{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:25:12Z","timestamp":1790825112465,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Program Management Unit for Human Resources and Institutional Development, Research and Innovation (PMU-B) for postmaster scholarship"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Although <jats:italic>Schinus terebinthifolia<\/jats:italic> (commonly known as Brazilian peppertree) has been documented to possess various biological activities, such as anticancer, antibacterial, and antioxidant properties, its anti-influenza activity has not yet been documented. Here, an aqueous-ethanolic extract (30% v\/v ethanol solution), prepared from its aerial parts (leaves and stalks), was established to determine whether it is a rich source of antiviral agents. The hydroethanolic plant extract, with a TPC value of 264.11\u2009mg (GAE)\/g DE, exhibits a promising IC<jats:sub>50<\/jats:sub> value of 16.33 \u03bcg\/mL, similar to that of authentic quercetin (IC<jats:sub>50<\/jats:sub>\u2009=\u200912.72 \u03bcg\/mL), and approximately 5.34 times higher than that of gallic acid (IC<jats:sub>50<\/jats:sub>\u2009=\u20093.06 \u03bcg\/mL) as determined by the DPPH assay. This extract contains 1.71\u2009mg of gallic acid (representative marker) per gram of dried plant material, according to HPLC analysis. Using untargeted metabolomics analysis coupled with a series of cheminformatics tools (MetFrag, SIRIUS, CSI:FingerID, and CANOPUS), we ultimately proved that the <jats:italic>S. terebinthifolia<\/jats:italic> hydroethanolic extract contains simple phenolics (e.g., methyl gallate, ethyl gallate, and chlorogenic acid), flavonoids (afzelin and myricitrin), dicarboxylic acids, and germacrone. As anticipated, the plant extract exhibited anti-influenza activity with an IC<jats:sub>50<\/jats:sub> of 2.21 \u03bcg\/mL (CC<jats:sub>50<\/jats:sub>\u2009&gt;\u200950 \u03bcg\/mL) and did not exert hemolytic activity at the concentration of 2000 \u03bcg\/mL, underscoring its efficacy as a safe antiviral solution. <jats:italic>In silico<\/jats:italic> molecular docking and dynamic simulations suggest that neuraminidase and the cap-binding domain of influenza RNA polymerase (PB2) are preferentially targeted for inhibition by the detected metabolites. Owing to the diverse therapeutic effects of secondary metabolites, the anti-H5N1 activity of the newly developed plant extract is currently under investigation.<\/jats:p>","DOI":"10.1371\/journal.pone.0324990","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T17:31:29Z","timestamp":1748885489000},"page":"e0324990","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hydroethanolic extract of Schinus terebinthifolia as a promising source of anti-influenza agents: Phytochemical profiling, cheminformatics, molecular docking and dynamics simulations"],"prefix":"10.1371","volume":"20","author":[{"given":"Napapuch","family":"Nopkuesuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuwatchakij","family":"Klamrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaran","family":"Nabnueangsap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaraspim","family":"Narkpuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaikh Shahinur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutthakan","family":"Saengkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyapon","family":"Janpan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8133-6968","authenticated-orcid":true,"given":"Thananya","family":"Soonkum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poramet","family":"Sitthiwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2071-2406","authenticated-orcid":true,"given":"Nisachon","family":"Jangpromma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirinan","family":"Kulchat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiattawee","family":"Choowongkomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Patramanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunrat","family":"Chaveerach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaporn","family":"Teeravechyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jureerut","family":"Daduang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakda","family":"Daduang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"issue":"5","key":"pone.0324990.ref001","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.sjbs.2015.01.011","article-title":"Anti-influenza (H1N1) potential of leaf and stem bark extracts of selected medicinal plants of South India","volume":"22","author":"G Enkhtaivan","year":"2015","journal-title":"Saudi J Biol Sci"},{"issue":"11","key":"pone.0324990.ref002","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/aje\/kwu360","article-title":"Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009: a longitudinal study","volume":"181","author":"BS Cooper","year":"2015","journal-title":"Am J Epidemiol"},{"key":"pone.0324990.ref003","doi-asserted-by":"crossref","first-page":"100517","DOI":"10.1016\/j.jvacx.2024.100517","article-title":"Influenza virus circulation and vaccine effectiveness during June 2021-May 2023 in Thailand","volume":"19","author":"K Prasert","year":"2024","journal-title":"Vaccine X"},{"issue":"10","key":"pone.0324990.ref004","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3390\/foods10102277","article-title":"Antiviral Properties of Polyphenols from Plants","volume":"10","author":"K Chojnacka","year":"2021","journal-title":"Foods"},{"key":"pone.0324990.ref005","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fitote.2013.12.011","article-title":"Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure-activity relationship analysis","volume":"93","author":"Z-F Yang","year":"2014","journal-title":"Fitoterapia"},{"issue":"4","key":"pone.0324990.ref006","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/ptr.6575","article-title":"Antiviral activity of plants and their isolated bioactive compounds: An update","volume":"34","author":"M Denaro","year":"2020","journal-title":"Phytother Res"},{"key":"pone.0324990.ref007","first-page":"479718","article-title":"The Effectiveness and Mechanism of Toona sinensis Extract Inhibit Attachment of Pandemic Influenza A (H1N1) Virus","volume":"2013","author":"H-L You","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"pone.0324990.ref008","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbrc.2013.08.090","article-title":"Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses","volume":"440","author":"S Park","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0324990.ref009","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jff.2017.07.050","article-title":"Berries as a potential anti-influenza factor \u2013 A review","volume":"37","author":"A Gramza-Micha\u0142owska","year":"2017","journal-title":"Journal of Functional Foods"},{"issue":"1","key":"pone.0324990.ref010","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s43094-021-00269-5","article-title":"Substantial effect of phytochemical constituents against the pandemic disease influenza-a review","volume":"7","author":"AB Devi","year":"2021","journal-title":"Futur J Pharm Sci"},{"issue":"1","key":"pone.0324990.ref011","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/foods13010081","article-title":"Unveiling the Potent Antiviral and Antioxidant Activities of an Aqueous Extract from Caesalpinia mimosoides Lamk: Cheminformatics and Molecular Docking Approaches","volume":"13","author":"A Klamrak","year":"2023","journal-title":"Foods"},{"key":"pone.0324990.ref012","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.indcrop.2015.11.077","article-title":"Composition and biological activity of Brazilian rose pepper (Schinus terebinthifolius Raddi) leaves","volume":"83","author":"MP Uliana","year":"2016","journal-title":"Industrial Crops and Products"},{"key":"pone.0324990.ref013","first-page":"363","article-title":"Bioactive Compounds from Schinus terebinthifolius Raddi and Their Potential Health Benefits. Phytopharmaceuticals","volume":"3","author":"NB Macedo","year":"2021","journal-title":"Potential Therapeutic Applications"},{"issue":"6","key":"pone.0324990.ref014","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3390\/microorganisms8060859","article-title":"Diversity, Chemical Constituents and Biological Activities of Endophytic Fungi Isolated from Schinus terebinthifolius Raddi","volume":"8","author":"PDSd Rocha","year":"2020","journal-title":"Microorganisms"},{"issue":"1","key":"pone.0324990.ref015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.31482\/mmsl.2017.005","article-title":"Brazilian pepper tree: review of pharmacology","volume":"86","author":"J Pato\u010dka","year":"2017","journal-title":"Mil Med Sci Lett"},{"issue":"1","key":"pone.0324990.ref016","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1038\/s41598-025-87585-5","article-title":"Integrative computational analysis of anti-influenza potential in Caesalpinia mimosoides Lamk hydroethanolic extract","volume":"15","author":"A Klamrak","year":"2025","journal-title":"Sci Rep"},{"issue":"2","key":"pone.0324990.ref017","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/metabo8020031","article-title":"Software Tools and Approaches for Compound Identification of LC-MS\/MS Data in Metabolomics","volume":"8","author":"I Bla\u017eenovi\u0107","year":"2018","journal-title":"Metabolites"},{"key":"pone.0324990.ref018","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"A Daina","year":"2017","journal-title":"Sci Rep"},{"issue":"2","key":"pone.0324990.ref019","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0021-9258(18)84277-6","article-title":"On tyrosine and tryptophane determinations in proteins","volume":"73","author":"O Folin","year":"1927","journal-title":"J Biol Chem"},{"key":"pone.0324990.ref020","first-page":"107","author":"RM Lamuela-Ravent\u00f3s","year":"2017"},{"issue":"1","key":"pone.0324990.ref021","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ptr.7309","article-title":"Quercetin and its derivates as antiviral potentials: A comprehensive review","volume":"36","author":"A Di Petrillo","year":"2022","journal-title":"Phytother Res"},{"issue":"5","key":"pone.0324990.ref022","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jcma.2017.11.007","article-title":"Anti-pandemic influenza A (H1N1) virus potential of catechin and gallic acid","volume":"81","author":"H-L You","year":"2018","journal-title":"J Chin Med Assoc"},{"issue":"1","key":"pone.0324990.ref023","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/fft2.10","article-title":"Guidelines for antioxidant assays for food components","volume":"1","author":"F Xiao","year":"2020","journal-title":"Food Frontiers"},{"key":"pone.0324990.ref024","doi-asserted-by":"crossref","first-page":"112671","DOI":"10.1016\/j.jep.2020.112671","article-title":"Anti-influenza virus phytochemicals from Radix Paeoniae Alba and characterization of their neuraminidase inhibitory activities","volume":"253","author":"T Zhang","year":"2020","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"pone.0324990.ref025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)","volume":"3","author":"LW Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"pone.0324990.ref026","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-0716-0239-3_11","article-title":"De Novo Molecular Formula Annotation and Structure Elucidation Using SIRIUS 4","volume":"2104","author":"M Ludwig","year":"2020","journal-title":"Methods Mol Biol"},{"issue":"6","key":"pone.0324990.ref027","article-title":"Analysis of Cell Viability by the MTT Assay","volume":"2018","author":"P Kumar","year":"2018","journal-title":"Cold Spring Harb Protoc"},{"issue":"22","key":"pone.0324990.ref028","doi-asserted-by":"crossref","first-page":"20381","DOI":"10.1074\/jbc.M300130200","article-title":"Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding","volume":"278","author":"P Fechter","year":"2003","journal-title":"J Biol Chem"},{"issue":"3","key":"pone.0324990.ref029","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.antiviral.2013.09.021","article-title":"Germacrone inhibits early stages of influenza virus infection","volume":"100","author":"Q Liao","year":"2013","journal-title":"Antiviral Res"},{"issue":"3","key":"pone.0324990.ref030","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/fsn3.3852","article-title":"Anti-influenza A (H1N1) virus effect of gallic acid through inhibition of virulent protein production and association with autophagy","volume":"12","author":"C-C Chang","year":"2023","journal-title":"Food Sci Nutr"},{"key":"pone.0324990.ref031","doi-asserted-by":"crossref","first-page":"127508","DOI":"10.1016\/j.foodchem.2020.127508","article-title":"New insights into antiviral and cytotoxic potential of quercetin and its derivatives - A biochemical perspective","volume":"334","author":"E Gansukh","year":"2021","journal-title":"Food Chem"},{"issue":"2","key":"pone.0324990.ref032","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.virusres.2007.09.008","article-title":"Antiviral potentials of medicinal plants","volume":"131","author":"M Mukhtar","year":"2008","journal-title":"Virus Res"},{"issue":"4","key":"pone.0324990.ref033","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s13337-015-0276-6","article-title":"Herbal plants and plant preparations as remedial approach for viral diseases","volume":"26","author":"RK Ganjhu","year":"2015","journal-title":"Virusdisease"},{"issue":"1","key":"pone.0324990.ref034","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12870-021-02841-w","article-title":"Non-targeted and targeted metabolomics profiling of tea plants (Camellia sinensis) in response to its intercropping with Chinese chestnut","volume":"21","author":"T Wu","year":"2021","journal-title":"BMC Plant Biol"},{"issue":"5","key":"pone.0324990.ref035","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.bjp.2017.07.001","article-title":"Identification of phenolic compounds in Myricaria bracteata leaves by high-performance liquid chromatography with a diode array detector and liquid chromatography with tandem mass spectrometry","volume":"27","author":"AA Chernonosov","year":"2017","journal-title":"Revista Brasileira de Farmacognosia"},{"issue":"15","key":"pone.0324990.ref036","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.3390\/molecules27154779","article-title":"Metabolic Engineering of Shikimic Acid Biosynthesis Pathway for the Production of Shikimic Acid and Its Branched Products in Microorganisms: Advances and Prospects","volume":"27","author":"S Wu","year":"2022","journal-title":"Molecules"},{"key":"pone.0324990.ref037","doi-asserted-by":"crossref","DOI":"10.1371\/currents.RRN1052","article-title":"Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase","volume":"1","author":"T Kuzuhara","year":"2009","journal-title":"PLoS Curr"},{"issue":"6","key":"pone.0324990.ref038","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1021\/acs.joc.5b02828","article-title":"Mechanism of Rhodium-Catalyzed Formyl Activation: A Computational Study","volume":"81","author":"X Luo","year":"2016","journal-title":"J Org Chem"},{"issue":"1","key":"pone.0324990.ref039","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1039\/b100917f","article-title":"The chalcone synthase superfamily of type III polyketide synthases","volume":"20","author":"MB Austin","year":"2003","journal-title":"Nat Prod Rep"},{"issue":"1","key":"pone.0324990.ref040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/biom11010010","article-title":"Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus","volume":"11","author":"P Mehrbod","year":"2020","journal-title":"Biomolecules"},{"issue":"9","key":"pone.0324990.ref041","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.phymed.2016.06.001","article-title":"Probing the impact of quercetin-7-O-glucoside on influenza virus replication influence","volume":"23","author":"E Gansukh","year":"2016","journal-title":"Phytomedicine"},{"issue":"1","key":"pone.0324990.ref042","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/v8010006","article-title":"Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry","volume":"8","author":"W Wu","year":"2015","journal-title":"Viruses"},{"issue":"5","key":"pone.0324990.ref043","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1002\/ptr.7025","article-title":"Multiple modes of action of myricetin in influenza A virus infection","volume":"35","author":"H Sang","year":"2021","journal-title":"Phytother Res"},{"issue":"3","key":"pone.0324990.ref044","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.3390\/microbiolres14030069","article-title":"Natural Products from Red Algal Genus Laurencia as Potential Inhibitors of RdRp and nsp15 Enzymes of SARS-CoV-2: An In Silico Perspective","volume":"14","author":"O Pokharkar","year":"2023","journal-title":"Microbiology Research"},{"issue":"1","key":"pone.0324990.ref045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s43141-021-00120-7","article-title":"Molecular docking studies of some selected gallic acid derivatives against five non-structural proteins of novel coronavirus","volume":"19","author":"HI Umar","year":"2021","journal-title":"J Genet Eng Biotechnol"},{"issue":"6","key":"pone.0324990.ref046","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3390\/molecules23061295","article-title":"In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea","volume":"23","author":"K Saeki","year":"2018","journal-title":"Molecules"},{"key":"pone.0324990.ref047","doi-asserted-by":"crossref","first-page":"131528","DOI":"10.1016\/j.foodchem.2021.131528","article-title":"Bio-affinity ultra-filtration combined with HPLC-ESI-qTOF-MS\/MS for screening potential \u03b1-glucosidase inhibitors from Cerasus humilis (Bge.) Sok. leaf-tea and in silico analysis","volume":"373","author":"S Li","year":"2022","journal-title":"Food Chem"},{"issue":"1","key":"pone.0324990.ref048","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s12906-020-03139-4","article-title":"Inhibitory effect of Newtonia extracts and myricetin-3-o-rhamnoside (myricitrin) on bacterial biofilm formation","volume":"20","author":"KE Motlhatlego","year":"2020","journal-title":"BMC Complement Med Ther"},{"key":"pone.0324990.ref049","doi-asserted-by":"crossref","first-page":"199199","DOI":"10.1016\/j.virusres.2023.199199","article-title":"The antiviral activity of Thuja orientalis folium against Influenza A virus","volume":"335","author":"M-M Lee","year":"2023","journal-title":"Virus Res"},{"issue":"11","key":"pone.0324990.ref050","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.3390\/molecules26113402","article-title":"Decaffeination and Neuraminidase Inhibitory Activity of Arabica Green Coffee (Coffea arabica) Beans: Chlorogenic Acid as a Potential Bioactive Compound","volume":"26","author":"M Muchtaridi","year":"2021","journal-title":"Molecules"},{"issue":"2","key":"pone.0324990.ref051","doi-asserted-by":"crossref","DOI":"10.4172\/2329-6836.1000129","article-title":"Potential Anti-Influenza Virus Agents Based on Coffee Ingredients and Natural Flavonols","volume":"2","author":"K Kaihatsu","year":"2014","journal-title":"Nat Prod Chem Res"},{"issue":"5","key":"pone.0324990.ref052","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.14336\/AD.2021.0223","article-title":"Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells","volume":"12","author":"D Milenkovic","year":"2021","journal-title":"Aging Dis"},{"issue":"4","key":"pone.0324990.ref053","first-page":"285","article-title":"Anti-Influenza Virus Activity and Phenolic Content of Pomegranate (Punica granatum L.) Peel Extract and Fractions","volume":"11","author":"M-T Moradi","year":"2019","journal-title":"Avicenna J Med Biotechnol"},{"key":"pone.0324990.ref054","doi-asserted-by":"crossref","first-page":"45723","DOI":"10.1038\/srep45723","article-title":"Antiviral activity of chlorogenic acid against influenza A (H1N1\/H3N2) virus and its inhibition of neuraminidase","volume":"7","author":"Y Ding","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0324990.ref055","first-page":"128","article-title":"Computational study of the molecular mechanism of Lonicera japonica organic acids against influenza","volume":"1","author":"X Luo","year":"2016","journal-title":"Tradit Med Res"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0324990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T17:31:41Z","timestamp":1748885501000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0324990"}},"subtitle":[],"editor":[{"given":"A. H. M. Khurshid","family":"Alam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":55,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0324990","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,2]]}}}