{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:17:46Z","timestamp":1792084666965,"version":"4.4.0"},"reference-count":149,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Alzheimer\u2019s disease varies by sex but is broadly characterized by widespread neurodegeneration and the accumulation of insoluble amyloid plaques and neurofibrillary tangles. However, at the earliest stages of the disease cell death and pathological tau are localized to the entorhinal cortex. In particular, the lateral entorhinal cortex, and its functions in object-related memory, are among the most vulnerable in aging. Notably, the entorhinal cortex projects directly to the dentate gyrus subregion of the hippocampus, where neurogenesis proceeds throughout adult life. Immature, adult-born neurons provide plasticity at the entorhinal-dentate pathway and they may be uniquely responsive, or vulnerable, to early entorhinal tau pathology. To test this, we injected a human tau-expressing recombinant adeno-associated virus (hTau) into the lateral entorhinal cortex and used male and female AsclCreER mice to birthdate downstream dentate neurons born in early postnatal development or adulthood. Consistent with known roles in neurodegeneration, lateral entorhinal hTau expression caused a loss of mushroom spines in downstream dentate gyrus neurons of male and female mice and reduced dendritic complexity of adult-born neurons in male mice. Presynaptic hTau also increased neurogenesis levels and increased the density of thin spines on adult-born neurons in both male and female mice. Consistent with spine addition, hTau increased the slope of the synaptic input-output curves; amongst adult-born neurons, this was due to a specific effect on synapses in male mice. hTau did not alter the magnitude of long-term potentiation at entorhinal synapses onto adult- or developmentally-born neurons. Thus, in a novel model of early sporadic tau pathology, there are changes consistent with neurodegeneration but also compensatory neuroplastic changes, caused in part by neurogenesis. Since immature neurons have also been identified in the human dentate gyrus, a similar neurogenic plasticity may help maintain entorhinal-hippocampal formation in pathological aging.<\/jats:p>","DOI":"10.1371\/journal.pone.0323230","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:32:51Z","timestamp":1765391571000},"page":"e0323230","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus"],"prefix":"10.1371","volume":"20","author":[{"given":"Alyssa M.","family":"Ash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue Rim","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyton","family":"Holder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Vyleta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Willman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-0272","authenticated-orcid":true,"given":"Jason S.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"issue":"3","key":"pone.0323230.ref001","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jalz.2007.04.381","article-title":"Forecasting the global burden of Alzheimer\u2019s disease","volume":"3","author":"R Brookmeyer","year":"2007","journal-title":"Alzheimers Dement"},{"issue":"1","key":"pone.0323230.ref002","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1474-4422(15)00323-3","article-title":"Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study","volume":"15","author":"CR Jack","year":"2016","journal-title":"Lancet Neurol"},{"issue":"7","key":"pone.0323230.ref003","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.neurobiolaging.2009.04.002","article-title":"Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease","volume":"30","author":"JL Price","year":"2009","journal-title":"Neurobiol Aging"},{"issue":"2","key":"pone.0323230.ref004","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jalz.2017.10.009","article-title":"Forecasting the prevalence of preclinical and clinical Alzheimer\u2019s disease in the United States","volume":"14","author":"R Brookmeyer","year":"2018","journal-title":"Alzheimers Dement"},{"key":"pone.0323230.ref005","unstructured":"Association A. Changing the Trajectory of Alzheimer\u2019s Disease: How a Treatment by 2025 Saves Lives and Dollars. 2015."},{"issue":"8","key":"pone.0323230.ref006","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","article-title":"Sex differences in Alzheimer disease - the gateway to precision medicine","volume":"14","author":"MT Ferretti","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"pone.0323230.ref007","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.neuron.2024.01.024","article-title":"Mechanisms of sex differences in Alzheimer\u2019s disease","volume":"112","author":"C Lopez-Lee","year":"2024","journal-title":"Neuron"},{"issue":"11","key":"pone.0323230.ref008","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years","volume":"70","author":"H Braak","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"pone.0323230.ref009","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nn.3606","article-title":"Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer\u2019s disease","volume":"17","author":"UA Khan","year":"2014","journal-title":"Nat Neurosci"},{"issue":"1","key":"pone.0323230.ref010","article-title":"Anterolateral entorhinal cortex thickness as a new biomarker for early detection of Alzheimer\u2019s disease","volume":"12","author":"AJ Holbrook","year":"2020","journal-title":"Alzheimers Dement (Amst)"},{"key":"pone.0323230.ref011","doi-asserted-by":"crossref","first-page":"13169","DOI":"10.3389\/bjbs.2024.13169","article-title":"Neuronal Vulnerability of the Entorhinal Cortex to Tau Pathology in Alzheimer\u2019s Disease","volume":"81","author":"S Zhang","year":"2024","journal-title":"Br J Biomed Sci"},{"issue":"1","key":"pone.0323230.ref012","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1038\/s41467-025-60370-8","article-title":"Variable and interactive effects of Sex, APOE \u03b54 and TREM2 on the deposition of tau in entorhinal and neocortical regions","volume":"16","author":"J Giorgio","year":"2025","journal-title":"Nat Commun"},{"key":"pone.0323230.ref013","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neurobiolaging.2021.04.003","article-title":"Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer\u2019s continuum: greater tau-PET retention in females","volume":"105","author":"L Edwards","year":"2021","journal-title":"Neurobiol Aging"},{"issue":"5","key":"pone.0323230.ref014","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/ana.25878","article-title":"Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline","volume":"88","author":"RF Buckley","year":"2020","journal-title":"Ann Neurol"},{"issue":"5","key":"pone.0323230.ref015","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/jamaneurol.2018.4693","article-title":"Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults","volume":"76","author":"RF Buckley","year":"2019","journal-title":"JAMA Neurol"},{"issue":"12","key":"pone.0323230.ref016","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1093\/brain\/awaa327","article-title":"The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects","volume":"143","author":"R Smith","year":"2020","journal-title":"Brain"},{"key":"pone.0323230.ref017","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0306-4522(89)90424-7","article-title":"The three-dimensional organization of the hippocampal formation: a review of anatomical data","volume":"31","author":"DG Amaral","year":"1989","journal-title":"Neuroscience"},{"issue":"14","key":"pone.0323230.ref018","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996","article-title":"Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer\u2019s disease","volume":"16","author":"T G\u00f3mez-Isla","year":"1996","journal-title":"J Neurosci"},{"issue":"2","key":"pone.0323230.ref019","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1531-8249(20010201)49:2<202::AID-ANA40>3.0.CO;2-3","article-title":"Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment","volume":"49","author":"JH Kordower","year":"2001","journal-title":"Ann Neurol"},{"issue":"28","key":"pone.0323230.ref020","doi-asserted-by":"crossref","first-page":"12687","DOI":"10.1073\/pnas.1002113107","article-title":"Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo","volume":"107","author":"MA Yassa","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"pone.0323230.ref021","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1073\/pnas.1101567108","article-title":"Age-related memory deficits linked to circuit-specific disruptions in the hippocampus","volume":"108","author":"MA Yassa","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0323230.ref022","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.nlm.2015.06.014","article-title":"Mnemonic discrimination relates to perforant path integrity: An ultra-high resolution diffusion tensor imaging study","volume":"129","author":"IJ Bennett","year":"2016","journal-title":"Neurobiol Learn Mem"},{"issue":"5594","key":"pone.0323230.ref023","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer\u2019s disease is a synaptic failure","volume":"298","author":"DJ Selkoe","year":"2002","journal-title":"Science"},{"issue":"1","key":"pone.0323230.ref024","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41582-022-00749-z","article-title":"Synaptic degeneration in Alzheimer disease","volume":"19","author":"M Tzioras","year":"2023","journal-title":"Nat Rev Neurol"},{"issue":"4","key":"pone.0323230.ref025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1006\/neur.1996.0056","article-title":"Structural correlates of cognition in dementia: quantification and assessment of synapse change","volume":"5","author":"ST DeKosky","year":"1996","journal-title":"Neurodegeneration"},{"issue":"4667","key":"pone.0323230.ref026","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.6474172","article-title":"Alzheimer\u2019s disease: cell-specific pathology isolates the hippocampal formation","volume":"225","author":"BT Hyman","year":"1984","journal-title":"Science"},{"issue":"1635","key":"pone.0323230.ref027","doi-asserted-by":"crossref","first-page":"20130369","DOI":"10.1098\/rstb.2013.0369","article-title":"Functional correlates of the lateral and medial entorhinal cortex: objects, path integration and local-global reference frames","volume":"369","author":"JJ Knierim","year":"2013","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"7","key":"pone.0323230.ref028","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.neubiorev.2011.07.006","article-title":"Towards a functional organization of episodic memory in the medial temporal lobe","volume":"36","author":"H Eichenbaum","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"pone.0323230.ref029","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06426","article-title":"Functional subregions of the human entorhinal cortex","volume":"4","author":"A Maass","year":"2015","journal-title":"Elife"},{"key":"pone.0323230.ref030","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06738","article-title":"Functional topography of the human entorhinal cortex","volume":"4","author":"T Navarro Schr\u00f6der","year":"2015","journal-title":"Elife"},{"key":"pone.0323230.ref031","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49132","article-title":"Cortical tau deposition follows patterns of entorhinal functional connectivity in aging","volume":"8","author":"JN Adams","year":"2019","journal-title":"Elife"},{"key":"pone.0323230.ref032","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.neuron.2018.01.039","article-title":"Functional Imbalance of Anterolateral Entorhinal Cortex and Hippocampal Dentate\/CA3 Underlies Age-Related Object Pattern Separation Deficits","volume":"97","author":"ZM Reagh","year":"2018","journal-title":"Neuron"},{"key":"pone.0323230.ref033","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neurobiolaging.2017.04.025","article-title":"Human anterolateral entorhinal cortex volumes are associated with cognitive decline in aging prior to clinical diagnosis","volume":"57","author":"RK Olsen","year":"2017","journal-title":"Neurobiol Aging"},{"issue":"12","key":"pone.0323230.ref034","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/hipo.22658","article-title":"Early cognitive decline in older adults better predicts object than scene recognition performance","volume":"26","author":"CO Fidalgo","year":"2016","journal-title":"Hippocampus"},{"issue":"5","key":"pone.0323230.ref035","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1162\/jocn_a_01385","article-title":"Object-in-place Memory Predicted by Anterolateral Entorhinal Cortex and Parahippocampal Cortex Volume in Older Adults","volume":"31","author":"L-K Yeung","year":"2019","journal-title":"J Cogn Neurosci"},{"issue":"10","key":"pone.0323230.ref036","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1523\/JNEUROSCI.2376-20.2021","article-title":"Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus","volume":"41","author":"M Amani","year":"2021","journal-title":"J Neurosci"},{"issue":"3","key":"pone.0323230.ref037","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tins.2018.12.001","article-title":"Recalibrating the Relevance of Adult Neurogenesis","volume":"42","author":"JS Snyder","year":"2019","journal-title":"Trends Neurosci"},{"issue":"6","key":"pone.0323230.ref038","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1152\/jn.2001.85.6.2423","article-title":"Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus","volume":"85","author":"JS Snyder","year":"2001","journal-title":"J Neurophysiol"},{"issue":"6988","key":"pone.0323230.ref039","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature02553","article-title":"Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus","volume":"429","author":"C Schmidt-Hieber","year":"2004","journal-title":"Nature"},{"issue":"4","key":"pone.0323230.ref040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.neuron.2007.05.002","article-title":"A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain","volume":"54","author":"S Ge","year":"2007","journal-title":"Neuron"},{"issue":"12","key":"pone.0323230.ref041","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/nn.3260","article-title":"Optical controlling reveals time-dependent roles for adult-born dentate granule cells","volume":"15","author":"Y Gu","year":"2012","journal-title":"Nat Neurosci"},{"issue":"4","key":"pone.0323230.ref042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005320","article-title":"Reliable activation of immature neurons in the adult hippocampus","volume":"4","author":"LA Mongiat","year":"2009","journal-title":"PLoS One"},{"issue":"30","key":"pone.0323230.ref043","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1523\/JNEUROSCI.1665-19.2020","article-title":"Adult-Born Hippocampal Neurons Undergo Extended Development and Are Morphologically Distinct from Neonatally-Born Neurons","volume":"40","author":"JD Cole","year":"2020","journal-title":"J Neurosci"},{"key":"pone.0323230.ref044","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ncomms2101","article-title":"Monosynaptic inputs to new neurons in the dentate gyrus","volume":"3","author":"C Vivar","year":"2012","journal-title":"Nat Commun"},{"issue":"26","key":"pone.0323230.ref045","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1523\/JNEUROSCI.1737-17.2018","article-title":"Preferential Targeting of Lateral Entorhinal Inputs onto Newly Integrated Granule Cells","volume":"38","author":"NI Woods","year":"2018","journal-title":"J Neurosci"},{"issue":"6","key":"pone.0323230.ref046","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0253642","article-title":"Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons","volume":"16","author":"NP Vyleta","year":"2021","journal-title":"PLoS One"},{"issue":"13","key":"pone.0323230.ref047","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1073\/pnas.0600948103","article-title":"Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer\u2019s disease","volume":"103","author":"JS Jacobsen","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"18","key":"pone.0323230.ref048","doi-asserted-by":"crossref","first-page":"7141","DOI":"10.1073\/pnas.0402147101","article-title":"Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses","volume":"101","author":"C-C Wu","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"pone.0323230.ref049","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1073\/pnas.242746599","article-title":"Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis","volume":"100","author":"JM Redwine","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"pone.0323230.ref050","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"S Oddo","year":"2003","journal-title":"Neuron"},{"key":"pone.0323230.ref051","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.nbd.2017.08.015","article-title":"Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit","volume":"108","author":"SL Angulo","year":"2017","journal-title":"Neurobiol Dis"},{"issue":"2","key":"pone.0323230.ref052","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neuron.2006.03.035","article-title":"CaMKII activation in the entorhinal cortex disrupts previously encoded spatial memory","volume":"50","author":"M Yasuda","year":"2006","journal-title":"Neuron"},{"issue":"4","key":"pone.0323230.ref053","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.neuron.2011.11.033","article-title":"Propagation of tau pathology in a model of early Alzheimer\u2019s disease","volume":"73","author":"A de Calignon","year":"2012","journal-title":"Neuron"},{"key":"pone.0323230.ref054","article-title":"Trans-synaptic spread of tau pathology in vivo","volume":"7","author":"L Liu","year":"2012","journal-title":"PLoS ONE"},{"issue":"33","key":"pone.0323230.ref055","doi-asserted-by":"crossref","first-page":"13300","DOI":"10.1523\/JNEUROSCI.0881-13.2013","article-title":"Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer\u2019s disease","volume":"33","author":"M Polydoro","year":"2013","journal-title":"J Neurosci"},{"issue":"6","key":"pone.0323230.ref056","doi-asserted-by":"crossref","DOI":"10.1002\/syn.21965","article-title":"Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer\u2019s disease","volume":"71","author":"EK Pickett","year":"2017","journal-title":"Synapse"},{"issue":"4","key":"pone.0323230.ref057","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1007\/s00429-015-1040-9","article-title":"Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex","volume":"221","author":"MJ Yetman","year":"2016","journal-title":"Brain Struct Funct"},{"issue":"3","key":"pone.0323230.ref058","article-title":"Ascl1 (Mash1) defines cells with long-term neurogenic potential in subgranular and subventricular zones in adult mouse brain","volume":"6","author":"EJ Kim","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"pone.0323230.ref059","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"L Madisen","year":"2010","journal-title":"Nat Neurosci"},{"issue":"46","key":"pone.0323230.ref060","doi-asserted-by":"crossref","first-page":"15379","DOI":"10.1523\/JNEUROSCI.2345-15.2015","article-title":"Reliable Genetic Labeling of Adult-Born Dentate Granule Cells Using Ascl1 CreERT2 and Glast CreERT2 Murine Lines","volume":"35","author":"SM Yang","year":"2015","journal-title":"J Neurosci"},{"issue":"1","key":"pone.0323230.ref061","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s42003-023-04678-5","article-title":"Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice","volume":"6","author":"NP Vyleta","year":"2023","journal-title":"Commun Biol"},{"issue":"24","key":"pone.0323230.ref062","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2023.09.016","article-title":"Adult-born granule cells facilitate remapping of spatial and non-spatial representations in the dentate gyrus","volume":"111","author":"SN Tuncdemir","year":"2023","journal-title":"Neuron"},{"issue":"6376","key":"pone.0323230.ref063","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1126\/science.aao5056","article-title":"Live imaging of neurogenesis in the adult mouse hippocampus","volume":"359","author":"G-A Pilz","year":"2018","journal-title":"Science"},{"issue":"2","key":"pone.0323230.ref064","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41593-020-00759-4","article-title":"Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging","volume":"24","author":"S Bottes","year":"2021","journal-title":"Nat Neurosci"},{"key":"pone.0323230.ref065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4939-3271-9_7","article-title":"Small-Scale Recombinant Adeno-Associated Virus Purification","volume":"1382","author":"C Burger","year":"2016","journal-title":"Methods Mol Biol"},{"issue":"1","key":"pone.0323230.ref066","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s40478-021-01189-4","article-title":"Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer\u2019s disease","volume":"9","author":"JD Cherry","year":"2021","journal-title":"Acta Neuropathol Commun"},{"issue":"17","key":"pone.0323230.ref067","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1093\/bioinformatics\/btr390","article-title":"Simple Neurite Tracer: open source software for reconstruction, visualization and analysis of neuronal processes","volume":"27","author":"MH Longair","year":"2011","journal-title":"Bioinformatics"},{"issue":"4","key":"pone.0323230.ref068","first-page":"387","article-title":"Dendritic organization in the neurons of the visual and motor cortices of the cat","volume":"87","author":"DA Sholl","year":"1953","journal-title":"J Anat"},{"issue":"1","key":"pone.0323230.ref069","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2017.08.008","article-title":"Spine Dynamics: Are They All the Same?","volume":"96","author":"KP Berry","year":"2017","journal-title":"Neuron"},{"issue":"1","key":"pone.0323230.ref070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuron.2021.10.030","article-title":"Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research","volume":"110","author":"Z Yu","year":"2022","journal-title":"Neuron"},{"key":"pone.0323230.ref071","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jneumeth.2017.01.003","article-title":"Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models","volume":"279","author":"MD Wilson","year":"2017","journal-title":"J Neurosci Methods"},{"key":"pone.0323230.ref072","unstructured":"AG Z. adrigabzu\/sholl_analysis_in_R: AUC calculation and stats (1.1). In: Zenodo [Internet]. 2018. Available: https:\/\/doi.org\/10.5281\/zenodo.1158612"},{"issue":"1","key":"pone.0323230.ref073","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Y Wang","year":"2016","journal-title":"Nat Rev Neurosci"},{"issue":"10","key":"pone.0323230.ref074","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.bbadis.2009.12.008","article-title":"Neurogenesis in mouse models of Alzheimer\u2019s disease","volume":"1802","author":"TT Chuang","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"pone.0323230.ref075","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41591-019-0375-9","article-title":"Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease","volume":"25","author":"EP Moreno-Jim\u00e9nez","year":"2019","journal-title":"Nat Med"},{"issue":"12","key":"pone.0323230.ref076","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/s41398-017-0013-6","article-title":"Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons","volume":"7","author":"M Bol\u00f3s","year":"2017","journal-title":"Transl Psychiatry"},{"key":"pone.0323230.ref077","doi-asserted-by":"crossref","unstructured":"Pfeiffer T, Poll S, Bancelin S, Angibaud J, Inavalli VK, Keppler K, et al. Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo. eLife. 2018;7: 1\u201317. https:\/\/doi.org\/10.7554\/elife.34700.001","DOI":"10.7554\/eLife.34700"},{"issue":"5","key":"pone.0323230.ref078","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuron.2006.04.026","article-title":"Long-term rearrangements of hippocampal mossy fiber terminal connectivity in the adult regulated by experience","volume":"50","author":"I Galimberti","year":"2006","journal-title":"Neuron"},{"issue":"2","key":"pone.0323230.ref079","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/ejn.15891","article-title":"Intermittent theta burst transcranial magnetic stimulation induces hippocampal mossy fibre plasticity in male but not female mice","volume":"57","author":"TR Zhang","year":"2023","journal-title":"Eur J Neurosci"},{"issue":"5","key":"pone.0323230.ref080","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.neuron.2015.07.012","article-title":"Neural Population Evidence of Functional Heterogeneity along the CA3 Transverse Axis: Pattern Completion versus Pattern Separation","volume":"87","author":"H Lee","year":"2015","journal-title":"Neuron"},{"issue":"9","key":"pone.0323230.ref081","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1523\/JNEUROSCI.18-09-03386.1998","article-title":"GABAergic cells are the major postsynaptic targets of mossy fibers in the rat hippocampus","volume":"18","author":"L Acs\u00e1dy","year":"1998","journal-title":"J Neurosci"},{"issue":"7348","key":"pone.0323230.ref082","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature09946","article-title":"Learning-related feedforward inhibitory connectivity growth required for memory precision","volume":"473","author":"S Ruediger","year":"2011","journal-title":"Nature"},{"issue":"4","key":"pone.0323230.ref083","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nm.4491","article-title":"Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization","volume":"24","author":"N Guo","year":"2018","journal-title":"Nat Med"},{"issue":"2","key":"pone.0323230.ref084","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00401-013-1215-5","article-title":"Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer\u2019s disease model","volume":"127","author":"M Polydoro","year":"2014","journal-title":"Acta Neuropathol"},{"issue":"3","key":"pone.0323230.ref085","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuron.2017.02.047","article-title":"The Mechanisms and Functions of Synaptic Facilitation","volume":"94","author":"SL Jackman","year":"2017","journal-title":"Neuron"},{"key":"pone.0323230.ref086","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuroscience.2013.07.063","article-title":"Electrophysiological identification of medial and lateral perforant path inputs to the dentate gyrus","volume":"252","author":"RP Petersen","year":"2013","journal-title":"Neuroscience"},{"issue":"4","key":"pone.0323230.ref087","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0160-16.2016","article-title":"A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation","volume":"3","author":"W Wang","year":"2016","journal-title":"eNeuro"},{"issue":"4","key":"pone.0323230.ref088","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00001756-199401120-00003","article-title":"Differential regulation of paired-pulse plasticity following LTP in the dentate gyrus","volume":"5","author":"BR Christie","year":"1994","journal-title":"Neuroreport"},{"issue":"22","key":"pone.0323230.ref089","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1523\/JNEUROSCI.3664-16.2017","article-title":"Anterolateral Entorhinal Cortex Volume Predicted by Altered Intra-Item Configural Processing","volume":"37","author":"L-K Yeung","year":"2017","journal-title":"J Neurosci"},{"issue":"6","key":"pone.0323230.ref090","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00401-014-1349-0","article-title":"Primary age-related tauopathy (PART): a common pathology associated with human aging","volume":"128","author":"JF Crary","year":"2014","journal-title":"Acta Neuropathol"},{"issue":"5","key":"pone.0323230.ref091","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00401-015-1390-7","article-title":"PART is part of Alzheimer disease","volume":"129","author":"C Duyckaerts","year":"2015","journal-title":"Acta Neuropathol"},{"issue":"5","key":"pone.0323230.ref092","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2020.12.016","article-title":"Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation","volume":"109","author":"P Largo-Barrientos","year":"2021","journal-title":"Neuron"},{"issue":"12","key":"pone.0323230.ref093","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1002\/alz.12582","article-title":"Synaptic density and cognitive performance in Alzheimer\u2019s disease: A PET imaging study with [11 C]UCB-J","volume":"18","author":"AP Mecca","year":"2022","journal-title":"Alzheimers Dement"},{"issue":"3","key":"pone.0323230.ref094","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1523\/JNEUROSCI.1397-18.2018","article-title":"Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity","volume":"39","author":"W Huijbers","year":"2019","journal-title":"J Neurosci"},{"key":"pone.0323230.ref095","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neurobiolaging.2021.11.004","article-title":"Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer\u2019s disease","volume":"111","author":"AP Mecca","year":"2022","journal-title":"Neurobiol Aging"},{"issue":"29","key":"pone.0323230.ref096","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.1523\/JNEUROSCI.2724-18.2019","article-title":"Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia","volume":"39","author":"J Terreros-Roncal","year":"2019","journal-title":"J Neurosci"},{"issue":"4","key":"pone.0323230.ref097","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2018.01.022","article-title":"Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau","volume":"97","author":"J McInnes","year":"2018","journal-title":"Neuron"},{"issue":"13","key":"pone.0323230.ref098","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1016\/j.celrep.2017.03.013","article-title":"Altered Synapse Stability in the Early Stages of Tauopathy","volume":"18","author":"JS Jackson","year":"2017","journal-title":"Cell Rep"},{"issue":"2","key":"pone.0323230.ref099","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.expneurol.2009.07.029","article-title":"Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs","volume":"223","author":"AB Rocher","year":"2010","journal-title":"Exp Neurol"},{"issue":"26","key":"pone.0323230.ref100","doi-asserted-by":"crossref","first-page":"15512","DOI":"10.1073\/pnas.93.26.15512","article-title":"Progressive entorhinal cortex lesions accelerate hippocampal sprouting and spare spatial memory in rats","volume":"93","author":"JJ Ramirez","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4730","key":"pone.0323230.ref101","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1126\/science.4071042","article-title":"Plasticity of hippocampal circuitry in Alzheimer\u2019s disease","volume":"230","author":"JW Geddes","year":"1985","journal-title":"Science"},{"key":"pone.0323230.ref102","doi-asserted-by":"crossref","first-page":"42370","DOI":"10.1038\/srep42370","article-title":"Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer\u2019s disease mouse model","volume":"7","author":"C Criscuolo","year":"2017","journal-title":"Sci Rep"},{"issue":"32","key":"pone.0323230.ref103","doi-asserted-by":"crossref","first-page":"11346","DOI":"10.1523\/JNEUROSCI.5289-14.2015","article-title":"Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer\u2019s Disease","volume":"35","author":"A Megill","year":"2015","journal-title":"J Neurosci"},{"issue":"36","key":"pone.0323230.ref104","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.0403678101","article-title":"Enhanced neurogenesis in Alzheimer\u2019s disease transgenic (PDGF-APPSw,Ind) mice","volume":"101","author":"K Jin","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pone.0323230.ref105","article-title":"Oral and Injected Tamoxifen Alter Adult Hippocampal Neurogenesis in Female and Male Mice","volume":"9","author":"BM Smith","year":"2022","journal-title":"eNeuro"},{"issue":"32","key":"pone.0323230.ref106","doi-asserted-by":"crossref","first-page":"19578","DOI":"10.1073\/pnas.1918883117","article-title":"Single-cell RNA-seq analysis revealed long-lasting adverse effects of tamoxifen on neurogenesis in prenatal and adult brains","volume":"117","author":"C-M Lee","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0323230.ref107","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnins.2017.00027","article-title":"Tamoxifen Activation of Cre-Recombinase Has No Persisting Effects on Adult Neurogenesis or Learning and Anxiety","volume":"11","author":"P Rotheneichner","year":"2017","journal-title":"Front Neurosci"},{"issue":"7","key":"pone.0323230.ref108","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/glia.24526","article-title":"Tamoxifen exerts direct and microglia-mediated effects preventing neuroinflammatory changes in the adult mouse hippocampal neurogenic niche","volume":"72","author":"I Crisci","year":"2024","journal-title":"Glia"},{"key":"pone.0323230.ref109","doi-asserted-by":"crossref","first-page":"104566","DOI":"10.1016\/j.neuint.2019.104566","article-title":"Tamoxifen promotes white matter recovery and cognitive functions in male mice after chronic hypoperfusion","volume":"131","author":"Y Chen","year":"2019","journal-title":"Neurochem Int"},{"issue":"11","key":"pone.0323230.ref110","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"H Asai","year":"2015","journal-title":"Nat Neurosci"},{"issue":"29","key":"pone.0323230.ref111","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1523\/JNEUROSCI.1744-05.2005","article-title":"Age-associated alterations of hippocampal place cells are subregion specific","volume":"25","author":"IA Wilson","year":"2005","journal-title":"J Neurosci"},{"issue":"3","key":"pone.0323230.ref112","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment","volume":"74","author":"A Bakker","year":"2012","journal-title":"Neuron"},{"issue":"6","key":"pone.0323230.ref113","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/hipo.22557","article-title":"Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons","volume":"26","author":"LJ Drew","year":"2016","journal-title":"Hippocampus"},{"key":"pone.0323230.ref114","doi-asserted-by":"crossref","first-page":"107710","DOI":"10.1016\/j.nlm.2022.107710","article-title":"Adult-born neurons inhibit developmentally-born neurons during spatial learning","volume":"198","author":"AM Ash","year":"2023","journal-title":"Neurobiol Learn Mem"},{"issue":"11","key":"pone.0323230.ref115","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/s41593-022-01176-5","article-title":"Adult-born dentate granule cells promote hippocampal population sparsity","volume":"25","author":"SB McHugh","year":"2022","journal-title":"Nat Neurosci"},{"issue":"9","key":"pone.0323230.ref116","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/hipo.22013","article-title":"Adult-born hippocampal neurons promote cognitive flexibility in mice","volume":"22","author":"NS Burghardt","year":"2012","journal-title":"Hippocampus"},{"issue":"29","key":"pone.0323230.ref117","doi-asserted-by":"crossref","first-page":"10600","DOI":"10.1523\/JNEUROSCI.3238-14.2015","article-title":"Development of Adult-Generated Cell Connectivity with Excitatory and Inhibitory Cell Populations in the Hippocampus","volume":"35","author":"L Restivo","year":"2015","journal-title":"J Neurosci"},{"issue":"8","key":"pone.0323230.ref118","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/hipo.23062","article-title":"Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures","volume":"29","author":"S Jain","year":"2019","journal-title":"Hippocampus"},{"issue":"4","key":"pone.0323230.ref119","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/hipo.22562","article-title":"Greater loss of object than spatial mnemonic discrimination in aged adults","volume":"26","author":"ZM Reagh","year":"2016","journal-title":"Hippocampus"},{"issue":"5","key":"pone.0323230.ref120","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/hipo.22097","article-title":"The medial and lateral entorhinal cortex both contribute to contextual and item recognition memory: a test of the binding of items and context model","volume":"23","author":"MR Hunsaker","year":"2013","journal-title":"Hippocampus"},{"issue":"1","key":"pone.0323230.ref121","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2019.11.027","article-title":"Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory","volume":"30","author":"B Vandrey","year":"2020","journal-title":"Curr Biol"},{"issue":"5","key":"pone.0323230.ref122","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/hipo.22095","article-title":"Lateral entorhinal cortex is critical for novel object-context recognition","volume":"23","author":"DIG Wilson","year":"2013","journal-title":"Hippocampus"},{"issue":"5937","key":"pone.0323230.ref123","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1173215","article-title":"A functional role for adult hippocampal neurogenesis in spatial pattern separation","volume":"325","author":"CD Clelland","year":"2009","journal-title":"Science"},{"issue":"3","key":"pone.0323230.ref124","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.celrep.2013.09.027","article-title":"BDNF in the dentate gyrus is required for consolidation of \u201cpattern-separated\u201d memories","volume":"5","author":"P Bekinschtein","year":"2013","journal-title":"Cell Rep"},{"issue":"1","key":"pone.0323230.ref125","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11682-016-9523-8","article-title":"Sex differences in the association between AD biomarkers and cognitive decline","volume":"11","author":"MEI Koran","year":"2017","journal-title":"Brain Imaging Behav"},{"issue":"7","key":"pone.0323230.ref126","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/nan.12729","article-title":"Sex differences in the neuropathological hallmarks of Alzheimer\u2019s disease: focus on cognitively intact elderly individuals","volume":"47","author":"Y-T Hu","year":"2021","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"9","key":"pone.0323230.ref127","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1002\/alz.13037","article-title":"Sexually dimorphic age-related molecular differences in the entorhinal cortex of cognitively intact elderly: Relation to early Alzheimer\u2019s changes","volume":"19","author":"X-L Chen","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"1","key":"pone.0323230.ref128","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12974-020-01749-w","article-title":"The behavioural and neuropathologic sexual dimorphism and absence of MIP-3\u03b1 in tau P301S mouse model of Alzheimer\u2019s disease","volume":"17","author":"Y Sun","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"3","key":"pone.0323230.ref129","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0054-22.2022","article-title":"Sex Differences in the Spatial Behavior Functions of Adult-Born Neurons in Rats","volume":"9","author":"TP O\u2019Leary","year":"2022","journal-title":"eNeuro"},{"issue":"5","key":"pone.0323230.ref130","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s12264-018-0268-9","article-title":"Sex Differences in Neuropathology and Cognitive Behavior in APP\/PS1\/tau Triple-Transgenic Mouse Model of Alzheimer\u2019s Disease","volume":"34","author":"J-T Yang","year":"2018","journal-title":"Neurosci Bull"},{"issue":"1","key":"pone.0323230.ref131","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13195-024-01492-x","article-title":"Age, sex and Alzheimer\u2019s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer\u2019s patients","volume":"16","author":"AJ Barber","year":"2024","journal-title":"Alzheimers Res Ther"},{"issue":"5534","key":"pone.0323230.ref132","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1126\/science.1058189","article-title":"Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP","volume":"293","author":"J Lewis","year":"2001","journal-title":"Science"},{"issue":"1","key":"pone.0323230.ref133","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13195-025-01684-z","article-title":"Sex differences in the association of Alzheimer\u2019s disease biomarkers and cognition in a multicenter memory clinic study","volume":"17","author":"C Boccalini","year":"2025","journal-title":"Alzheimers Res Ther"},{"issue":"6","key":"pone.0323230.ref134","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nn1908","article-title":"Synapse formation on neurons born in the adult hippocampus","volume":"10","author":"N Toni","year":"2007","journal-title":"Nat Neurosci"},{"issue":"8","key":"pone.0323230.ref135","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nn.2156","article-title":"Neurons born in the adult dentate gyrus form functional synapses with target cells","volume":"11","author":"N Toni","year":"2008","journal-title":"Nat Neurosci"},{"key":"pone.0323230.ref136","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19886","article-title":"Adult-born neurons modify excitatory synaptic transmission to existing neurons","volume":"6","author":"EW Adlaf","year":"2017","journal-title":"Elife"},{"issue":"6","key":"pone.0323230.ref137","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.neuron.2016.08.009","article-title":"Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits","volume":"91","author":"KM McAvoy","year":"2016","journal-title":"Neuron"},{"issue":"4","key":"pone.0323230.ref138","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/cne.10675","article-title":"Short-term and long-term survival of new neurons in the rat dentate gyrus","volume":"460","author":"AG Dayer","year":"2003","journal-title":"J Comp Neurol"},{"issue":"10","key":"pone.0323230.ref139","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1435","article-title":"Dentate gyrus neurons that are born at the peak of development, but not before or after, die in adulthood","volume":"9","author":"T Ciric","year":"2019","journal-title":"Brain Behav"},{"issue":"11","key":"pone.0323230.ref140","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/hipo.22760","article-title":"Early survival and delayed death of developmentally-born dentate gyrus neurons","volume":"27","author":"SP Cahill","year":"2017","journal-title":"Hippocampus"},{"issue":"8","key":"pone.0323230.ref141","article-title":"Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging","volume":"19","author":"M-F Montaron","year":"2020","journal-title":"Aging Cell"},{"issue":"9","key":"pone.0323230.ref142","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1523\/JNEUROSCI.4731-11.2012","article-title":"Long-lasting plasticity of hippocampal adult-born neurons","volume":"32","author":"V Lemaire","year":"2012","journal-title":"J Neurosci"},{"issue":"17","key":"pone.0323230.ref143","doi-asserted-by":"crossref","first-page":"7963","DOI":"10.1073\/pnas.0914613107","article-title":"Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons","volume":"107","author":"S Tronel","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"pone.0323230.ref144","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1523\/JNEUROSCI.4111-05.2006","article-title":"Delayed development of adult-generated granule cells in dentate gyrus","volume":"26","author":"LS Overstreet-Wadiche","year":"2006","journal-title":"J Neurosci"},{"issue":"5","key":"pone.0323230.ref145","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.celrep.2017.09.064","article-title":"High Plasticity of New Granule Cells in the Aging Hippocampus","volume":"21","author":"MF Trinchero","year":"2017","journal-title":"Cell Rep"},{"issue":"25","key":"pone.0323230.ref146","doi-asserted-by":"crossref","first-page":"10326","DOI":"10.1073\/pnas.1017099108","article-title":"Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months","volume":"108","author":"SJ Kohler","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pone.0323230.ref147","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0006-8993(85)91018-2","article-title":"Age-related dendritic growth in dentate gyrus of human brain is followed by regression in the \u201coldest old\u201d","volume":"345","author":"DG Flood","year":"1985","journal-title":"Brain Res"},{"issue":"2","key":"pone.0323230.ref148","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(87)90027-8","article-title":"Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia","volume":"402","author":"DG Flood","year":"1987","journal-title":"Brain Res"},{"issue":"7919","key":"pone.0323230.ref149","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-022-04912-w","article-title":"Molecular landscapes of human hippocampal immature neurons across lifespan","volume":"607","author":"Y Zhou","year":"2022","journal-title":"Nature"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0323230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:33:11Z","timestamp":1765391591000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0323230"}},"subtitle":[],"editor":[{"given":"Efthimios M. C.","family":"Skoulakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":149,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0323230","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]}}}