{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T04:07:55Z","timestamp":1750910875888,"version":"3.41.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2002-KH125938, HI22C0733"],"award-info":[{"award-number":["RS-2002-KH125938, HI22C0733"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00253065"],"award-info":[{"award-number":["RS-2023-00253065"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>This retrospective study analyzed optical coherence tomography (OCT) findings in 130 eyes of 130 patients with retinitis pigmentosa (RP) at initial diagnosis, including 42 with cystoid macular edema (CME) and 88 without, between September 2016 and March 2024. The CME group exhibited increased central macular thickness (CMT) (257.50\u2009\u00b1\u2009104.98 \u00b5m vs. 171.40\u2009\u00b1\u200973.15 \u00b5m, p\u2009=\u20090.000), whereas the non-CME group had greater subfoveal choroidal thickness (SCT) (294.52\u2009\u00b1\u2009122.85 \u00b5m vs. 246.98\u2009\u00b1\u200987.31 \u00b5m, p\u2009=\u20090.043), total choroidal area (TCA) (4.64\u2009\u00b1\u20091.98 mm\u00b2 vs. 3.82\u2009\u00b1\u20091.34 mm\u00b2, p\u2009=\u20090.031), stromal area (SA) (1.85\u2009\u00b1\u20090.76 mm\u00b2 vs. 1.53\u2009\u00b1\u20090.54 mm\u00b2, p\u2009=\u20090.025), luminal area (LA) (2.79\u2009\u00b1\u20091.22 mm\u00b2 vs. 2.30\u2009\u00b1\u20090.81 mm\u00b2, p\u2009=\u20090.033), and foveal avascular zone in the superficial capillary plexus (FAZ_SCP) (0.42\u2009\u00b1\u20090.31 mm\u00b2 vs. 0.27\u2009\u00b1\u20090.12 mm\u00b2, p\u2009=\u20090.022). The CME group had more moderate stage cases (47.62% vs. 26.14%, p\u2009=\u20090.015), while the non-CME group had more advanced cases (39.77% vs. 9.52%, p\u2009=\u20090.000). Visual acuity (logMAR) worsened in advanced stages for both groups (CME: 1.62\u2009\u00b1\u20090.79, p\u2009=\u20090.003; Non-CME: 1.12\u2009\u00b1\u20090.80, p\u2009=\u20090.000). In the CME group, FAZ in the deep capillary plexus (FAZ_DCP) enlarged from moderate to advanced stages (0.28\u2009\u00b1\u20090.12 mm\u00b2 to 0.64\u2009\u00b1\u20090.09 mm\u00b2, p\u2009=\u20090.025), and vessel density in the deep capillary plexus (VD_DCP) decreased from early to moderate stages (31.83\u2009\u00b1\u20093.94% to 28.75\u2009\u00b1\u20092.71%, p\u2009=\u20090.036), whereas superficial capillary plexus vessel density (VD_SCP) remained stable across stages (early: 32.82\u2009\u00b1\u20092.59%, moderate: 31.04\u2009\u00b1\u20092.37%, advanced: 31.52\u2009\u00b1\u20091.26%, all p\u2009&gt;\u20090.1). The non-CME group exhibited progressive declines in CMT (early: 226.27\u2009\u00b1\u200938.60 \u00b5m, moderate: 195.04\u2009\u00b1\u200952.56 \u00b5m, advanced: 108.83\u2009\u00b1\u200959.72 \u00b5m, all p\u2009&lt;\u20090.01) and choroidal vascularity index (CVI) (early: 0.61\u2009\u00b1\u20090.02, moderate: 0.60\u2009\u00b1\u20090.02, advanced: 0.58\u2009\u00b1\u20090.04, all p\u2009&lt;\u20090.05). In the CME group, visual acuity (logMAR) was positively correlated with cyst area (p\u2009=\u20090.019, rho\u2009=\u20090.361) and FAZ_DCP (p\u2009=\u20090.002, rho\u2009=\u20090.564). These findings suggest that RP-CME may be associated with choroidal atrophy regardless of disease stage and could have a compensatory mechanism to SCP. Cyst area and FAZ_DCP may serve as indicators of visual acuity in RP-CME.<\/jats:p>","DOI":"10.1371\/journal.pone.0325654","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T17:27:21Z","timestamp":1750872441000},"page":"e0325654","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optical coherence tomography analysis at initial diagnosis in patients with retinitis pigmentosa and associated cystoid macular edema"],"prefix":"10.1371","volume":"20","author":[{"given":"Suk Hoon","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Un","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Een","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young 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