{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T01:08:07Z","timestamp":1775956087408,"version":"3.50.1"},"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["PJT-162191"],"award-info":[{"award-number":["PJT-162191"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Sciences and Engineering Research Coucil of Canada","award":["RGPIN-2018-04991"],"award-info":[{"award-number":["RGPIN-2018-04991"]}]},{"DOI":"10.13039\/501100000233","name":"Genome British Columbia","doi-asserted-by":"publisher","award":["374PRO"],"award-info":[{"award-number":["374PRO"]}],"id":[{"id":"10.13039\/501100000233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>The protein Yin-Yang 1 (YY1) is a ubiquitous multifunctional transcription factor. Interestingly, there are several cellular functions controlled by YY1 that could play a role in <jats:italic>Leishmania<\/jats:italic> pathogenesis. Leishmaniasis is a human disease caused by protozoan parasites of the genus <jats:italic>Leishmania.<\/jats:italic> This study examined the potential role of macrophage YY1 in promoting <jats:italic>Leishmania<\/jats:italic> intracellular survival. Deliberate knockdown of YY1 resulted in attenuated survival of <jats:italic>Leishmania<\/jats:italic> in infected macrophages, suggesting a role of YY1 in <jats:italic>Leishmania<\/jats:italic> persistence. Biochemical fractionation studies revealed <jats:italic>Leishmania<\/jats:italic> infection caused redistribution of YY1 to the cytoplasm from the nucleus where it is primarily located. Inhibition of nuclear transport by leptomycin B attenuates infection-mediated YY1 redistribution and reduces <jats:italic>Leishmania<\/jats:italic> survival. This suggests that <jats:italic>Leishmania<\/jats:italic> induces the translocation of YY1 from the nucleus to the cytoplasm of infected cells, where it may regulate host molecules to favour parasite survival. A label-free quantitative whole proteome approach showed that the expression of a large number of macrophage proteins was dependent on the YY1 level. Interestingly, several of these proteins were modulated in <jats:italic>Leishmania<\/jats:italic>-infected cells, revealing YY1-dependent host response and suggesting their potential role in <jats:italic>Leishmania<\/jats:italic> pathogenesis. Together, this study identifies YY1 as a novel virulence factor that promotes <jats:italic>Leishmania<\/jats:italic> survival inside host macrophages.<\/jats:p>","DOI":"10.1371\/journal.pone.0323227","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T17:32:57Z","timestamp":1747330377000},"page":"e0323227","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Leishmania regulates host YY1: Comparative proteomic analysis identifies infection modulated YY1 dependent proteins"],"prefix":"10.1371","volume":"20","author":[{"given":"Harsimran Kaur","family":"Brar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawna Angel","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilraj Kaur","family":"Longowal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-720X","authenticated-orcid":true,"given":"Kyung-Mee","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard J.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6332-4841","authenticated-orcid":true,"given":"Devki","family":"Nandan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"pone.0323227.ref001","volume-title":"Leishmaniasis. 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