{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T18:23:55Z","timestamp":1775327035193,"version":"3.50.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI22C073600"],"award-info":[{"award-number":["HI22C073600"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2023-00262087"],"award-info":[{"award-number":["RS-2023-00262087"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018528","name":"Korean Neurological Association","doi-asserted-by":"publisher","award":["KNA-16-HS-03"],"award-info":[{"award-number":["KNA-16-HS-03"]}],"id":[{"id":"10.13039\/100018528","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Individuals with chronic kidney disease (CKD) are often diagnosed with dyslipidemia, contributing to their cardiovascular risk. However, the relationship between renal hyperfiltration (RHF) and dyslipidemia remains unclear. Here, we aimed to examine the association between RHF and incidence of dyslipidemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We examined the data of 2,780,874 participants who underwent health examinations between 2010 and 2011 from the Korean NHIS-HEALS database. Renal function was assessed using estimated glomerular filtration rate (eGFR) levels that were calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. The incidence of dyslipidemia was defined as the outcome. Dyslipidemia was characterized by meeting the following criteria: having at least one claim of International Classification of Diseases (ICD)-10 code (E78) with an anti-dyslipidemia agent prescription, claims of ICD-10 code (E78) occurring more than twice, a total cholesterol level\u2009\u2265\u2009240\u2009mg\/dL, low-density lipoprotein cholesterol\u2009\u2265\u2009160\u2009mg\/dL, triglycerides\u2009\u2265\u2009200\u2009mg\/dL, or high-density lipoprotein cholesterol\u2009&lt;\u200940\u2009mg\/dL. RHF was defined as having an eGFR\u2009&gt;\u2009120\u2009mL\/min\u2009\u2219\u20091.73 m<jats:sup>2<\/jats:sup> defined by the eGFR range or being in the 10<jats:sup>th<\/jats:sup> decile of whole eGFR level.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Over a median follow-up of 9.56 years, 2,243,502 participants with dyslipidemia were identified. The mean age of participants was 47.35\u2009\u00b1\u200913.96 years. In the multivariable Cox regression analysis, eGFR\u2009&gt;\u2009120\u2009mL\/min\u2009\u2219\u20091.73 m<jats:sup>2<\/jats:sup> was associated with a decreased risk of dyslipidemia (HR: 0.35; 95% CI [0.34\u20130.36]). Furthermore, compared to the fifth decile, tenth (\u2265 114.21) (HR: 0.47, 95% CI (0.46\u20130.48) eGFR deciles were significantly associated with a reduced incidence of dyslipidemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The general population with RHF may have a lower risk of incidence of dyslipidemia. The identified inverse association between RHF and dyslipidemia underscores its significance in risk stratification and preventive interventions in clinical practice.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0324710","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T20:03:44Z","timestamp":1748981024000},"page":"e0324710","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of renal hyperfiltration with incidence of dyslipidemia: a nationwide retrospective longitudinal cohort study"],"prefix":"10.1371","volume":"20","author":[{"given":"Hyungjong","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min 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