{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:02:56Z","timestamp":1787022176871,"version":"build-2736575974"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Background<\/jats:title>\n Tuberculosis (TB) substantially compromises health-related quality of life (HRQoL), yet limited studies have assessed its impact on Ethiopian patients using the EQ-5D instrument. This study evaluates HRQoL, estimates health state utility values, and identifies associated factors among TB patients in Ethiopia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A cross-sectional study was conducted across 20 public health centers in Addis Ababa, Ethiopia, involving 672 TB patients selected via proportional allocation. HRQoL was measured using the EuroQol five-dimension five-level (EQ-5D-5L) tool. Predictors of utility scores were analyzed using the Kruskal-Wallis test and Tobit censored regression models.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Anxiety\/depression was the most frequently affected dimension (55.4% of participants). The mean EQ-5D-5L utility score was 0.91 (SD\u2009\u00b1\u20090.14), and the mean EQ-VAS score was 80.6 (SD\u2009\u00b1\u200915.6). Older age (55\u201364 years: \u03b2\u2009= \u22120.067,\n p<\/jats:italic>\n \u2009<\u20090.001;\u2009\u2265\u200965 years: \u03b2\u2009= \u22120.383,\n p<\/jats:italic>\n \u2009<\u20090.001) and unemployment (\u03b2\u2009= \u22120.119,\n p<\/jats:italic>\n \u2009<\u20090.001) were associated with significantly lower HRQoL. Conversely, higher income (\u03b2\u2009=\u20090.056,\n p<\/jats:italic>\n \u2009<\u20090.001), absence of comorbidities (\u03b2\u2009=\u20090.059,\n p<\/jats:italic>\n \u2009<\u20090.001), and mid-treatment duration (4\u20135 months: \u03b2\u2009=\u20090.029,\n p<\/jats:italic>\n \u2009=\u20090.011) correlated with better HRQoL.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The findings underscore the influence of socio-demographic and clinical factors on HRQoL among TB patients in Ethiopia, calling for targeted interventions and policy reforms to enhance treatment outcomes and patient support.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0326033","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:42:22Z","timestamp":1750772542000},"page":"e0326033","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study"],"prefix":"10.1371","volume":"20","author":[{"given":"Tenaw Baye","family":"Tarekegn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getachew","family":"Alemkere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3581-6451","authenticated-orcid":true,"given":"Eskinder Eshetu","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"pone.0326033.ref001","volume-title":"Global tuberculosis report 2023","author":"Organization WH","year":"2023"},{"key":"pone.0326033.ref002","volume-title":"Global tuberculos\u0131s report 2022","author":"Organization WH","year":"2022"},{"issue":"4","key":"pone.0326033.ref003","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3390\/idr14040055","article-title":"Health-Related Quality of Life (HRQoL) of Patients with Tuberculosis: A Review","volume":"14","author":"S Yasobant","year":"2022","journal-title":"Infect Dis Rep"},{"issue":"4","key":"pone.0326033.ref004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174605","article-title":"Health-related quality of life in South African patients with pulmonary tuberculosis","volume":"12","author":"T Kastien-Hilka","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"pone.0326033.ref005","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1186\/s13104-018-3904-6","article-title":"The impact of social support on the health-related quality of life of adult patients with tuberculosis in Harare, Zimbabwe: a cross-sectional survey","volume":"11","author":"C Zarova","year":"2018","journal-title":"BMC Res Notes"},{"issue":"1","key":"pone.0326033.ref006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029775","article-title":"Health related quality of life among patients with tuberculosis and HIV in Thailand","volume":"7","author":"W Kittikraisak","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"pone.0326033.ref007","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s11136-012-0329-x","article-title":"A systematic review and meta-analysis of the impact of tuberculosis on health-related quality of life","volume":"22","author":"M Bauer","year":"2013","journal-title":"Qual Life Res"},{"key":"pone.0326033.ref008","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijid.2014.12.045","article-title":"Health status and quality of life in tuberculosis","volume":"32","author":"J Brown","year":"2015","journal-title":"Int J Infect Dis"},{"issue":"2","key":"pone.0326033.ref009","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0167-6296(01)00130-8","article-title":"The estimation of a preference-based measure of health from the SF-36","volume":"21","author":"J Brazier","year":"2002","journal-title":"J Health Econ"},{"key":"pone.0326033.ref010","volume-title":"A life that\u2019s worth living\u2013measuring health-related quality of life among people treated for tuberculosis in Viet Nam: a longitudinal EQ-5D-5L survey","author":"LNQ Vo","year":"2024"},{"issue":"8","key":"pone.0326033.ref011","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s10198-020-01195-8","article-title":"Which multi-attribute utility instruments are recommended for use in cost-utility analysis? 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