timestamp":1751304356000},"page":"e0323212","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preferences for on-demand\/intermittent\/event-driven and long-acting injectable (LAI) HIV pre-exposure prophylaxis (PrEP) among HIV-negative Black gay, bisexual, and other sexual minority men in the United States: A qualitative study"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-6431","authenticated-orcid":true,"given":"Adedotun","family":"Ogunbajo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Euceda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raven","family":"Ekundayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope","family":"Oke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeMarc","family":"Hickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"issue":"9839","key":"pone.0323212.ref001","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(12)60899-X","article-title":"Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: a meta-analysis","volume":"380","author":"GA Millett","year":"2012","journal-title":"Lancet"},{"issue":"5","key":"pone.0323212.ref002","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/infdis\/jiv500","article-title":"Age-specific race and ethnicity disparities in HIV infection and awareness among men who have sex with men\u201420 US cities, 2008\u20132014","volume":"213","author":"C Wejnert","year":"2016","journal-title":"The Journal of Infectious Diseases"},{"issue":"27","key":"pone.0323212.ref003","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1056\/NEJMoa1011205","article-title":"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men","volume":"363","author":"RM Grant","year":"2010","journal-title":"N Engl J Med"},{"key":"pone.0323212.ref004","unstructured":"Prevention CfDCa. Core indicators for monitoring the Ending the HIV Epidemic initiative (preliminary data): National HIV Surveillance System data reported through June 2023; and preexposure prophylaxis (PrEP) data reported through March 2023. 2023."},{"issue":"37","key":"pone.0323212.ref005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.15585\/mmwr.mm6837a2","article-title":"Racial\/Ethnic Disparities in HIV Preexposure Prophylaxis Among Men Who Have Sex with Men - 23 Urban Areas, 2017","volume":"68","author":"D Kanny","year":"2019","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"10","key":"pone.0323212.ref006","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1007\/s10461-019-02641-2","article-title":"The PrEP Care Continuum and Black Men Who Have Sex with Men: A Scoping Review of Published Data on Awareness, Uptake, Adherence, and Retention in PrEP Care","volume":"23","author":"O Ezennia","year":"2019","journal-title":"AIDS 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the way for pre-exposure HIV prophylaxis","volume":"380","author":"D Holmes","year":"2012","journal-title":"Lancet"},{"issue":"8","key":"pone.0323212.ref010","article-title":"Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study","volume":"9","author":"J-M Molina","year":"2022","journal-title":"Lancet HIV"},{"issue":"9","key":"pone.0323212.ref011","article-title":"Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study","volume":"4","author":"J-M Molina","year":"2017","journal-title":"Lancet HIV"},{"issue":"23","key":"pone.0323212.ref012","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMoa1506273","article-title":"On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection","volume":"373","author":"J-M Molina","year":"2015","journal-title":"N Engl J 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Carneiro","year":"2021","journal-title":"AIDS Behav"},{"issue":"2","key":"pone.0323212.ref016","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/QAI.0000000000001791","article-title":"Choosing Between Daily and Event-Driven Pre-exposure Prophylaxis: Results of a Belgian PrEP Demonstration Project","volume":"79","author":"T Reyniers","year":"2018","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"8","key":"pone.0323212.ref017","article-title":"Willingness of community-recruited men who have sex with men in Washington, DC to use long-acting injectable HIV pre-exposure prophylaxis","volume":"12","author":"ME Levy","year":"2017","journal-title":"PLoS One"},{"issue":"7","key":"pone.0323212.ref018","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1007\/s10461-022-03575-y","article-title":"Acceptability of and Preferences for Long-Acting Injectable HIV PrEP and Other PrEP Modalities among Sexual Minority Men in Nigeria, Africa","volume":"26","author":"A Ogunbajo","year":"2022","journal-title":"AIDS Behav"},{"key":"pone.0323212.ref019","article-title":"Who prefers what? Correlates of preferences for next-generation HIV prevention products among a national U.S. sample of young men who have sex with men","author":"KB Biello","year":"2023","journal-title":"J Int AIDS Soc"},{"key":"pone.0323212.ref020","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fpubh.2017.00341","article-title":"Baseline preferences for daily, event-driven, or periodic HIV pre-exposure prophylaxis among gay and bisexual men in the PRELUDE demonstration project","volume":"5","author":"SJ Vaccher","year":"2017","journal-title":"Frontiers in public health"},{"issue":"5","key":"pone.0323212.ref021","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1007\/s10461-016-1565-9","article-title":"Preferences for Long-Acting Pre-exposure Prophylaxis (PrEP), Daily Oral PrEP, or Condoms for HIV Prevention Among U.S. Men Who Have Sex with Men","volume":"21","author":"GJ Greene","year":"2017","journal-title":"AIDS Behav"},{"key":"pone.0323212.ref022","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1007\/s10461-017-1972-6","article-title":"MSM at highest risk for HIV acquisition express greatest interest and preference for injectable antiretroviral PrEP compared to daily, oral medication","volume":"22","author":"KB Biello","year":"2018","journal-title":"AIDS and Behavior"},{"issue":"12","key":"pone.0323212.ref023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209484","article-title":"Pre-exposure prophylaxis for HIV prevention preferences among young adult African American men who have sex with men","volume":"13","author":"RR Patel","year":"2018","journal-title":"PLoS One"},{"issue":"10","key":"pone.0323212.ref024","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1007\/s10461-022-03684-8","article-title":"Who is using PrEP on-demand? Factors associated with PrEP use modality among Black and Hispanic\/Latino emerging adults","volume":"26","author":"AE Caba","year":"2022","journal-title":"AIDS Behav"},{"key":"pone.0323212.ref025","article-title":"Understanding pre-exposure prophylaxis (PrEP) regimen use: switching and discontinuing daily and event-driven PrEP among men who have sex with men","volume":"29","author":"L Coyer","year":"2020","journal-title":"EClinicalMedicine"},{"issue":"8","key":"pone.0323212.ref026","doi-asserted-by":"crossref","DOI":"10.1002\/jia2.25768","article-title":"Choosing event-driven and daily HIV pre-exposure prophylaxis - data from two European PrEP demonstration projects among men who have sex with men","volume":"24","author":"VW Jongen","year":"2021","journal-title":"J Int AIDS Soc"},{"key":"pone.0323212.ref027","article-title":"Human Immunodeficiency Virus (HIV) Seroconversion Among Men Who Have Sex With Men Who Use Event-Driven or Daily Oral Pre-Exposure Prophylaxis (CohMSM-PrEP): A Multi-Country Demonstration Study From West Africa","author":"C Laurent","year":"2023","journal-title":"Clinical Infectious Diseases"},{"issue":"4","key":"pone.0323212.ref028","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/QAI.0000000000003370","article-title":"Barriers and facilitators to long-acting injectable HIV pre-exposure prophylaxis implementation in primary care since its approval in the United States","volume":"95","author":"S Keddem","year":"2024","journal-title":"JAIDS Journal of Acquired Immune Deficiency Syndromes"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0323212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T17:26:05Z","timestamp":1751304365000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0323212"}},"subtitle":[],"editor":[{"given":"Douglas S.","family":"Krakower","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":28,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0323212","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}