{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T20:21:11Z","timestamp":1788034871479,"version":"build-2784847793"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec>\n<jats:title>Background and Aim<\/jats:title>\n<jats:p>Using cross-sectional data from the 2009-2018 National Health and Nutrition Examination Survey, the purpose of this study was to investigate the potential link between lipid accumulation product and gout\/hyperuricemia<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The data from 10,871 individuals who participated in the National Health and Nutrition Examination Survey spanning the years 2009\u20132018 were utilized for additional scrutiny. Participants self-reported gout and hyperuricemia as measured by laboratory test data, and other relevant variables and information for LAP were included. Multivariate logistic regression, restricted cubic spline and <jats:italic>p<\/jats:italic>-trend test were employed to determine the association between LAP and gout\/hyperuricemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The study included 10,871 adults. The prevalence of hyperuricemia and gout was 20.9% and 5.57%, respectively. Compared with the first quartile, the fourth quartile of lipid accumulation product was associated with a 271% higher risk of hyperuricemia (OR = 3.711, 95% CI 2.732\u20135.042, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in a fully adjusted model. A similar association was found between continuous increase in lipid accumulation product and hyperuricemia (OR = 2.441, 95%CI\u2009=\u20091.348\u20134.42, <jats:italic>p<\/jats:italic>\u2009=\u20090.005), with <jats:italic>p<\/jats:italic> trends showing both &lt; 0.001. The RCS model suggests a significant non-linear relationship between lipid accumulation product and the risk of gout\/hyperuricemia. There was an inverted U-shaped relationship between lipid accumulation product and gout\/hyperuricemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This study confirmed that lipid accumulation product has a high potential to predict the risk of gout\/hyperuricemia. These findings suggested that the adjustment of the degree of fat accumulation may be a potential way to prevent and control the onset of gout\/hyperuricemia.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0324139","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T17:54:33Z","timestamp":1747763673000},"page":"e0324139","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lipid accumulation product: A novel marker for gout and 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