{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:41:11Z","timestamp":1780555271793,"version":"3.54.1"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec015\">\n<jats:title>Background<\/jats:title>\n<jats:p>To explore the safety and effectiveness of partial splenic embolization (PSE) in patients with hypersplenism and hepatocellular carcinoma (HCC) and to compare the efficacy of superselective and non-superselective embolization of splenic artery branches.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec016\">\n<jats:title>Procedure<\/jats:title>\n<jats:p>We retrospectively analyzed 64 patients with HCC who underwent PSE between August 2020 and December 2022. The patients were categorized into two groups based on different treatment plans: Group A (n=33) underwent superselective embolization and Group B (n=31) underwent non-superselective embolization of the splenic artery branches. The safety and effectiveness of the two methods were evaluated along with changes in peripheral blood cells [mainly white blood cells (WBC) and red blood cells (RBC)] and platelet (PLT) counts at different time points after PSE. Postoperative adverse events were also compared between the two groups,<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec017\">\n<jats:title>Results<\/jats:title>\n<jats:p>The technical success rate was 100% for both procedures. The PLT and WBC counts of the two groups significantly increased one week after PSE (P&lt;0.05), and there was no statistically significant difference in the RBC count changes. At follow-up (4, 16, and 24 weeks), the PLT and WBC counts remained consistent at levels which were significantly different from those before PSE (P&lt;0.05). However, the RBC counts were not significantly different (P&gt;0.05). An independent sample t-test was used to compare the differences in blood counts between the two groups at the same time point. There were no statistically significant differences in PLT, WBC, and RBC counts between Group A and Group B at any time point after PSE (P&gt;0.05). The incidence of fever and pain in Group B was significantly higher than that in Group A (P&lt;0.05),<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec018\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Partial splenic artery embolization is a safe and effective treatment option for hypersplenism. Both splenic artery branch superselective and non-superselective embolization strategies demonstrated comparable outcomes. However, superselective embolization exhibited a lower incidence of postprocedural complications than non-superselective embolization.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0323829","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T18:03:18Z","timestamp":1748455398000},"page":"e0323829","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of the efficacy of splenic artery superselective embolization in cirrhosis with hepatocellular carcinoma"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3562-0203","authenticated-orcid":true,"given":"Ke","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Tao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Tao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-nan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-jun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"issue":"4","key":"pone.0323829.ref001","doi-asserted-by":"crossref","first-page":"452","DOI":"10.21037\/hbsn-20-480","article-title":"2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights","volume":"9","author":"D-Y Xie","year":"2020","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"3","key":"pone.0323829.ref002","first-page":"273","article-title":"Clinical efficacy of partial splenic arterial embolization in treatment of hypersplenism in patients with HBV-related cirrhosis","volume":"28","author":"P Wan","year":"2020","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"3","key":"pone.0323829.ref003","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1024\/0040-5930\/a000383","article-title":"Hypersplenism","volume":"70","author":"R Jeker","year":"2013","journal-title":"Ther Umsch"},{"issue":"3","key":"pone.0323829.ref004","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","article-title":"BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update","volume":"76","author":"M Reig","year":"2022","journal-title":"J Hepatol"},{"issue":"28","key":"pone.0323829.ref005","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.2217\/fon-2017-0739","article-title":"Hypoxia and tumor angiogenesis in the era of hepatocellular carcinoma transarterial loco-regional treatments","volume":"14","author":"M Petrillo","year":"2018","journal-title":"Future Oncol"},{"issue":"9","key":"pone.0323829.ref006","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003311","article-title":"Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy","volume":"9","author":"DJ Pinato","year":"2021","journal-title":"J Immunother Cancer"},{"issue":"1","key":"pone.0323829.ref007","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1515\/med-2022-0479","article-title":"Repeated partial splenic artery embolization for hypersplenism improves platelet count","volume":"17","author":"Y 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Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP)","author":"GA Hawker","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"8","key":"pone.0323829.ref011","doi-asserted-by":"crossref","first-page":"3000605231190967","DOI":"10.1177\/03000605231190967","article-title":"Evaluation of splenic infarction ratio and platelet increase ratio after partial splenic artery embolization","volume":"51","author":"J Ueda","year":"2023","journal-title":"J Int Med Res"},{"issue":"43","key":"pone.0323829.ref012","doi-asserted-by":"crossref","first-page":"9623","DOI":"10.3748\/wjg.v22.i43.9623","article-title":"Outcomes of partial splenic embolization in patients with massive splenomegaly due to idiopathic portal hypertension","volume":"22","author":"O Ozturk","year":"2016","journal-title":"World J 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