{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T04:05:22Z","timestamp":1746763522534,"version":"3.40.5"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ENDOFRANCE Association"},{"DOI":"10.13039\/501100002915","name":"Foundation for Medical Research","doi-asserted-by":"crossref","award":["FRE202311018602"],"award-info":[{"award-number":["FRE202311018602"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec022\">\n<jats:title>Background<\/jats:title>\n<jats:p>Surgery remains the gold standard for management of endometriosis, offering significant improvement in patient pelvic pain and quality of life (QoL). Postoperative tissue adhesions can however diminish these benefits, limiting the long-term effectiveness of the intervention. Despite the development of strategies and devices to reduce adhesion formation, their efficacy remains inconclusive.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec023\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aims to propose and evaluate a novel approach involving early visceral mobilization and training of patients in abdominal self-mobilization as a means to improve QoL following surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec024\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This pilot study is a prospective, randomized, phase II superiority trial. Patients undergoing surgery for infiltrating endometriosis will be randomized, with a 2:1 ratio, into two groups. The intervention group (n\u2009=\u200942) will receive six sessions of osteopathic visceral mobilization with training in abdominal self-mobilization techniques, one preoperative, and five postoperative during the first month post-surgery. The control group (n\u2009=\u200921) will receive no osteopathic visceral mobilizations but will be offered an osteopathic session after one year. The primary endpoint is a minimum increase of 20 points (on a 100-point scale) in the Endometriosis Health Profile-30 (EHP-30) global score, at one year. Secondary endpoints include assessment of gastrointestinal quality of life (GIQLI), sexual function (FSFI), urinary symptoms (ICIQ-FLUTS), pain catastrophizing (PCS), as well as scar examination, pelvic pain, abdominal flexibility, use of medical and non-medical care, analgesic and hormonal treatments, pregnancy rate, physical activity, sedentary lifestyle and patient compliance. Statistical analyses will be based on a one-sided \u03b1=0.05 and \u03b2=0.15, assuming a standard deviation of 25 points in the EHP-30 global score. A total of 42 participants in the intervention group and 21 in the control group are required.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec025\">\n<jats:title>Discussion<\/jats:title>\n<jats:p>This trial aims to demonstrate that early and repeated osteopathic sessions following surgery for endometriosis may significantly improve patient QoL.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0323214","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T17:34:44Z","timestamp":1746725684000},"page":"e0323214","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pilot study MOVENDOP protocol - impact on quality of life following postoperative osteopathic abdominal mobilizations in patients operated for endometriosis"],"prefix":"10.1371","volume":"20","author":[{"given":"Aur\u00e9lie","family":"Comptour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Dechambenoit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4041-3999","authenticated-orcid":true,"given":"Fabrice","family":"Kwiatkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Duval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"De Antonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-9779","authenticated-orcid":true,"given":"Aur\u00e9lie","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Bourdel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"pone.0323214.ref001","article-title":"Physiopathologie de l\u2019endom\u00e9triose. \/data\/traites\/gy\/00-44636\/ [Internet]","author":"L Velemir","year":"23"},{"issue":"11","key":"pone.0323214.ref002","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","article-title":"Endometriosis: Etiology, pathobiology, and therapeutic prospects","volume":"184","author":"PTK Saunders","year":"2021","journal-title":"Cell"},{"issue":"9447","key":"pone.0323214.ref003","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"LC Giudice","year":"2004","journal-title":"Lancet"},{"key":"pone.0323214.ref004","unstructured":"Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) - PubMed [Internet]. 2024. Disponible sur: https:\/\/pubmed.ncbi.nlm.nih.gov\/34638893\/"},{"key":"pone.0323214.ref005","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.14817.1","article-title":"Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment","volume":"8","author":"E Rolla","year":"2019","journal-title":"F1000Res"},{"issue":"1","key":"pone.0323214.ref006","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/humupd\/dmu046","article-title":"Systematic review of endometriosis pain assessment: how to choose a scale?","volume":"21","author":"N Bourdel","year":"2015","journal-title":"Hum Reprod Update"},{"issue":"3","key":"pone.0323214.ref007","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jogoh.2017.02.004","article-title":"Psychometric properties of the French version of the Endometriosis Health Profile-30, a health-related quality of life instrument","volume":"46","author":"P Chauvet","year":"2017","journal-title":"J Gynecol Obstet Hum Reprod"},{"issue":"4","key":"pone.0323214.ref008","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jmig.2018.08.005","article-title":"Patient quality of life and symptoms after surgical treatment for endometriosis","volume":"26","author":"A Comptour","year":"2019","journal-title":"J Minim Invasive Gynecol"},{"issue":"8","key":"pone.0323214.ref009","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9082461","article-title":"Long-term evolution of quality of life and symptoms following surgical treatment for endometriosis: different trajectories for which patients?","volume":"9","author":"A Comptour","year":"2020","journal-title":"J Clin Med"},{"key":"pone.0323214.ref010","article-title":"Identification of predictive factors in endometriosis for improvement in patient quality of life","author":"A Comptour","year":"2019","journal-title":"J Minim Invasive Gynecol"},{"issue":"1","key":"pone.0323214.ref011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208464","article-title":"Systematic review of quality of life measures in patients with endometriosis","volume":"14","author":"N Bourdel","year":"2019","journal-title":"PLoS One"},{"issue":"5","key":"pone.0323214.ref012","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.fertnstert.2006.03.048","article-title":"Relationship between delay of surgical diagnosis and severity of disease in patients with symptomatic deep infiltrating endometriosis","volume":"86","author":"S Matsuzaki","year":"2006","journal-title":"Fertil Steril"},{"issue":"3","key":"pone.0323214.ref013","first-page":"209","article-title":"Diagnostic strategies for endometriosis: CNGOF-HAS Endometriosis Guidelines","volume":"46","author":"N Bourdel","year":"2018","journal-title":"Gynecol Obstet Fertil Senol"},{"issue":"4","key":"pone.0323214.ref014","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1055\/s-0028-1082389","article-title":"Postoperative adhesions: from formation to prevention.","volume":"26","author":"Z Alpay","year":"2008","journal-title":"Semin Reprod Med"},{"issue":"4","key":"pone.0323214.ref015","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10397-012-0764-2","article-title":"Prevention of adhesions in gynaecological surgery: the 2012 European field guideline","volume":"9","author":"RL De Wilde","year":"2012","journal-title":"Gynecol Surg"},{"key":"pone.0323214.ref016","first-page":"5","article-title":"Adh\u00e9rences pelvienne et fertilit\u00e9: o\u00f9 en est-on en 2018? Journal de Chirurgie Visc\u00e9rale","volume":"155","author":"M Canis","year":"2018","journal-title":"1 juin"},{"key":"pone.0323214.ref017","first-page":"221","article-title":"Peritoneal adhesions and their prevention - current trends","volume":"38","author":"B Kr\u00e4mer","year":"20","journal-title":"Surg Technol Int"},{"issue":"1","key":"pone.0323214.ref018","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jss.2009.09.015","article-title":"Abdominal adhesions: current and novel therapies","volume":"165","author":"BC Ward","year":"2011","journal-title":"J Surg Res"},{"issue":"1","key":"pone.0323214.ref019","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jmig.2006.07.013","article-title":"Surgical adhesions: a timely update, a great challenge for the future","volume":"14","author":"AK Davey","year":"2007","journal-title":"J Minim Invasive Gynecol"},{"issue":"6","key":"pone.0323214.ref020","doi-asserted-by":"crossref","DOI":"10.1007\/s00464-003-9233-3","article-title":"Fewer adhesions induced by laparoscopic surgery?","volume":"18","author":"C Gutt","journal-title":"Surg Endosc"},{"issue":"4","key":"pone.0323214.ref021","article-title":"Barrier agents for adhesion prevention after gynaecological surgery","volume":"2015","author":"G Ahmad","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"pone.0323214.ref022","first-page":"419","article-title":"Postoperative abdominal adhesions and their prevention in gynaecological surgery: II. How can they be prevented?","volume":"40","author":"J-L Pouly","year":"2012","journal-title":"Gynecol Obstet Fertil"},{"issue":"12","key":"pone.0323214.ref023","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1177\/1933719111414206","article-title":"Postoperative adhesion development following cesarean and open intra-abdominal gynecological operations: a review","volume":"18","author":"AO Awonuga","year":"2011","journal-title":"Reprod Sci"},{"issue":"3","key":"pone.0323214.ref024","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00595-013-0591-8","article-title":"Adhesions after abdominal surgery: a systematic review of the incidence, distribution and severity","volume":"44","author":"K Okabayashi","year":"2014","journal-title":"Surg Today"},{"issue":"3","key":"pone.0323214.ref025","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0015-0282(16)55274-1","article-title":"Second-look laparoscopy after laparoscopic cystectomy of large ovarian endometriomas","volume":"58","author":"M Canis","journal-title":"Fertil Steril"},{"issue":"6","key":"pone.0323214.ref026","first-page":"365","article-title":"Postoperative abdominal adhesions and their prevention in gynaecological surgery: I. What should you know?","volume":"40","author":"A Audebert","year":"2012","journal-title":"Gynecol Obstet Fertil"},{"issue":"3","key":"pone.0323214.ref027","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10397-007-0338-x","article-title":"Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position","volume":"4","author":"RL DeWilde","year":"2007","journal-title":"Gynecol Surg"},{"issue":"3","key":"pone.0323214.ref028","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00404-014-3312-7","article-title":"Consensus recommendations on adhesions (version 2014) for the ESGE Adhesions Research Working Group (European Society for Gynecological Endoscopy): an expert opinion","volume":"290","author":"RL De Wilde","year":"2014","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"pone.0323214.ref029","first-page":"243","article-title":"Postoperative abdominal adhesions and their prevention in gynaecological surgery","volume":"4","author":"RL DeWilde","year":"2007","journal-title":"Expert consensus position. Part 2\u2014steps to reduce adhesions. Gynecol Surg"},{"issue":"7","key":"pone.0323214.ref030","article-title":"Fluid and pharmacological agents for adhesion prevention after gynaecological surgery","author":"G Ahmad","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"pone.0323214.ref031","doi-asserted-by":"crossref","first-page":"8250952","DOI":"10.1155\/2018\/8250952","article-title":"Prevention and management of complications in laparoscopic myomectomy","volume":"2018","author":"V Tanos","year":"2018","journal-title":"Biomed Res Int"},{"issue":"4","key":"pone.0323214.ref032","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00404-011-2097-1","article-title":"A review of the problematic adhesion prophylaxis in gynaecological surgery","volume":"285","author":"A Hirschelmann","year":"2012","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"pone.0323214.ref033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm2010001","article-title":"Manual physical therapy for non-surgical treatment of adhesion-related small bowel obstructions: two case reports","volume":"2","author":"AD Rice","year":"2013","journal-title":"J Clin Med"},{"issue":"3","key":"pone.0323214.ref034","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1089\/jpm.2012.0458","article-title":"Clearing bowel obstruction and decreasing pain in a terminally ill patient via manual physical therapy","volume":"16","author":"AD Rice","year":"2013","journal-title":"J Palliat Med"},{"issue":"12","key":"pone.0323214.ref035","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2519\/jospt.2015.5766","article-title":"Soft tissue mobilization to resolve chronic pain and dysfunction associated with postoperative abdominal and pelvic adhesions: a case report","volume":"45","author":"YY Wong","year":"2015","journal-title":"J Orthop Sports Phys Ther"},{"issue":"2","key":"pone.0323214.ref036","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jbmt.2018.06.004","article-title":"Effect of soft tissue mobilization techniques on adhesion-related pain and function in the abdomen: A systematic review","volume":"23","author":"JB Wasserman","year":"2019","journal-title":"J Bodyw Mov Ther"},{"issue":"2","key":"pone.0323214.ref037","first-page":"51","article-title":"Treating female infertility and improving IVF pregnancy rates with a manual physical therapy technique","volume":"6","author":"BF Wurn","year":"2004","journal-title":"MedGenMed"},{"key":"pone.0323214.ref038","first-page":"453","article-title":"The role of the diaphragm in lymphatic absorption from the peritoneal cavity","volume":"186","author":"MF Abu-Hijleh","year":"1995","journal-title":"J Anat"},{"issue":"1","key":"pone.0323214.ref039","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2741\/E618","article-title":"Surgery for deep infiltrating endometriosis: technique and rationale","volume":"5","author":"W Kondo","year":"2013","journal-title":"Front Biosci (Elite Ed)"},{"issue":"12","key":"pone.0323214.ref040","first-page":"709","article-title":"Surgery for the management of ovarian endometriomas: from the physiopathology to the pre-, peri- and postoperative treatment","volume":"39","author":"N Bourdel","year":"2011","journal-title":"Gynecol Obstet Fertil"},{"issue":"2","key":"pone.0323214.ref041","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/aogs.13260","article-title":"Long-term evaluation of painful symptoms and fertility after surgery for large rectovaginal endometriosis nodule: a retrospective study","volume":"97","author":"N Bourdel","year":"2018","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"5","key":"pone.0323214.ref042","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jmig.2015.03.019","article-title":"Laparoscopic Ureteroneocystostomy: Be Prepared!","volume":"22","author":"N Bourdel","year":"2015","journal-title":"J Minim Invasive Gynecol"},{"issue":"1","key":"pone.0323214.ref043","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/acm.2015.0343","article-title":"The practice of hatha yoga for the treatment of pain associated with endometriosis","volume":"23","author":"AV Gon\u00e7alves","year":"2017","journal-title":"J Altern Complement Med"},{"issue":"2","key":"pone.0323214.ref044","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/jwh.2019.7788","article-title":"Responsiveness evaluation and recommendation for responder thresholds for endometriosis health profile-30: analysis of two phase III Clinical Trials","volume":"29","author":"R Pokrzywinski","year":"2020","journal-title":"J Womens Health (Larchmt)"},{"key":"pone.0323214.ref045","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners","volume":"95","author":"PA Harris","year":"2019","journal-title":"J Biomed Inform"},{"issue":"2","key":"pone.0323214.ref046","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"PA Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"pone.0323214.ref047","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2288-2-8","article-title":"Do multiple outcome measures require p-value adjustment?","volume":"2","author":"RJ Feise","year":"2002","journal-title":"BMC Med Res Methodol"},{"issue":"1","key":"pone.0323214.ref048","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jbmt.2011.02.004","article-title":"Visceral mobilization can lyse and prevent peritoneal adhesions in a rat model","volume":"16","author":"GM Bove","year":"2012","journal-title":"J Bodyw Mov Ther"},{"issue":"1","key":"pone.0323214.ref049","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1091-255X(01)00009-9","article-title":"Does mechanical massage of the abdominal wall after colectomy reduce postoperative pain and shorten the duration of ileus? Results of a randomized study","volume":"6","author":"I Le Blanc-Louvry","year":"2002","journal-title":"J Gastrointest Surg"},{"issue":"3","key":"pone.0323214.ref050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/JWH.0000000000000103","article-title":"Soft tissue mobilization techniques are effective in treating chronic pain following cesarean section: a multicenter Randomized Clinical Trial","volume":"42","author":"JB Wasserman","year":"2018","journal-title":"J Women\u2019s Health Physical Therapy"},{"issue":"2","key":"pone.0323214.ref051","first-page":"711","article-title":"Cosmetic breast surgery","volume":"45","author":"DA Field","year":"1992","journal-title":"Am Fam Physician"},{"issue":"9","key":"pone.0323214.ref052","first-page":"543","article-title":"Ultrasonography-guided osteopathic manipulative treatment for a patient with thoracic outlet syndrome","volume":"111","author":"BM Sucher","year":"2011","journal-title":"J Am Osteopath Assoc"},{"issue":"9","key":"pone.0323214.ref053","first-page":"472","article-title":"Impact of osteopathic manipulative therapy in patient with deep with colorectal endometriosis: A classification based on symptoms and quality of life","volume":"45","author":"C Dara\u00ef","year":"sept 2017","journal-title":"Gynecol Obstet Fertil Senol"},{"key":"pone.0323214.ref054","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejogrb.2015.03.001","article-title":"Impact of osteopathic manipulative therapy on quality of life of patients with deep infiltrating endometriosis with colorectal involvement: results of a pilot study","volume":"188","author":"C Dara\u00ef","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"pone.0323214.ref055","first-page":"3","article-title":"Douleurs et endom\u00e9triose","volume":"21","author":"N Bourdel","year":"2020","journal-title":"Douleurs\u00a0: \u00c9valuation - Diagnostic - Traitement"},{"issue":"2","key":"pone.0323214.ref056","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.rbmo.2018.10.009","article-title":"The use of home remedies and complementary health approaches in endometriosis","volume":"38","author":"ASK Schwartz","year":"2019","journal-title":"Reprod Biomed Online"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0323214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T17:34:55Z","timestamp":1746725695000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0323214"}},"subtitle":[],"editor":[{"given":"Jennifer","family":"Tucker","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":56,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0323214","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]}}}