{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:14:22Z","timestamp":1751516062415,"version":"3.41.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>We investigated the potential molecular mechanisms of <jats:italic>Synechococcus<\/jats:italic> sp. XM-24 affect gastric cancer (GC) development. Furthermore, this study aimed to provide a theoretical basis for developing novel therapeutic drugs for treating GC.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The interactions between <jats:italic>Synechococcus<\/jats:italic> sp. XM-24 and targeted proteins in GC were analyzed through network pharmacology and molecular docking. Molecular dynamics (MD) simulation of the protein\u2013small molecule complex obtained from molecular docking were performed using the Gromacs v2022.03 software. Based on the intersecting target genes of <jats:italic>Synechococcus<\/jats:italic> sp. XM-24 and GC, Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes analyses were performed to obtain the associated biological processes (BP), cellular components (CC), molecular functions (MF), and signal transduction pathways.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In total, 609 intersecting targets were identified between <jats:italic>Synechococcus<\/jats:italic> sp. XM-24 and GC, with nine key target genes (<jats:italic>AKT1<\/jats:italic>, <jats:italic>ALB<\/jats:italic>, <jats:italic>IL1B<\/jats:italic>, <jats:italic>SRC<\/jats:italic>, <jats:italic>STAT3<\/jats:italic>, <jats:italic>EGFR<\/jats:italic>, <jats:italic>HSP90AA1<\/jats:italic>, <jats:italic>ESR1<\/jats:italic>, and <jats:italic>BCL2<\/jats:italic>) being identified as active components of <jats:italic>Synechococcus<\/jats:italic> sp. XM-24. These key target genes were involved in 1,028 BP, 110 CC, 312 MF, and 200 signaling pathways. The enriched signaling pathways mainly included the cancer pathway, metabolic pathway, phosphatidylinositol 3-kinase\u2013protein kinase B(PI3K-AKT) signaling pathway, and Rat sarcoma signaling pathway. Additionally, molecular docking analysis revealed strong binding activities between 10 active components of <jats:italic>Synechococcus<\/jats:italic> sp. XM-24, including methyl vaccenate, allyl methallyl ether, and 11-octadecenoic acid, with key target proteins such as albumin (ALB). MD simulations demonstrated a stable binding of ALB and methyl vaccenate, with a binding free energy of \u221248.39 kcal\/mol.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Overall, the findings of this study reveal the therapeutic potential of <jats:italic>Synechococcus<\/jats:italic> sp. XM-24 in the prevention and treatment of GC, along with providing a theoretical basis for further development in GC treatment employing <jats:italic>Synechococcus<\/jats:italic> sp. XM-24.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0326664","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:32:59Z","timestamp":1751477579000},"page":"e0326664","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the mechanism of Synechococcus sp. 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