{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:06:33Z","timestamp":1779386793454,"version":"3.53.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hebei Province Medical Science Research Project Plan","award":["20242394"],"award-info":[{"award-number":["20242394"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>To establish a scientifically grounded and feasible intravenous infusion management protocol for patients with Aggressive behavior due to mental disorders. Methods: Guided by Donabedian\u2019s theory, an initial draft of the management protocol was developed through a comprehensive literature review and semi-structured interviews with clinical experts. From June to July 2024, two rounds of expert consultation were conducted, and revisions were made until the final protocol was established. Results: The response rate for both rounds of expert questionnaires was 100%, with authority coefficients of 0.915 and 0.92. After the second round, the coefficients of variation for item importance ranged from 0 to 0.115 and from 0 to 0.107, while Kendall\u2019s W coefficients were 0.506 and 0.628, respectively, indicating statistically significant expert consensus (P\u2009&lt;\u20090.05). Ultimately, the final protocol comprised 3 first-level items, 17 second-level items, and 41 third-level items. Conclusion: The intravenous infusion management protocol developed on the basis of Donabedian\u2019s theory is both rigorous and targeted, providing a foundation for the comprehensive management of intravenous infusion in patients with aggressive behavior.<\/jats:p>","DOI":"10.1371\/journal.pone.0326717","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:22:57Z","timestamp":1779384177000},"page":"e0326717","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a protocol for intravenous infusion management in patients with aggressive behavior due to mental disorders: A Donabedian framework 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