{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:11:21Z","timestamp":1793225481444,"version":"4.5.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec016\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>This study aims to examine the short-term axial shortening effects of orthokeratology (ortho-K) lenses and investigate their mechanical mechanisms.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec017\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We conducted a retrospective analysis on 80 myopic children, aged 8\u201318, who wore ortho-K lenses for one week. Axial lengths were measured pre- and post-treatment using AL-Scan Optical Biometer. We developed a finite element model of the eye using ABAQUS software to explore mechanical changes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec018\">\n<jats:title>Results<\/jats:title>\n<jats:p>A significant reduction in axial length was observed after one week of ortho-K lens wear, with an average decrease of 0.028\u2009\u00b1\u20090.032\u2009mm (P\u2009=\u20094.02 x 10<jats:sup>-11<\/jats:sup>). Approximately 82.5% of participants exhibited axial length reduction. The biomechanical model indicated that ortho-K lenses exerted forces altering the tension dynamics within the ocular structure, notably decreasing tension in the posterior ciliary muscle-lens complex. This differential change in tension may account for the mechanical basis of the observed short-term reduction in axial length.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec019\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Orthokeratology lenses induce a short-term shortening in axial length, likely due to mechanical changes in ocular tension dynamics. The finite element model suggests that these lenses decrease posterior ciliary-lens complex tension, leading to axial shortening. These findings enhance comprehension of the mechanical basis for myopia control via ortho-K treatment, highlighting potential avenues for further applied research in myopia management.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0323546","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T17:41:13Z","timestamp":1747071673000},"page":"e0323546","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of axial shortening induced by orthokeratology lenses and its mechanical mechanisms"],"prefix":"10.1371","volume":"20","author":[{"given":"Zhao-Yang","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-5167","authenticated-orcid":true,"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"issue":"1","key":"pone.0323546.ref001","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"PN Baird","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"11","key":"pone.0323546.ref002","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.ophtha.2021.04.032","article-title":"The Risks and Benefits of Myopia Control","volume":"128","author":"MA Bullimore","year":"2021","journal-title":"Ophthalmology"},{"issue":"5","key":"pone.0323546.ref003","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.62.5.6","article-title":"IMI Prevention of Myopia and Its Progression","volume":"62","author":"JB Jonas","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"pone.0323546.ref004","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41433-021-01805-6","article-title":"Myopia prediction: a systematic review","volume":"36","author":"X Han","year":"2022","journal-title":"Eye (Lond)"},{"issue":"2","key":"pone.0323546.ref005","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bjophthalmol-2021-319306","article-title":"Interventions recommended for myopia prevention and control among children and adolescents in China: a systematic review","volume":"107","author":"Z Zhu","year":"2023","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"pone.0323546.ref006","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/opo.13366","article-title":"High myopia: Reviews of myopia control strategies and myopia complications","volume":"44","author":"R Shah","year":"2024","journal-title":"Ophthalmic Physiol Opt"},{"issue":"5","key":"pone.0323546.ref007","doi-asserted-by":"crossref","first-page":"101875","DOI":"10.1016\/j.clae.2023.101875","article-title":"Efficacy of the Euclid orthokeratology lens in slowing axial elongation","volume":"46","author":"MA Bullimore","year":"2023","journal-title":"Cont Lens Anterior Eye"},{"issue":"1","key":"pone.0323546.ref008","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10792-024-03175-w","article-title":"Benefits and risks of orthokeratology treatment: a systematic review and meta-analysis","volume":"44","author":"L Sartor","year":"2024","journal-title":"Int Ophthalmol"},{"issue":"2","key":"pone.0323546.ref009","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/aos.16775","article-title":"Myopia control with orthokeratology lenses. 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