{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:44:15Z","timestamp":1792802655576,"version":"4.5.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chang Gung Memorial Hospital, Keelung, Taiwan","award":["CMRPG 2I0131"],"award-info":[{"award-number":["CMRPG 2I0131"]}],"id":[{"id":"https:\/\/ror.org\/02dnn6q67","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to investigate whether early axial length (AL) changes in the short term after 0.125% atropine treatment could predict long-term axial elongation in children with myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cohort study involving children aged 5\u201315 years with myopia who were treated with 0.125% atropine for myopia control. AL was measured 1\u20132 months after starting treatment and then every 3 months for follow-up visits. Regression analysis was used to develop a model of AL changes with time. A generalized estimating equation (GEE) model was then used to identify correlations between the early AL changes and long-term AL changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty eyes of 40 patients (mean age 8.4 years) were included in the final analysis. The estimation curve of AL changes with time indicated that the AL decreased at 67 days (the turning point in the regression model) after 0.125% atropine treatment and then increased gradually with time. Univariate GEE showed that a larger AL elongation in the initial 4 months was significantly associated with AL changes at 6 months (\u03b2\u2009=\u20090.354,\n                      <jats:italic>\n                        <jats:italic>P<\/jats:italic>\n                      <\/jats:italic>\n                      \u2009=\u20090.020, 6\u2009~\u200912 months period from baseline) and 12 months (\u03b2\u2009=\u20090.560,\n                      <jats:italic>\n                        <jats:italic>P<\/jats:italic>\n                      <\/jats:italic>\n                      \u2009=\u20090.045, 6\u2009~\u200918 months period from baseline) after that period in all myopic eyes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The magnitude of AL elongation in the initial 4 months of 0.125% atropine treatment correlated positively with the further half-year and one-year AL changes. Identifying these changes may be useful for controlling refractory myopia in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0327354","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T17:33:36Z","timestamp":1754588016000},"page":"e0327354","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early identification of the efficacy of 0.125% atropine treatment for children with Myopia: A prospective pilot 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