{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:02:51Z","timestamp":1787022171028,"version":"build-2736575974"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008086","name":"Universit\u00c3\u00a9 Joseph Fourier","doi-asserted-by":"publisher","award":["AGIR 2012"],"award-info":[{"award-number":["AGIR 2012"]}],"id":[{"id":"10.13039\/501100008086","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centre Hospitalier Universitaire de Grenoble","award":["DRCI 2013"],"award-info":[{"award-number":["DRCI 2013"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to develop a generic questionnaire for use in routine clinical practice to identify barriers and levers to medication adherence, particularly for patients with chronic disease, in order to implement targeted interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>To generate items we conducted a narrative literature review and qualitatively analyzed semi-structured interviews of patients with chronic diseases (type 2 diabetes, chronic obstructive pulmonary disease and heart failure). Items were classified according to the five dimensions that influence medication adherence proposed by the WHO. Qualitative reduction of the number of items was conducted by a panel of experts. This long questionnaire was tested on ambulatory patients and analysis of responses enabled quantitative item reduction. Validation of the short questionnaire and stability over time was tested on an independent cohort of patients, and again 15 days later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 194 items extracted from the literature review (validated in several pathologies) and\/or from analysis of 45 interviews, spanned all five dimensions of medication adherence according to the WHO. The expert panel reduced the number of items to 62. The analysis of responses from 112 patients using factorial component analysis reduced the final questionnaire to 14 questions each scored on a 7-point Likert-type scale. A validated visual analogue scale (0\u2013100) was added to evaluate medication adherence in general. The final version was well accepted by patients and took 5\u201310 minutes to complete, with little missing data. In an independent community pharmacy population (n\u2009=\u200955) concordance of the results between day 0 and day 15 was acceptable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This generic questionnaire (initially developed in French) for the identification of barriers and levers to medication adherence in patients with chronic disease could help care teams to structure and propose help-with-adherence visits to their patients and personalize interventions to improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0323542","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:23:47Z","timestamp":1761240227000},"page":"e0323542","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a self-administered questionnaire to identify levers and barriers to adherence to medication regimens for chronic disease: The QUILAM project"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4237-4329","authenticated-orcid":true,"given":"Audrey","family":"Lehmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Meslot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-1626","authenticated-orcid":true,"given":"Matthieu","family":"Roustit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Didier","family":"Bardet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Gauchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Allenet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"pone.0323542.ref001","author":"L Riley","year":"2020"},{"issue":"9","key":"pone.0323542.ref002","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1097\/00005650-200209000-00009","article-title":"Patient adherence and medical treatment outcomes: a meta-analysis","volume":"40","author":"MR DiMatteo","year":"2002","journal-title":"Med Care"},{"issue":"2","key":"pone.0323542.ref003","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s10549-010-1132-4","article-title":"Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer","volume":"126","author":"DL Hershman","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"pone.0323542.ref004","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2261-6-48","article-title":"Adherence to cardioprotective medications and mortality among patients with diabetes and ischemic heart disease","volume":"6","author":"PM Ho","year":"2006","journal-title":"BMC Cardiovasc Disord"},{"issue":"2","key":"pone.0323542.ref005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/ehjcvp\/pvaa010","article-title":"Low adherence to statin treatment during the 1st year after an acute myocardial infarction is associated with increased 2nd-year mortality risk-an inverse probability of treatment weighted study on 54\u2009872 patients","volume":"7","author":"K Khalaf","year":"2021","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"4","key":"pone.0323542.ref006","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1592\/phco.28.4.437","article-title":"Comparison of drug adherence rates among patients with seven different medical conditions","volume":"28","author":"BA Briesacher","year":"2008","journal-title":"Pharmacotherapy"},{"key":"pone.0323542.ref007","author":"E Sabate","year":"2003"},{"key":"pone.0323542.ref008","volume-title":"Investing in medication adherence improves health outcomes and health system efficiency: Adherence to medicines for diabetes, hypertension, and hyperlipidaemia. 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