{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:57:45Z","timestamp":1787061465612,"version":"build-2736575974"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 2610\/01"],"award-info":[{"award-number":["GRK 2610\/01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Retinitis pigmentosa (RP) is a leading cause of blindness. The best studied models of human RP are the\n                    <jats:italic>rd1<\/jats:italic>\n                    and\n                    <jats:italic>rd10<\/jats:italic>\n                    mouse and the\n                    <jats:italic>RCS<\/jats:italic>\n                    rat (\n                    <jats:italic>Royal College of Surgeons<\/jats:italic>\n                    ). In many models after degeneration of the photoreceptors, a pathological rhythmic activity of the retina as well as lowered efficiency of electrical stimulation were observed. In\n                    <jats:italic>rd10<\/jats:italic>\n                    retina, both events were shown to be intimately linked. Surprisingly, to our knowledge no retinal oscillations have been reported in\n                    <jats:italic>RCS<\/jats:italic>\n                    retina. As oscillations might interfere with the performance of therapeutic approaches to restore vision, e.g., retinal prostheses, it is important to know, whether they are a common feature of retinal degeneration. Electrical activity was recorded in retinae of 3\u201319 months (M3-19) old\n                    <jats:italic>RCS<\/jats:italic>\n                    rats\n                    <jats:italic>in vitro<\/jats:italic>\n                    using planar and penetrating multi-electrode-arrays. Short deflections in the local field potential resembling those observed in oscillations in\n                    <jats:italic>rd1<\/jats:italic>\n                    and\n                    <jats:italic>rd10<\/jats:italic>\n                    retinae were only sporadically found in M3\n                    <jats:italic>RCS<\/jats:italic>\n                    retinae. Oscillations at appr. 2 Hz occurred more often and were more pronounced the older the animals were. Yet, even at M18-19 oscillatory periods were short and separated by long periods of non-oscillatory activity. In summary, in advanced stages of degeneration,\n                    <jats:italic>RCS<\/jats:italic>\n                    retinae display oscillations similar to\n                    <jats:italic>rd1<\/jats:italic>\n                    and\n                    <jats:italic>rd10<\/jats:italic>\n                    retinae. However, in\n                    <jats:italic>RCS<\/jats:italic>\n                    retina oscillatory periods are shorter than in mouse models and may, therefore, have escaped detection in earlier studies. These results together with results observed in non-rodent models suggest that pathological rhythmic activity is a common feature in RP models.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0324345","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T14:13:06Z","timestamp":1748355186000},"page":"e0324345","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Late emergence of pathological oscillatory activity in the retina of the Retinitis pigmentosa model RCS (Royal College of Surgeons) rat"],"prefix":"10.1371","volume":"20","author":[{"name":"Nruthyathi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana Rinc\u00f3n","family":"Montes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Offenh\u00e4usser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Willuweit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-1227","authenticated-orcid":true,"given":"Frank","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"pone.0324345.ref001","doi-asserted-by":"crossref","first-page":"874751","DOI":"10.1155\/2014\/874751","article-title":"Correlations between ERG, OCT, and anatomical findings in the rd10 mouse","volume":"2014","author":"S R\u00f6sch","year":"2014","journal-title":"J 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