{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:02:02Z","timestamp":1776312122988,"version":"3.50.1"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014589","name":"Chief Scientist Office, Scottish Government Health and Social Care Directorate","doi-asserted-by":"publisher","award":["HIPS\/19\/27"],"award-info":[{"award-number":["HIPS\/19\/27"]}],"id":[{"id":"10.13039\/100014589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007560","name":"Chiesi Pharmaceuticals","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014589","name":"Chief Scientist Office, Scottish Government Health and Social Care Directorate","doi-asserted-by":"publisher","award":["HIPS\/19\/27"],"award-info":[{"award-number":["HIPS\/19\/27"]}],"id":[{"id":"10.13039\/100014589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014589","name":"Chief Scientist Office, Scottish Government Health and Social Care Directorate","doi-asserted-by":"publisher","award":["HIPS\/19\/27"],"award-info":[{"award-number":["HIPS\/19\/27"]}],"id":[{"id":"10.13039\/100014589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014589","name":"Chief Scientist Office, Scottish Government Health and Social Care Directorate","doi-asserted-by":"publisher","award":["HIPS\/19\/27"],"award-info":[{"award-number":["HIPS\/19\/27"]}],"id":[{"id":"10.13039\/100014589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Chronic Obstructive Pulmonary Disease (COPD) is a growing global challenge. We undertook a process evaluation embedded within the Tailored Intervention at home for patients with moderate-to-severe COPD and Co-Morbidities by Pharmacists and Consultant Physicians (TICC PCP) pilot randomised controlled trial (RCT), which explored patient\/stakeholder perceptions of the intervention, acceptability of trial procedures, and barriers\/facilitators to intervention implementation. Semi-structured telephone interviews were conducted with intervention patients (20) and stakeholders (10); data were analysed thematically, conceptualised through Normalisation Process Theory. Patient perspectives compared based on socio-economic status (SES). Patients\/stakeholders reported positive perceptions of the intervention\/trial procedures. Pharmacists provided support across a range of health\/social issues. Challenges related to: recruitment; workload\/lone-working; managing patient complexity; and data collection. There were suggestions Pharmacists were able to undertake more actions to support patients from low SES areas. Overall, intervention and trial procedures were acceptable to patients and stakeholders. Findings support progression to full-scale RCT.<\/jats:p>","DOI":"10.1371\/journal.pone.0326178","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T17:48:37Z","timestamp":1751305717000},"page":"e0326178","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Process evaluation of a pragmatic, multicentre pilot Randomised Controlled Trial (RCT) in primary care: Tailored intervention for COPD and Co-morbidities by Pharmacists and Consultant Physicians (TICC PCP)"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-0384","authenticated-orcid":true,"given":"Karen","family":"Wood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Lowrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Moir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Attwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-2338","authenticated-orcid":true,"given":"Andrew","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Rankine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9780-1135","authenticated-orcid":true,"given":"Frances S.","family":"Mair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"issue":"6","key":"pone.0326178.ref001","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S2213-2600(20)30105-3","article-title":"Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"8","author":"Collaborators GBD Chronic Respiratory Disease","year":"2020","journal-title":"Lancet Respir Med"},{"key":"pone.0326178.ref002","volume-title":"COPD Best Practice Guide The Scottish Government","author":"The Scottish Government","year":"2017"},{"issue":"10258","key":"pone.0326178.ref003","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"T Vos","year":"2020","journal-title":"Lancet"},{"key":"pone.0326178.ref004","article-title":"S32\u2005Epidemiology of chronic obstructive pulmonary disease (COPD) in the uk: findings from the british lung foundation\u2019s \u2018respiratory health of the nation\u2019 project","volume":"71","author":"N Snell","year":"2016","journal-title":"Thorax"},{"issue":"3","key":"pone.0326178.ref005","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3109\/15412555.2011.648030","article-title":"Chronic obstructive pulmonary disease and socioeconomic status: a systematic review","volume":"9","author":"AS Gershon","year":"2012","journal-title":"COPD"},{"key":"pone.0326178.ref006","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1108\/HE-06-2020-0044","article-title":"Prevalence of COPD by age, sex, socioeconomic position and smoking status; 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