{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T15:27:14Z","timestamp":1784388434712,"version":"3.55.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Allergic rhinitis (AR) is a prevalent chronic disease among children, influenced by environmental and genetic factors. Understanding regional aeroallergen sensitization patterns is essential for targeted intervention. This study investigates the prevalence of AR and its associated aeroallergen sensitization among schoolchildren in Jeju, Korea. A cross-sectional, population-based study was conducted in 2016 on 1,067 schoolchildren aged 9\u201316 years. Data were collected using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and skin prick tests for 18 common aeroallergens. Statistical analysis was performed using multiple logistic regression to determine risk factors for AR. The prevalence of AR was 29.0%, with the highest sensitization rates observed for Dermatophagoides pteronyssinus (76.5%), Dermatophagoides farinae (60.9%), and Japanese cedar pollen (39.1%). Sensitization to multiple aeroallergens (polysensitivity) was significantly associated with increased AR risk (OR 1.58, 95% CI: 1.017\u20132.455, p\u2009=\u20090.042). Age-related variations in sensitization patterns were noted, with younger children showing higher overall sensitization rates. This study provides evidence of region-specific allergen sensitization patterns in pediatric AR. The high prevalence of Japanese cedar pollen sensitization highlights the need for further investigation into environmental exposure and potential preventive measures.<\/jats:p>","DOI":"10.1371\/journal.pone.0326070","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T17:43:01Z","timestamp":1749836581000},"page":"e0326070","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and aeroallergen sensitization in pediatric Allergic Rhinitis: A population-based study in Jeju, Korea"],"prefix":"10.1371","volume":"20","author":[{"given":"Min-su","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5902-722X","authenticated-orcid":true,"given":"Jung-Kook","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Chul","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"issue":"1","key":"pone.0326070.ref001","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5414\/ALX02120E","article-title":"ARIA guideline 2019: treatment of allergic rhinitis in the German health system","volume":"3","author":"L Klimek","year":"2019","journal-title":"Allergol Select"},{"issue":"9537","key":"pone.0326070.ref002","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys","volume":"368","author":"MI Asher","year":"2006","journal-title":"Lancet"},{"issue":"1","key":"pone.0326070.ref003","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1398-9995.2008.01884.x","article-title":"Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three","volume":"64","author":"N A\u00eft-Khaled","year":"2009","journal-title":"Allergy"},{"issue":"3","key":"pone.0326070.ref004","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.12130","article-title":"Worldwide prevalence of rhinitis in adults: A review of definitions and temporal evolution","volume":"12","author":"M Savour\u00e9","year":"2022","journal-title":"Clin Transl Allergy"},{"issue":"2","key":"pone.0326070.ref005","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1398-9995.2009.02244.x","article-title":"Is the prevalence of asthma declining? 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Salo","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"pone.0326070.ref012","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jaci.2005.05.017","article-title":"Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey","volume":"116","author":"SJ Jr Arbes","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"pone.0326070.ref013","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4168\/aard.2023.11.1.3","article-title":"Associations between pollen and allergic rhinitis in children and adolescents","volume":"11","author":"KS Lee","year":"2023","journal-title":"Allergy Asthma Respir Dis"},{"issue":"4","key":"pone.0326070.ref014","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2500\/ajra.2016.30.4311","article-title":"Increased expression of the aryl hydrocarbon receptor in allergic nasal mucosa, 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J Investig Allergol Clin Immunol","volume":"8","author":"L Caraballo","year":"1998"},{"issue":"6","key":"pone.0326070.ref033","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/all.12164","article-title":"Cedar and cypress pollen counts are associated with the prevalence of allergic diseases in Japanese schoolchildren","volume":"68","author":"K Yoshida","year":"2013","journal-title":"Allergy"},{"issue":"2","key":"pone.0326070.ref034","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2332\/allergolint.O-07-513","article-title":"A 13-year study of Japanese cedar pollinosis in Japanese schoolchildren","volume":"57","author":"K Ozasa","year":"2008","journal-title":"Allergol Int"},{"issue":"7","key":"pone.0326070.ref035","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1111\/all.14749","article-title":"Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA","volume":"76","author":"V Muddaluru","year":"2021","journal-title":"Allergy"},{"issue":"10","key":"pone.0326070.ref036","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/j.1398-9995.2009.02089.x","article-title":"GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe","volume":"64","author":"GJ Burbach","year":"2009","journal-title":"Allergy"},{"issue":"10","key":"pone.0326070.ref037","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1001\/jama.2024.0530","article-title":"Allergic Rhinitis: A Review","volume":"331","author":"JA Bernstein","year":"2024","journal-title":"JAMA"},{"issue":"5","key":"pone.0326070.ref038","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jaci.2010.12.1106","article-title":"Allergy-related outcomes in relation to serum IgE: results from the National Health and Nutrition Examination Survey 2005-2006","volume":"127","author":"PM Salo","year":"2011","journal-title":"J Allergy Clin 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