{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:56:55Z","timestamp":1780491415479,"version":"3.54.1"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/200.454\/2023"],"award-info":[{"award-number":["E-26\/200.454\/2023"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["312305\/2022-2"],"award-info":[{"award-number":["312305\/2022-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["IOC-008-FIO-22-2-21"],"award-info":[{"award-number":["IOC-008-FIO-22-2-21"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Multiple strategies involving the parasite-host-vector triad are necessary to control <jats:italic>leishmania<\/jats:italic>sis. One option is to prevent or reduce transmission of the pathogen by the phlebotomine sand fly vectors. In this sense, it is essential to explore compounds that may influence the vectorial capacity of the insect and reduce its longevity. We investigated the effect of anti-<jats:italic>Leishmania<\/jats:italic> drugs administered via the sugar meal on longevity, blood feeding, oviposition, and parasite load on the third day of infection of the sand flies, to identify the most promising candidates for vector infection tests. We identified compounds that affected the longevity of sand flies (three pterocarpanquinones \u2013 LQB-475, LQB-181, and LQ-03; one hydroxyethylpiperazine, PMIC-4, and Pentamidine), reduced oviposition of females after blood feeding (LQB-181 and PMIC-4), but did not decrease infection rates or parasite loads. The results provide the effect of antiparasitic drugs from the perspective of the insect vector.<\/jats:p>","DOI":"10.1371\/journal.pone.0325178","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T17:53:52Z","timestamp":1750874032000},"page":"e0325178","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of sugar meal administered anti-Leishmania compounds on the vectorial capacity of the vector, Lutzomyia longipalpis"],"prefix":"10.1371","volume":"20","author":[{"given":"Tain\u00e1 Neves","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara Graciane Costa","family":"Latg\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeu Diniz","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6782-4440","authenticated-orcid":true,"given":"Felipe Cerqueira","family":"Demidoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed\u00e9zio Ferreira","family":"Cunha-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto Ribeiro","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Vin\u00edcius Nora","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Regina","family":"Brand\u00e3o Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viv Maureen","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaquip Daher","family":"Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Caio","family":"Torres Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod James","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"McDowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert Leonel","family":"de Matos Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-1116","authenticated-orcid":true,"given":"Fernando Ariel","family":"Genta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"pone.0325178.ref001","author":"World Health Organization","year":"2023"},{"key":"pone.0325178.ref002","volume-title":"Manual de Vigil\u00e2ncia e Controle da Leishmaniose Visceral","author":"Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica, Brasil","year":"2014"},{"key":"pone.0325178.ref003","volume-title":"Manual de vigil\u00e2ncia da leishmaniose tegumentar","author":"Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica, Departamento de Vigil\u00e2ncia das Doen\u00e7as Transmiss\u00edveis, Brasi","year":"2017"},{"key":"pone.0325178.ref004","author":"Pan American Health Organization","year":"2022"},{"issue":"5","key":"pone.0325178.ref005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"J Alvar","year":"2012","journal-title":"PLoS One"},{"key":"pone.0325178.ref006","author":"Organizaci\u00f3n Panamericana de la Salud","year":"2019"},{"key":"pone.0325178.ref007","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tmaid.2014.09.007","article-title":"Leishmaniasis in travelers: a literature review","volume":"12","author":"P Mansueto","year":"2014","journal-title":"Travel Med Infect Dis"},{"key":"pone.0325178.ref008","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-ento-120811-153557","article-title":"Biology of phlebotomine sand flies as vectors of disease agents","volume":"58","author":"PD Ready","year":"2013","journal-title":"Annu Rev Entomol"},{"key":"pone.0325178.ref009","first-page":"257","article-title":"Binomia.","volume-title":"Flebotom\u00edneos do Brasil","author":"RP Brazil","year":"2003"},{"key":"pone.0325178.ref010","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-3-319-75544-1_5","article-title":"Bionomy: Biology of Neotropical Phlebotomine Sand Flies.","volume-title":"Brazilian Sand Flies","author":"RP Brazil","year":"2018"},{"issue":"7","key":"pone.0325178.ref011","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1590\/0074-02760150207","article-title":"Lutzomyia longipalpis urbanisation and control","volume":"110","author":"OD Salom\u00f3n","year":"2015","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"3","key":"pone.0325178.ref012","article-title":"Lutzomyia longipalpis: an update on this sand fly vector","volume":"93","author":"FD R\u00eago","year":"2021","journal-title":"An Acad Bras Cienc"},{"issue":"3","key":"pone.0325178.ref013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004349","article-title":"A Historical Overview of the Classification, Evolution, and Dispersion of Leishmania Parasites and Sandflies","volume":"10","author":"M Akhoundi","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pone.0325178.ref014","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2915.2012.01034.x","article-title":"Phlebotomine sandflies and the spreading of leishmaniases and other diseases of public health concern","volume":"27","author":"M Maroli","year":"2013","journal-title":"Med Vet Entomol"},{"issue":"1","key":"pone.0325178.ref015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2915.1994.tb00381.x","article-title":"Sugars in the alimentary canal of Lutzomyia youngi (Diptera: phlebotominae)","volume":"8","author":"N A\u00f1ez","year":"1994","journal-title":"Med Vet Entomol"},{"key":"pone.0325178.ref016","doi-asserted-by":"crossref","first-page":"2472508","DOI":"10.1155\/2018\/2472508","article-title":"Second Blood Meal by Female Lutzomyia longipalpis: Enhancement by Oviposition and Its Effects on Digestion, Longevity, and Leishmania Infection","volume":"2018","author":"CS Moraes","year":"2018","journal-title":"Biomed Res Int"},{"issue":"7","key":"pone.0325178.ref017","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0169-4758(93)90070-V","article-title":"Leishmania and Sandflies: interactions in the life cycle and transmission","volume":"9","author":"Y Schlein","year":"1993","journal-title":"Parasitol Today"},{"issue":"1","key":"pone.0325178.ref018","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13071-017-2028-5","article-title":"The history of leishmaniasis","volume":"10","author":"D Steverding","year":"2017","journal-title":"Parasit Vectors"},{"issue":"1","key":"pone.0325178.ref019","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12936-021-03704-3","article-title":"Testing configurations of attractive toxic sugar bait (ATSB) stations in Mali, West Africa, for improving the control of malaria parasite transmission by vector mosquitoes and minimizing their effect on non-target insects","volume":"20","author":"RA Diarra","year":"2021","journal-title":"Malar J"},{"issue":"4","key":"pone.0325178.ref020","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/ijerph14040398","article-title":"Attractive Toxic Sugar Bait (ATSB) For Control of Mosquitoes and Its Impact on Non-Target Organisms: A Review","volume":"14","author":"JM Fiorenzano","year":"2017","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"pone.0325178.ref021","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12936-021-03684-4","article-title":"Estimating the potential impact of Attractive Targeted Sugar Baits (ATSBs) as a new vector control tool for Plasmodium falciparum malaria","volume":"20","author":"KJ Fraser","year":"2021","journal-title":"Malar J"},{"key":"pone.0325178.ref022","article-title":"Attraction of Phlebotomus papatasi to common fruit in the field","author":"A Junnila","year":"2011","journal-title":"J Vector Ecol"},{"key":"pone.0325178.ref023","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/978-3-319-75544-1_11","article-title":"Leishmaniasis-Vector Surveillance and Control in Brazil: A Challenge to Control Programs.","volume-title":"Brazilian Sand Flies","author":"ANS Maia-Elkhoury","year":"2018"},{"key":"pone.0325178.ref024","article-title":"Different methods of using attractive sugar baits (ATSB) for the control of Phlebotomus papatasi","author":"GC M\u00fcller","year":"2011","journal-title":"J Vector Ecol"},{"key":"pone.0325178.ref025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13071-015-0671-2","article-title":"Control of sand flies with attractive toxic sugar baits (ATSB) and potential impact on non-target organisms in Morocco","volume":"8","author":"WA Qualls","year":"2015","journal-title":"Parasit Vectors"},{"issue":"4","key":"pone.0325178.ref026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173558","article-title":"Control of zoonotic cutaneous leishmaniasis vector, Phlebotomus papatasi, using attractive toxic sugar baits (ATSB)","volume":"12","author":"A Saghafipour","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"pone.0325178.ref027","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1186\/s13071-018-3122-z","article-title":"Transmission blocking sugar baits for the control of Leishmania development inside sand flies using environmentally friendly beta-glycosides and their aglycones","volume":"11","author":"TN Ferreira","year":"2018","journal-title":"Parasit Vectors"},{"issue":"20","key":"pone.0325178.ref028","doi-asserted-by":"crossref","first-page":"9944","DOI":"10.1073\/pnas.89.20.9944","article-title":"Leishmania infections damage the feeding mechanism of the sandfly vector and implement parasite transmission by bite","volume":"89","author":"Y Schlein","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pone.0325178.ref029","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4269\/ajtmh.1994.50.1.TM0500010020","article-title":"Mortality of Leishmania major in Phlebotomus papatasi caused by plant feeding of the sand flies","volume":"50","author":"Y Schlein","year":"1994","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0325178.ref030","doi-asserted-by":"crossref","first-page":"107238","DOI":"10.1016\/j.actatropica.2024.107238","article-title":"Attractiveness of Golden Hamster infected with Leishmania amazonensis (Kinetoplastida: Trypanosomatidae) to laboratory-reared Lutzomyia longipalpis (Diptera: Psychodidae)","volume":"255","author":"FB da Rocha Silva","year":"2024","journal-title":"Acta Trop"},{"key":"pone.0325178.ref031","doi-asserted-by":"crossref","DOI":"10.1590\/s1678-9946202264032","article-title":"Predominance of Leishmania (Leishmania) amazonensis DNA in Lutzomyia longipalpis sand flies (Diptera: Psychodidae) from an endemic area for leishmaniasis in Northeastern Brazil","volume":"64","author":"R Carvalho-Silva","year":"2022","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"8","key":"pone.0325178.ref032","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2011.03.021","article-title":"Recent advances in leishmaniasis treatment","volume":"15","author":"TS Tiuman","year":"2011","journal-title":"Int J Infect Dis"},{"issue":"1","key":"pone.0325178.ref033","first-page":"26","article-title":"Limitations of Current Therapeutic Options, Possible Drug Targets and Scope of Natural Products in Control of Leishmaniasis","volume":"18","author":"N Tiwari","year":"2018","journal-title":"Mini Rev Med Chem"},{"key":"pone.0325178.ref034","doi-asserted-by":"crossref","first-page":"579891","DOI":"10.3389\/fchem.2020.579891","article-title":"Use of Natural Products in Leishmaniasis Chemotherapy: An Overview","volume":"8","author":"LFO Gervazoni","year":"2020","journal-title":"Front Chem"},{"issue":"12","key":"pone.0325178.ref035","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.phymed.2011.03.004","article-title":"Plant derived therapeutics for the treatment of Leishmaniasis","volume":"18","author":"R Sen","year":"2011","journal-title":"Phytomedicine"},{"issue":"5","key":"pone.0325178.ref036","first-page":"967","article-title":"Leishmaniasis treatment: update of possibilities for drug repurposing","volume":"23","author":"VV Andrade-Neto","year":"2018","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"22","key":"pone.0325178.ref037","doi-asserted-by":"crossref","first-page":"6885","DOI":"10.1016\/j.bmc.2011.09.025","article-title":"Pterocarpanquinones, aza-pterocarpanquinone and derivatives: synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis","volume":"19","author":"CD Buarque","year":"2011","journal-title":"Bioorg Med Chem"},{"issue":"10","key":"pone.0325178.ref038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109672","article-title":"Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (Viannia) braziliensis and controls lesions in infected hamsters","volume":"9","author":"L Costa","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"pone.0325178.ref039","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1128\/AAC.01787-15","article-title":"Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis","volume":"60","author":"EF Cunha-J\u00fanior","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"pone.0325178.ref040","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/jac\/dkr158","article-title":"Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis","volume":"66","author":"EF da Cunha-J\u00fanior","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"pone.0325178.ref041","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40409-018-0174-7","article-title":"Second-generation pterocarpanquinones: synthesis and antileishmanial activity","volume":"24","author":"VDS Fai\u00f5es","year":"2018","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"issue":"4","key":"pone.0325178.ref042","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/jac\/dks498","article-title":"LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis","volume":"68","author":"GA Ribeiro","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"pone.0325178.ref043","article-title":"Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities","author":"S Gomes","year":"2016","journal-title":"J Braz Chem Soc"},{"issue":"23","key":"pone.0325178.ref044","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1055\/s-0036-1589095","article-title":"Synthesis of Stilbene-Quinone Hybrids through Heck Reactions in PEG-400","volume":"49","author":"F Demidoff","year":"2017","journal-title":"Synthesis"},{"issue":"3","key":"pone.0325178.ref045","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.ejmech.2008.04.009","article-title":"Synthesis and antimalarial activity of hydroxyethylpiperazine derivatives","volume":"44","author":"W Cunico","year":"2009","journal-title":"Eur J Med Chem"},{"issue":"3","key":"pone.0325178.ref046","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ijpddr.2014.10.005","article-title":"Oral effectiveness of PMIC4, a novel hydroxyethylpiperazine analogue, in Leishmania amazonensis","volume":"4","author":"MF de Vasconcelos","year":"2014","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"7","key":"pone.0325178.ref047","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1002\/ps.6900","article-title":"Effects of anti-Leishmania compounds in the behavior of the sand fly vector Lutzomyia longipalpis","volume":"78","author":"TN Ferreira","year":"2022","journal-title":"Pest Manag Sci"},{"key":"pone.0325178.ref048","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13071-016-1401-0","article-title":"Everybody loves sugar: first report of plant feeding in triatomines","volume":"9","author":"HM D\u00edaz-Albiter","year":"2016","journal-title":"Parasit Vectors"},{"issue":"1","key":"pone.0325178.ref049","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"PK Smith","year":"1985","journal-title":"Anal Biochem"},{"key":"pone.0325178.ref050","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760180482","article-title":"Development of Leishmania mexicana in Lutzomyia longipalpis in the absence of sugar feeding","volume":"114","author":"SG da Costa","year":"2019","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"11","key":"pone.0325178.ref051","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1002\/etc.3860","article-title":"Pyrethroid concentrations and persistence following indoor application","volume":"36","author":"LE Nakagawa","year":"2017","journal-title":"Environ Toxicol Chem"},{"issue":"17","key":"pone.0325178.ref052","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.3390\/molecules25173978","article-title":"Residual Larvicidal Activity of Quinones against Aedes aegypti","volume":"25","author":"RL Silva","year":"2020","journal-title":"Molecules"},{"issue":"3","key":"pone.0325178.ref053","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00436-008-1242-7","article-title":"Larvicidal activity of naturally occurring naphthoquinones and derivatives against the West Nile virus vector Culex pipiens","volume":"104","author":"A Michaelakis","year":"2009","journal-title":"Parasitol Res"},{"issue":"1","key":"pone.0325178.ref054","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1186\/s13071-017-2512-y","article-title":"Mosquito larvicidal activity of Cassia tora seed extract and its key anthraquinones aurantio-obtusin and obtusin","volume":"10","author":"VC Mbatchou","year":"2017","journal-title":"Parasit Vectors"},{"issue":"10","key":"pone.0325178.ref055","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.3390\/molecules15107090","article-title":"Bignoniaceae metabolites as semiochemicals","volume":"15","author":"L Castillo","year":"2010","journal-title":"Molecules"},{"issue":"11","key":"pone.0325178.ref056","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1021\/jf800331r","article-title":"Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus)","volume":"56","author":"K Mozaina","year":"2008","journal-title":"J Agric Food Chem"},{"issue":"1","key":"pone.0325178.ref057","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cropro.2011.09.009","article-title":"Antifeedant and toxic effects of naturally occurring and synthetic quinones to the cabbage looper, Trichoplusia ni","volume":"31","author":"Y Akhtar","year":"2012","journal-title":"Crop Protection"},{"issue":"14","key":"pone.0325178.ref058","doi-asserted-by":"crossref","first-page":"6090","DOI":"10.1021\/jf901760h","article-title":"Synthesis and insect antifeedant activity of plumbagin derivatives with the amino acid moiety","volume":"57","author":"T Sreelatha","year":"2009","journal-title":"J Agric Food Chem"},{"issue":"2","key":"pone.0325178.ref059","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S1742758400017094","article-title":"Effect of Plant Quinones on Insect Flight Muscle Mitochondria","volume":"16","author":"EN Magiri","year":"1995","journal-title":"Int J Trop Insect Sci"},{"issue":"13","key":"pone.0325178.ref060","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.phytochem.2011.01.040","article-title":"Tannins in plant-herbivore interactions","volume":"72","author":"RV Barbehenn","year":"2011","journal-title":"Phytochemistry"},{"issue":"4","key":"pone.0325178.ref061","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3390\/molecules26040825","article-title":"Plumbagin, a Potent Naphthoquinone from Nepenthes Plants with Growth Inhibiting and Larvicidal Activities","volume":"26","author":"A Rahman-Soad","year":"2021","journal-title":"Molecules"},{"issue":"8","key":"pone.0325178.ref062","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1271\/bbb.60017","article-title":"Insect antifeedants, pterocarpans and pterocarpol, in heartwood of Pterocarpus macrocarpus Kruz","volume":"70","author":"M Morimoto","year":"2006","journal-title":"Biosci Biotechnol Biochem"},{"issue":"3","key":"pone.0325178.ref063","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00726-005-0298-2","article-title":"When quinones meet amino acids: chemical, physical and biological consequences","volume":"30","author":"S Bittner","year":"2006","journal-title":"Amino Acids"},{"key":"pone.0325178.ref064","first-page":"151","article-title":"Chemistry of Cuticular Sclerotization","volume-title":"Advances in Insect Physiology","author":"M Sugumaran","year":"2010"},{"key":"pone.0325178.ref065","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/B978-012369493-5.50003-1","article-title":"Integumentary Systems.","volume-title":"Physiological Systems in Insects","author":"MJ. Klowden","year":"2008"},{"issue":"5","key":"pone.0325178.ref066","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1021\/jf902640u","article-title":"Design and synthesis of novel insecticides based on the serotonergic ligand 1-[(4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP)","volume":"58","author":"M Cai","year":"2010","journal-title":"J Agric Food Chem"},{"issue":"7","key":"pone.0325178.ref067","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.bmcl.2016.01.088","article-title":"Synthesis and bioactivities of novel piperazine-containing 1,5-Diphenyl-2-penten-1-one analogues from natural product lead","volume":"26","author":"G Xu","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"issue":"2","key":"pone.0325178.ref068","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cmdc.202000598","article-title":"Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides","volume":"16","author":"CD Aretz","year":"2021","journal-title":"ChemMedChem"},{"key":"pone.0325178.ref069","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511610493","volume-title":"The Biology of Blood-Sucking in Insects","author":"MJ Lehane","year":"2005"},{"issue":"1","key":"pone.0325178.ref070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12936-018-2171-2","article-title":"Attractive toxic sugar baits for controlling mosquitoes: a qualitative study in Bagamoyo, Tanzania","volume":"17","author":"MF Maia","year":"2018","journal-title":"Malar J"},{"issue":"4","key":"pone.0325178.ref071","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.mib.2008.06.003","article-title":"Leishmania sand fly interaction: progress and challenges","volume":"11","author":"PA Bates","year":"2008","journal-title":"Curr Opin Microbiol"},{"issue":"5","key":"pone.0325178.ref072","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41564-018-0154-2","article-title":"Revising Leishmania\u2019s life cycle","volume":"3","author":"PA Bates","year":"2018","journal-title":"Nat Microbiol"},{"issue":"9","key":"pone.0325178.ref073","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.pt.2006.06.012","article-title":"Phlebotomine sand flies and Leishmania parasites: friends or foes?","volume":"22","author":"S Kamhawi","year":"2006","journal-title":"Trends Parasitol"},{"key":"pone.0325178.ref074","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-3-319-75544-1_6","article-title":"Biology of the Leishmania\u2212Sand Fly Interaction.","volume-title":"Brazilian Sand Flies","author":"PFP Pimenta","year":"2018"},{"issue":"1","key":"pone.0325178.ref075","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1590\/S0301-80591997000100026","article-title":"Biology of Lutzomyia lenti (Mangabeira) (Diptera: Psychodidae)","volume":"26","author":"RP Brazil","year":"1997","journal-title":"An Soc Entomol Bras"},{"key":"pone.0325178.ref076","doi-asserted-by":"crossref","DOI":"10.3920\/978-90-8686-744-8","volume-title":"Ecology of parasite-vector interactions","author":"W Takken","year":"2013"},{"issue":"1","key":"pone.0325178.ref077","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1590\/S0103-50532009000100026","article-title":"Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives","volume":"20","author":"AJM da Silva","year":"2009","journal-title":"J Braz Chem Soc"},{"key":"pone.0325178.ref078","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijpddr.2019.10.004","article-title":"Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB","volume":"11","author":"Y P\u00e9rez-Pertejo","year":"2019","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"pone.0325178.ref079","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1515\/znc-2004-5-627","article-title":"Metabolic modifications of birch leaf phenolics by an herbivorous insect: detoxification of flavonoid aglycones via glycosylation","volume":"59","author":"J-P Salminen","year":"2004","journal-title":"Z Naturforsch C J Biosci"},{"key":"pone.0325178.ref080","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1021\/bk-2005-0906.ch006","article-title":"Assessment of natural products for control of Formosan subterranean termites.","volume-title":"Semiochemicals in pest and weed control","author":"WLA Osbrink","year":"2005"},{"issue":"6","key":"pone.0325178.ref081","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jinsphys.2006.02.007","article-title":"Potential role for gut microbiota in cell wall digestion and glucoside detoxification in Tenebrio molitor larvae","volume":"52","author":"FA Genta","year":"2006","journal-title":"J Insect Physiol"},{"issue":"9","key":"pone.0325178.ref082","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.pt.2020.06.006","article-title":"Sand Fly Studies Predict Transmission Potential of Drug-resistant Leishmania","volume":"36","author":"L Van Bockstal","year":"2020","journal-title":"Trends Parasitol"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0325178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T17:54:08Z","timestamp":1750874048000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0325178"}},"subtitle":[],"editor":[{"given":"Everton","family":"Falc\u00e3o de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":82,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0325178","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]}}}