{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T04:10:02Z","timestamp":1748491802771,"version":"3.41.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Social interaction has been shown to prolong lifespan and healthspan. For older adults living alone, social interaction largely comes from formal social participation, and thus depends on the sociability of the individual. This study aims to understand the effect of age on sociability, and the possible mechanisms behind the change. 196 German participants aged 20\u201377 (Mage\u2009=\u200937.9) completed a series of questionnaires as part of the Leipzig Study for Mind-Body-Emotion Interactions. Sociability was measured by a subscale of the Trait Emotional Intelligence Questionnaire (Short Form), and network-based statistics were performed on resting-state functional connectivity data to identify networks positively and negatively correlated with age. Mediation analysis was carried out between age and sociability, with both sets of edges as mediators. Overall, age correlated negatively with sociability. The brain network correlating positively with age correlated negatively with sociability, and vice versa for the network correlating negatively with. Both networks independently and completely mediated the age-sociability relationship. The limbic-insular and ventral attention-somatomotor connectivity featured prominently in the age-positive network, while the age-negative network is largely represented by subcortical-parietal and frontoparietal-default mode connections. Networks associated with brain aging can explain the negative relationship between age and sociability. Per Dunbar\u2019s social brain hypothesis, age-related disruption in intrinsic functional connectivity may impair socio-cognitive functions necessary for forming and maintaining relationships, thus causing a decrease in sociability. Psychoeducation of these changes that occur with natural aging could prove useful in the promotion of successful aging.<\/jats:p>","DOI":"10.1371\/journal.pone.0324277","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T17:23:29Z","timestamp":1748453009000},"page":"e0324277","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrinsic functional connectivity brain networks mediate effect of age on sociability"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9592-2758","authenticated-orcid":true,"given":"Yuet Ruh","family":"Dan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-3845","authenticated-orcid":true,"given":"Savannah K. 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Gracia-Tabuenca","year":"2020"},{"key":"pone.0324277.ref046","author":"R Core Team.","year":"2022"},{"issue":"5","key":"pone.0324277.ref047","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v059.i05","article-title":"mediation:RPackage for Causal Mediation Analysis","volume":"59","author":"D Tingley","year":"2014","journal-title":"J Stat Soft"},{"issue":"3","key":"pone.0324277.ref048","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"BTT Yeo","year":"2011","journal-title":"J Neurophysiol"},{"key":"pone.0324277.ref049","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.psych.58.110405.085542","article-title":"Mediation analysis","volume":"58","author":"DP MacKinnon","year":"2007","journal-title":"Annu Rev 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Jockwitz","year":"2021","journal-title":"Pflugers Arch"},{"issue":"7","key":"pone.0324277.ref056","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/cercor\/bhu012","article-title":"A Brain-Wide Study of Age-Related Changes in Functional Connectivity","volume":"25","author":"L Geerligs","year":"2015","journal-title":"Cereb Cortex"},{"issue":"1","key":"pone.0324277.ref057","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1162\/netn_a_00110","article-title":"Age-related differences in functional brain network segregation are consistent with a cascade of cerebrovascular, structural, and cognitive effects","volume":"4","author":"TS Kong","year":"2020","journal-title":"Netw Neurosci"},{"issue":"10","key":"pone.0324277.ref058","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1002\/hbm.25428","article-title":"Increased segregation of structural brain networks underpins enhanced broad cognitive abilities of cognitive training","volume":"42","author":"Q Chen","year":"2021","journal-title":"Hum Brain Mapp"},{"key":"pone.0324277.ref059","doi-asserted-by":"crossref","first-page":"118449","DOI":"10.1016\/j.neuroimage.2021.118449","article-title":"When functional blurring becomes deleterious: Reduced system segregation is associated with less white matter integrity and cognitive decline in aging","volume":"242","author":"R Pedersen","year":"2021","journal-title":"Neuroimage"},{"issue":"11","key":"pone.0324277.ref060","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/aur.2350","article-title":"The Role of Executive Functioning in Predicting Social Competence in Children with and without Autism Spectrum Disorder","volume":"13","author":"VC Fong","year":"2020","journal-title":"Autism Res"},{"issue":"5","key":"pone.0324277.ref061","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/03014460902960289","article-title":"The social brain hypothesis and its implications for social evolution","volume":"36","author":"RIM 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