{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:02:56Z","timestamp":1787022176635,"version":"build-2736575974"},"reference-count":89,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec030\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Musculoskeletal disorders are a major cause of disability worldwide, significantly impacting office workers due to prolonged sitting and lack of movement. Implementing therapeutic exercise interventions in the workplace has been identified as a feasible and cost-effective strategy to address spinal pain. However, understanding workers\u2019 perspectives and workplace barriers is essential for designing effective interventions. This study aims to develop and evaluate a web-based workplace intervention with active breaks to reduce spinal pain among office workers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec031\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study follows a sequential exploratory mixed-methods design. The qualitative phase will use semi-structured interviews with office workers to explore their experiences with spinal pain, active breaks, and perceived barriers to implementation. These findings will inform the development of a six-week web-based therapeutic exercise intervention, which will be evaluated through a two-arm cluster randomised controlled trial. The trial will compare an intervention group performing structured active breaks during work hours with a control group maintaining their usual routine. Primary outcomes include pain intensity (Visual Analogue Scale), spinal dysfunction (Spine Functional Index), and adherence to the program. Secondary outcomes include quality of life (EQ-5D-5L) and exercise motivation (Behavioural Regulation in Exercise Questionnaire-2). Statistical analyses will compare within- and between-group differences to assess the intervention\u2019s effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec032\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Web-based interventions can enhance adherence to active breaks and provide an accessible, cost-effective solution for spinal pain management in sedentary workplaces. By adopting a mixed-methods approach, this study will generate valuable insights into implementing workplace exercise interventions, taking into account workers\u2019 expectations, workplace context, and adherence factors. Findings may inform future interventions aimed at managing musculoskeletal disorders in office workers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec033\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT05571124<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0325376","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T13:36:02Z","timestamp":1749476162000},"page":"e0325376","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["A web-based workplace exercise intervention among office workers with spinal pain: Protocol of a mixed methods study"],"prefix":"10.1371","volume":"20","author":[{"given":"Carlos","family":"Tersa-Miralles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Bellon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5822-239X","authenticated-orcid":true,"given":"Maria","family":"Masbernat-Almenara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-3950","authenticated-orcid":true,"given":"Francesc","family":"Rub\u00ed-Carnacea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Rubinat","family":"Arnaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"issue":"10100","key":"pone.0325376.ref001","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"GBD 2016 Disease and Injury Incidence and Prevalence Collaborators","year":"2017","journal-title":"Lancet"},{"issue":"3","key":"pone.0325376.ref002","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.berh.2015.08.002","article-title":"Economic impact of musculoskeletal disorders (MSDs) on work in Europe","volume":"29","author":"S Bevan","year":"2015","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"pone.0325376.ref003","article-title":"Agencia Europea para la Seguridad y la Salud en el Trabajo. 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