{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T22:09:18Z","timestamp":1764194958714,"version":"3.41.2"},"reference-count":108,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Toronto, Institute of Health Policy, Management, and Evaluation","award":["Not provided"],"award-info":[{"award-number":["Not provided"]}]},{"name":"Faculty of Medicine, University of Toronto","award":["Not provided"],"award-info":[{"award-number":["Not provided"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec026\">\n<jats:title>Background<\/jats:title>\n<jats:p>Current Utstein etiological classifications for out-of-hospital cardiac arrest (OHCA) are heterogenous and inaccurate when compared with robust sources. This heterogeneity may influence reporting incidence and outcomes and patient enrollment in observational studies and clinical trials. Circumstance-related factors may contribute to cardiac arrest; however, the role of these factors in improving the etiological classification of OHCA is unknown.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec027\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This scoping review was proposed to explore current evidence to identify the role of contributing factors, triggers, and prodromal symptoms of out-of-hospital cardiac arrest in the reported etiology of cardiac arrest based on emergency medical services data, medical records, or autopsy reports.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec028\">\n<jats:title>Method<\/jats:title>\n<jats:p>We searched Medline, Embase, and EMB review-Cochrane databases from 1946 to 2024. Studies were selected if the included population was adults with OHCA for whom the initial etiology was assigned, and any contributing factors, triggers, or prodromal symptoms of OHCA were reported. A descriptive review of the included studies was conducted.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec029\">\n<jats:title>Result<\/jats:title>\n<jats:p>The search yielded 24,833 citations. Seventy studies met the inclusion criteria. These studies were published predominantly in Europe and Asia between 2010 and 2024 and classified as contributing factors (n\u2009=\u200924), exercise (n\u2009=\u200913), environmental triggers (n\u2009=\u200924), and prodromal symptoms (n\u2009=\u20099). The etiology of cardiac arrest initially assigned to cardiac or obvious non-cardiac classification may be precipitated by seizures (n\u2009=\u20098), trauma (n\u2009=\u20097), alcohol or drug intoxication (n\u2009=\u20096), Covid-19 infection (n\u2009=\u20095), myocardial infarction (n\u2009=\u20094), suicide (n\u2009=\u20094), antipsychotic medications (n\u2009=\u20094), and illicit drug use (n\u2009=\u20093). Exercise and environmental factors (e.g., particulate matter (PM) 2.5\u00b5 and ambient temperature) may trigger cardiac arrest predominantly due to cardiac etiologies. Based on EMS data, approximately 50% of patients with OHCA experienced symptoms prior to cardiac arrest which suggested cardiac and non-cardiac etiologies.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec030\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Many circumstance-related factors may directly or indirectly contribute to cardiac arrest etiology classification. Listing these factors in the reporting template may help prehospital personnel and data abstractors gather enough information to identify more accurately the etiology of OHCA.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0327651","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T17:34:29Z","timestamp":1752687269000},"page":"e0327651","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of contributing factors, triggers, and prodromal symptoms in the etiological classification of out-of-hospital cardiac arrest; A\u00a0scoping review"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1210-0541","authenticated-orcid":true,"given":"Sedigheh","family":"Shaeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-2456","authenticated-orcid":true,"given":"Julie","family":"Considine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie N.","family":"Dainty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa Mariero","family":"Olasveengen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-9774","authenticated-orcid":true,"given":"Laurie J.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"pone.0327651.ref001","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.resuscitation.2019.12.042","article-title":"Survival after out-of-hospital cardiac arrest in Europe - results of the EuReCa TWO study","volume":"148","author":"J-T Gr\u00e4sner","year":"2020","journal-title":"Resuscitation"},{"key":"pone.0327651.ref002","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.resuscitation.2020.07.016","article-title":"Changes in the incidence of out-of-hospital cardiac arrest: differences between cardiac and non-cardiac aetiologies","volume":"155","author":"S Alqahtani","year":"2020","journal-title":"Resuscitation"},{"issue":"11","key":"pone.0327651.ref003","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.resuscitation.2010.08.006","article-title":"Global incidences of out-of-hospital cardiac arrest and survival rates: systematic review of 67 prospective studies","volume":"81","author":"J Berdowski","year":"2010","journal-title":"Resuscitation"},{"issue":"3","key":"pone.0327651.ref004","first-page":"233","article-title":"Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries. 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Dai","year":"2023","journal-title":"Environ Sci Pollut Res Int"},{"issue":"1","key":"pone.0327651.ref087","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2105\/AJPH.2021.306549","article-title":"Cold weather and cardiac arrest in 4 seasons: Helsinki, Finland, 1997-2018","volume":"112","author":"NRI Ryti","year":"2022","journal-title":"Am J Public Health"},{"issue":"7","key":"pone.0327651.ref088","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1136\/emj.2009.084269","article-title":"Prognostic significance of acute pain preceding out-of-hospital cardiac arrest","volume":"28","author":"J Inamasu","year":"2011","journal-title":"Emerg Med J"},{"key":"pone.0327651.ref089","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.resuscitation.2020.02.042","article-title":"Epidemiology and outcome of emergency medical service witnessed out-of-hospital-cardiac arrest by prodromal symptom: nationwide observational study","volume":"150","author":"SY 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