{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:30:58Z","timestamp":1773275458912,"version":"3.50.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Diabetes can cause serious complications such as liver damage and nerve pain. Unfortunately, existing treatment options for these problems often have limited effectiveness and unwanted side effects. To find better therapeutic alternatives with good efficacy and safety profile this study tested a novel quinazolinone derivative,\n                    <jats:italic>(E)-1-benzoyl-3-((4(dimethylamino)benzylidene)amino)-2-(4-(dimethylamino)phenyl)-2,3 dihydroquinazoline-4(1H)-one<\/jats:italic>\n                    , in diabetic mice\u2019s experiencing liver damage and neuropathic pain. Diabetes was induced in mice using alloxan (150\u2009mg\/kg). For possible antidiabetic effect, test compound was given in doses of 10\u2009mg\/kg and 20\u2009mg\/kg. The standard drugs used for comparison was Glibenclamide (5\u2009mg\/kg), Tramadol (50\u2009mg\/kg) and Diclofenac sodium (50\u2009mg\/kg) for pain relief, and Gabapentin (75\u2009mg\/kg) for nerve pain. Pain relieving effect was assessed using various test models (e.g., hot plate, writhing, allodynia, and hyperalgesia). Liver function was studied through blood tests and tissue examination. The test compound (at test dose of 20\u2009mg\/kg) led to a significant reduction in blood glucose even greater than the reduction seen with glibenclamide (5\u2009mg\/kg). Similarly, the test compound significantly reduced pain and showed protective effects on the liver. This new quinazolinone compound was found to be safe and effective in reducing diabetic nerve pain and liver damage in mice. It may offer a better alternative to currently available treatments like gabapentin and glibenclamide.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0327627","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:29:36Z","timestamp":1770229776000},"page":"e0327627","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of antidiabetic, hepatoprotective, and analgesic effects of quinazolinone derivative, (E)-1-Benzoyl-3-((4- (Dimethylamino) Benzylidene) Amino)-2-(4-(Dimethylamino) Phenyl)-2,3 dihydroquinazoline-4(1h)-one, in diabetes induced mice model"],"prefix":"10.1371","volume":"21","author":[{"given":"Haider","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Jan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gowhar","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Shaukat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdur","family":"Rahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2356-0751","authenticated-orcid":true,"given":"Ursula","family":"Abu Nahla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"12","key":"pone.0327627.ref001","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s40264-015-0339-z","article-title":"Drug-Induced Hyperglycaemia and Diabetes","volume":"38","author":"N Fathallah","year":"2015","journal-title":"Drug Saf"},{"issue":"6","key":"pone.0327627.ref002","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/brain\/awab079","article-title":"Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management","volume":"144","author":"TS Jensen","year":"2021","journal-title":"Brain"},{"issue":"6","key":"pone.0327627.ref003","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00002508-200211000-00002","article-title":"Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy","volume":"18","author":"KE Schmader","year":"2002","journal-title":"Clin J Pain"},{"issue":"2","key":"pone.0327627.ref004","doi-asserted-by":"crossref","DOI":"10.18295\/squmj.2016.16.02.002","article-title":"Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation","volume":"16","author":"J Mohamed","year":"2016","journal-title":"Sultan Qaboos Univ Med J"},{"key":"pone.0327627.ref005","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fitote.2017.05.001","article-title":"Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives","volume":"119","author":"D He","year":"2017","journal-title":"Fitoterapia"},{"key":"pone.0327627.ref006","doi-asserted-by":"crossref","unstructured":"A. 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